Preclinical Development of a Hematopoietic Stem and Progenitor Cell Bioengineered Factor VIII Lentiviral Vector Gene Therapy for Hemophilia A
Doering, Christopher B, Denning, Gabriela, Shields, Jordan E, Fine, Eli J, Parker, Ernest T, Srivastava, Alok, Lollar, Pete, Spencer, H Trent
Published in Human gene therapy (01.10.2018)
Published in Human gene therapy (01.10.2018)
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Non-genotoxic conditioning facilitates hematopoietic stem cell gene therapy for hemophilia A using bioengineered factor VIII
Russell, Athena L., Prince, Chengyu, Lundgren, Taran S., Knight, Kristopher A., Denning, Gabriela, Alexander, Jordan S., Zoine, Jaquelyn T., Spencer, H. Trent, Chandrakasan, Shanmuganathan, Doering, Christopher B.
Published in Molecular therapy. Methods & clinical development (11.06.2021)
Published in Molecular therapy. Methods & clinical development (11.06.2021)
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Directed Engineering of a High-expression Chimeric Transgene as a Strategy for Gene Therapy of Hemophilia A
Doering, Christopher B, Denning, Gabriela, Dooriss, Kerry, Gangadharan, Bagirath, Johnston, Jennifer M, Kerstann, Keith W, McCarty, David A, Spencer, H Trent
Published in Molecular therapy (01.07.2009)
Published in Molecular therapy (01.07.2009)
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Assessment of Transduction of CD34+ Human Hematopoietic Stem Cells from Patients with Severe Hemophilia-Α with Lentiviral Vector Carrying a High Expression FVIII Transgene (CD68-ET3-LV)
Singh, Gurbind, A M, Mohanashankar, Velayudhan, Shaji R, Denning, Gabriela, Singh, Abraham Sunder, Jeba, Anbu, Abraham, Aby, Doering, Christopher B, Spencer, H Trent, Srivastava, Alok
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Cloning of a Novel Phosphatidylinositol Kinase-related Kinase
Denning, Gabriela, Jamieson, Lee, Maquat, Lynne E., Thompson, E. Aubrey, Fields, Alan P.
Published in The Journal of biological chemistry (22.06.2001)
Published in The Journal of biological chemistry (22.06.2001)
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F5‐Atlanta: A novel mutation in F5 associated with enhanced East Texas splicing and FV‐short production
Zimowski, Karen L., Petrillo, Teodolinda, Ho, Michelle D., Wechsler, Julie, Shields, Jordan E., Denning, Gabriela, Jhita, Navdeep, Rivera, Angel A., Escobar, Miguel A., Kempton, Christine L., Camire, Rodney M., Doering, Christopher B.
Published in Journal of thrombosis and haemostasis (01.07.2021)
Published in Journal of thrombosis and haemostasis (01.07.2021)
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The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain
Smith, Ian W., d'Aquino, Anne E., Coyle, Christopher W., Fedanov, Andrew, Parker, Ernest T., Denning, Gabriela, Spencer, Harold Trent, Lollar, Pete, Doering, Christopher B., Spiegel, Paul Clint
Published in Journal of thrombosis and haemostasis (01.01.2020)
Published in Journal of thrombosis and haemostasis (01.01.2020)
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Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency
Tran, Reginald, Myers, David R., Denning, Gabriela, Shields, Jordan E., Lytle, Allison M., Alrowais, Hommood, Qiu, Yongzhi, Sakurai, Yumiko, Li, William C., Brand, Oliver, Le Doux, Joseph M., Spencer, H. Trent, Doering, Christopher B., Lam, Wilbur A.
Published in Molecular therapy (04.10.2017)
Published in Molecular therapy (04.10.2017)
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Journal Article
Preclinical Development and Validation of a Hematopoietic Stem Cell-Based Lentivector Treatment for Hemophilia a
Doering, Christopher B, Denning, Gabriela, Shields, Jordan E, Swaney, William, Reeves, Lilith, Malik, Punam, Spencer, H. Trent
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Factor V Atlanta: A Novel Mutation in the F5 Gene Reveals Potential New Cis-Acting Elements Involved in Regulating FV-Short and TFPI Levels
Zimowski, Karen L, Ho, Michelle D., Shields, Jordan E, Denning, Gabriela, Petrillo, Teodolinda, Jhita, Navdeep, Rivera, Angel A, Escobar, Miguel A, Kempton, Christine L, Doering, Christopher B, Camire, Rodney M
Published in Blood (08.12.2017)
Published in Blood (08.12.2017)
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Journal Article
Lentiviral Vector Platform for Production of Bioengineered Recombinant Coagulation Factor VIII
Spencer, H Trent, Denning, Gabriela, Gautney, Richard E, Dropulic, Boro, Roy, Andre J, Baranyi, Lajos, Gangadharan, Bagirath, Parker, Ernest T, Lollar, Pete, Doering, Christopher B
Published in Molecular therapy (01.02.2011)
Published in Molecular therapy (01.02.2011)
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Identification of coagulation factor IX variants with enhanced activity through ancestral sequence reconstruction
Knight, Kristopher A., Coyle, Christopher W., Radford, Caelan E., Parker, Ernest T., Fedanov, Andrew, Shields, Jordan M., Szlam, Fania, Purchel, Anatolii, Chen, Michelle, Denning, Gabriela, Sniecinski, Roman M., Lollar, Pete, Spencer, H. Trent, Gaucher, Eric A., Doering, Christopher B.
Published in Blood advances (14.09.2021)
Published in Blood advances (14.09.2021)
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Journal Article
Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A
Dooriss, Kerry L, Denning, Gabriela, Gangadharan, Bagirath, Javazon, Elisabeth H, McCarty, David A, Spencer, H Trent, Doering, Christopher B
Published in Human gene therapy (01.05.2009)
Published in Human gene therapy (01.05.2009)
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Humanized High-Expression Factor VIII Encoding Lentiviral Vectors Efficiently Drive High-Level FVIII Expression in Murine and Human Hematopoietic Cells
Doering, Christopher, Denning, Gabriela, Kerstann, Keith, Gangadharan, Bagirath, Keefe, Robert, Dropolic, Boro, Spencer, H. Trent
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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Journal Article
Development of a Novel Recombinant Factor VIII Product through Transgene Engineering and Lentiviral-Driven Expression
Kerstann, Keith W, Lollar, Pete, Spencer, H. Trent, Denning, Gabriela, Baranyi, Lajos, Keefe, Robert, Dropulic, Boro, Doering, Christopher B
Published in Blood (16.11.2008)
Published in Blood (16.11.2008)
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