Phthalimide conjugation as a strategy for in vivo target protein degradation
Winter, Georg E., Buckley, Dennis L., Paulk, Joshiawa, Roberts, Justin M., Souza, Amanda, Dhe-Paganon, Sirano, Bradner, James E.
Published in Science (American Association for the Advancement of Science) (19.06.2015)
Published in Science (American Association for the Advancement of Science) (19.06.2015)
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YY1 Is a Structural Regulator of Enhancer-Promoter Loops
Weintraub, Abraham S., Li, Charles H., Zamudio, Alicia V., Sigova, Alla A., Hannett, Nancy M., Day, Daniel S., Abraham, Brian J., Cohen, Malkiel A., Nabet, Behnam, Buckley, Dennis L., Guo, Yang Eric, Hnisz, Denes, Jaenisch, Rudolf, Bradner, James E., Gray, Nathanael S., Young, Richard A.
Published in Cell (14.12.2017)
Published in Cell (14.12.2017)
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Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
Remillard, David, Buckley, Dennis L., Paulk, Joshiawa, Brien, Gerard L., Sonnett, Matthew, Seo, Hyuk‐Soo, Dastjerdi, Shiva, Wühr, Martin, Dhe‐Paganon, Sirano, Armstrong, Scott A., Bradner, James E.
Published in Angewandte Chemie (International ed.) (15.05.2017)
Published in Angewandte Chemie (International ed.) (15.05.2017)
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Mutant NPM1 Maintains the Leukemic State through HOX Expression
Brunetti, Lorenzo, Gundry, Michael C., Sorcini, Daniele, Guzman, Anna G., Huang, Yung-Hsin, Ramabadran, Raghav, Gionfriddo, Ilaria, Mezzasoma, Federica, Milano, Francesca, Nabet, Behnam, Buckley, Dennis L., Kornblau, Steven M., Lin, Charles Y., Sportoletti, Paolo, Martelli, Maria Paola, Falini, Brunangelo, Goodell, Margaret A.
Published in Cancer cell (10.09.2018)
Published in Cancer cell (10.09.2018)
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Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Nabet, Behnam, Ferguson, Fleur M., Seong, Bo Kyung A., Kuljanin, Miljan, Leggett, Alan L., Mohardt, Mikaela L., Robichaud, Amanda, Conway, Amy S., Buckley, Dennis L., Mancias, Joseph D., Bradner, James E., Stegmaier, Kimberly, Gray, Nathanael S.
Published in Nature communications (18.09.2020)
Published in Nature communications (18.09.2020)
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Journal Article
The dTAG system for immediate and target-specific protein degradation
Nabet, Behnam, Roberts, Justin M., Buckley, Dennis L., Paulk, Joshiawa, Dastjerdi, Shiva, Yang, Annan, Leggett, Alan L., Erb, Michael A., Lawlor, Matthew A., Souza, Amanda, Scott, Thomas G., Vittori, Sarah, Perry, Jennifer A., Qi, Jun, Winter, Georg E., Wong, Kwok-Kin, Gray, Nathanael S., Bradner, James E.
Published in Nature chemical biology (01.05.2018)
Published in Nature chemical biology (01.05.2018)
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Journal Article
A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Huang, Hai-Tsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L., Doctor, Zainab M., Buckley, Dennis L., Cho, Joong-Heui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D., Li, Ying, Treon, Steven P., Fischer, Eric S., Bradner, James E., Tan, Li, Gray, Nathanael S.
Published in Cell chemical biology (18.01.2018)
Published in Cell chemical biology (18.01.2018)
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Journal Article
BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
Winter, Georg E., Mayer, Andreas, Buckley, Dennis L., Erb, Michael A., Roderick, Justine E., Vittori, Sarah, Reyes, Jaime M., di Iulio, Julia, Souza, Amanda, Ott, Christopher J., Roberts, Justin M., Zeid, Rhamy, Scott, Thomas G., Paulk, Joshiawa, Lachance, Kate, Olson, Calla M., Dastjerdi, Shiva, Bauer, Sophie, Lin, Charles Y., Gray, Nathanael S., Kelliher, Michelle A., Churchman, L. Stirling, Bradner, James E.
Published in Molecular cell (06.07.2017)
Published in Molecular cell (06.07.2017)
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Journal Article
Plasticity in binding confers selectivity in ligand-induced protein degradation
Nowak, Radosław P., DeAngelo, Stephen L., Buckley, Dennis, He, Zhixiang, Donovan, Katherine A., An, Jian, Safaee, Nozhat, Jedrychowski, Mark P., Ponthier, Charles M., Ishoey, Mette, Zhang, Tinghu, Mancias, Joseph D., Gray, Nathanael S., Bradner, James E., Fischer, Eric S.
Published in Nature chemical biology (01.07.2018)
Published in Nature chemical biology (01.07.2018)
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Prostate cancer–associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4
Dai, Xiangpeng, Gan, Wenjian, Li, Xiaoning, Wang, Shangqian, Zhang, Wei, Huang, Ling, Liu, Shengwu, Zhong, Qing, Guo, Jianping, Zhang, Jinfang, Chen, Ting, Shimizu, Kouhei, Beca, Francisco, Blattner, Mirjam, Vasudevan, Divya, Buckley, Dennis L, Qi, Jun, Buser, Lorenz, Liu, Pengda, Inuzuka, Hiroyuki, Beck, Andrew H, Wang, Liewei, Wild, Peter J, Garraway, Levi A, Rubin, Mark A, Barbieri, Christopher E, Wong, Kwok-Kin, Muthuswamy, Senthil K, Huang, Jiaoti, Chen, Yu, Bradner, James E, Wei, Wenyi
Published in Nature medicine (01.09.2017)
Published in Nature medicine (01.09.2017)
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Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
Buckley, Dennis L, Van Molle, Inge, Gareiss, Peter C, Tae, Hyun Seop, Michel, Julien, Noblin, Devin J, Jorgensen, William L, Ciulli, Alessio, Crews, Craig M
Published in Journal of the American Chemical Society (14.03.2012)
Published in Journal of the American Chemical Society (14.03.2012)
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Catalytic in vivo protein knockdown by small-molecule PROTACs
Bondeson, Daniel P, Mares, Alina, Smith, Ian E D, Ko, Eunhwa, Campos, Sebastien, Miah, Afjal H, Mulholland, Katie E, Routly, Natasha, Buckley, Dennis L, Gustafson, Jeffrey L, Zinn, Nico, Grandi, Paola, Shimamura, Satoko, Bergamini, Giovanna, Faelth-Savitski, Maria, Bantscheff, Marcus, Cox, Carly, Gordon, Deborah A, Willard, Ryan R, Flanagan, John J, Casillas, Linda N, Votta, Bartholomew J, den Besten, Willem, Famm, Kristoffer, Kruidenier, Laurens, Carter, Paul S, Harling, John D, Churcher, Ian, Crews, Craig M
Published in Nature chemical biology (01.08.2015)
Published in Nature chemical biology (01.08.2015)
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Journal Article
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins
Buckley, Dennis L, Raina, Kanak, Darricarrere, Nicole, Hines, John, Gustafson, Jeffrey L, Smith, Ian E, Miah, Afjal H, Harling, John D, Crews, Craig M
Published in ACS chemical biology (21.08.2015)
Published in ACS chemical biology (21.08.2015)
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Journal Article
Small-Molecule-Mediated Degradation of the Androgen Receptor through Hydrophobic Tagging
Gustafson, Jeffrey L., Neklesa, Taavi K., Cox, Carly S., Roth, Anke G., Buckley, Dennis L., Tae, Hyun Seop, Sundberg, Thomas B., Stagg, D. Blake, Hines, John, McDonnell, Donald P., Norris, John D., Crews, Craig M.
Published in Angewandte Chemie International Edition (10.08.2015)
Published in Angewandte Chemie International Edition (10.08.2015)
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Transcription control by the ENL YEATS domain in acute leukaemia
Erb, Michael A., Scott, Thomas G., Li, Bin E., Xie, Huafeng, Paulk, Joshiawa, Seo, Hyuk-Soo, Souza, Amanda, Roberts, Justin M., Dastjerdi, Shiva, Buckley, Dennis L., Sanjana, Neville E., Shalem, Ophir, Nabet, Behnam, Zeid, Rhamy, Offei-Addo, Nana K., Dhe-Paganon, Sirano, Zhang, Feng, Orkin, Stuart H., Winter, Georg E., Bradner, James E.
Published in Nature (London) (09.03.2017)
Published in Nature (London) (09.03.2017)
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Journal Article
Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands
Gechijian, Lara N., Buckley, Dennis L., Lawlor, Matthew A., Reyes, Jaime M., Paulk, Joshiawa, Ott, Christopher J., Winter, Georg E., Erb, Michael A., Scott, Thomas G., Xu, Mousheng, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Kwiatkowski, Nicholas P., Perry, Jennifer A., Qi, Jun, Gray, Nathanael S., Bradner, James E.
Published in Nature chemical biology (01.04.2018)
Published in Nature chemical biology (01.04.2018)
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Journal Article
Targetable BET proteins- and E2F1-dependent transcriptional program maintains the malignancy of glioblastoma
Xu, Liang, Chen, Ye, Mayakonda, Anand, Koh, Lynnette, Chong, Yuk Kien, Buckley, Dennis L., Sandanaraj, Edwin, Lim, See Wee, Lin, Ruby Yu-Tong, Ke, Xin-Yu, Huang, Mo-Li, Chen, Jianxiang, Sun, Wendi, Wang, Ling-Zhi, Goh, Boon Cher, Dinh, Huy Q., Kappei, Dennis, Winter, Georg E., Ding, Ling-Wen, Ang, Beng Ti, Berman, Benjamin P., Bradner, James E., Tang, Carol, Koeffler, H. Phillip
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (29.05.2018)
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Journal Article
Small-Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
Buckley, Dennis L., Gustafson, Jeffrey L., Van Molle, Inge, Roth, Anke G., Tae, Hyun Seop, Gareiss, Peter C., Jorgensen, William L., Ciulli, Alessio, Crews, Craig M.
Published in Angewandte Chemie International Edition (12.11.2012)
Published in Angewandte Chemie International Edition (12.11.2012)
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Journal Article
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors
Liu, Shuai, Yosief, Hailemichael O, Dai, Lingling, Huang, He, Dhawan, Gagan, Zhang, Xiaofeng, Muthengi, Alex M, Roberts, Justin, Buckley, Dennis L, Perry, Jennifer A, Wu, Lei, Bradner, James E, Qi, Jun, Zhang, Wei
Published in Journal of medicinal chemistry (13.09.2018)
Published in Journal of medicinal chemistry (13.09.2018)
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