The coronavirus proofreading exoribonuclease mediates extensive viral recombination
Gribble, Jennifer, Stevens, Laura J, Agostini, Maria L, Anderson-Daniels, Jordan, Chappell, James D, Lu, Xiaotao, Pruijssers, Andrea J, Routh, Andrew L, Denison, Mark R
Published in PLoS pathogens (19.01.2021)
Published in PLoS pathogens (19.01.2021)
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Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV
Sheahan, Timothy P., Sims, Amy C., Leist, Sarah R., Schäfer, Alexandra, Won, John, Brown, Ariane J., Montgomery, Stephanie A., Hogg, Alison, Babusis, Darius, Clarke, Michael O., Spahn, Jamie E., Bauer, Laura, Sellers, Scott, Porter, Danielle, Feng, Joy Y., Cihlar, Tomas, Jordan, Robert, Denison, Mark R., Baric, Ralph S.
Published in Nature Communications (10.01.2020)
Published in Nature Communications (10.01.2020)
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Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen
Pallesen, Jesper, Wang, Nianshuang, Corbett, Kizzmekia S., Wrapp, Daniel, Kirchdoerfer, Robert N., Turner, Hannah L., Cottrell, Christopher A., Becker, Michelle M., Wang, Lingshu, Shi, Wei, Kong, Wing-Pui, Andres, Erica L., Kettenbach, Arminja N., Denison, Mark R., Chappell, James D., Graham, Barney S., Ward, Andrew B., McLellan, Jason S.
Published in Proceedings of the National Academy of Sciences - PNAS (29.08.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (29.08.2017)
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Sheahan, Timothy P, Sims, Amy C, Graham, Rachel L, Menachery, Vineet D, Gralinski, Lisa E, Case, James B, Leist, Sarah R, Pyrc, Krzysztof, Feng, Joy Y, Trantcheva, Iva, Bannister, Roy, Park, Yeojin, Babusis, Darius, Clarke, Michael O, Mackman, Richard L, Spahn, Jamie E, Palmiotti, Christopher A, Siegel, Dustin, Ray, Adrian S, Cihlar, Tomas, Jordan, Robert, Denison, Mark R, Baric, Ralph S
Published in Science translational medicine (28.06.2017)
Published in Science translational medicine (28.06.2017)
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Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Agostini, Maria L, Andres, Erica L, Sims, Amy C, Graham, Rachel L, Sheahan, Timothy P, Lu, Xiaotao, Smith, Everett Clinton, Case, James Brett, Feng, Joy Y, Jordan, Robert, Ray, Adrian S, Cihlar, Tomas, Siegel, Dustin, Mackman, Richard L, Clarke, Michael O, Baric, Ralph S, Denison, Mark R
Published in mBio (06.03.2018)
Published in mBio (06.03.2018)
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Infidelity of SARS-CoV Nsp14-exonuclease mutant virus replication is revealed by complete genome sequencing
Eckerle, Lance D, Becker, Michelle M, Halpin, Rebecca A, Li, Kelvin, Venter, Eli, Lu, Xiaotao, Scherbakova, Sana, Graham, Rachel L, Baric, Ralph S, Stockwell, Timothy B, Spiro, David J, Denison, Mark R
Published in PLoS pathogens (01.05.2010)
Published in PLoS pathogens (01.05.2010)
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Coronaviruses: An RNA proofreading machine regulates replication fidelity and diversity
Denison, Mark R., Graham, Rachel L., Donaldson, Eric F., Eckerle, Lance D., Baric, Ralph S.
Published in RNA biology (01.03.2011)
Published in RNA biology (01.03.2011)
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Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape
Wang, Lingshu, Shi, Wei, Chappell, James D, Joyce, M Gordon, Zhang, Yi, Kanekiyo, Masaru, Becker, Michelle M, van Doremalen, Neeltje, Fischer, Robert, Wang, Nianshuang, Corbett, Kizzmekia S, Choe, Misook, Mason, Rosemarie D, Van Galen, Joseph G, Zhou, Tongqing, Saunders, Kevin O, Tatti, Kathleen M, Haynes, Lia M, Kwong, Peter D, Modjarrad, Kayvon, Kong, Wing-Pui, McLellan, Jason S, Denison, Mark R, Munster, Vincent J, Mascola, John R, Graham, Barney S
Published in Journal of virology (15.05.2018)
Published in Journal of virology (15.05.2018)
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Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity
Case, James Brett, Li, Yize, Elliott, Ruth, Lu, Xiaotao, Graepel, Kevin W, Sexton, Nicole R, Smith, Everett Clinton, Weiss, Susan R, Denison, Mark R
Published in Journal of virology (01.01.2018)
Published in Journal of virology (01.01.2018)
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Stabilized coronavirus spike stem elicits a broadly protective antibody
Hsieh, Ching-Lin, Werner, Anne P., Leist, Sarah R., Stevens, Laura J., Falconer, Ester, Goldsmith, Jory A., Chou, Chia-Wei, Abiona, Olubukola M., West, Ande, Westendorf, Kathryn, Muthuraman, Krithika, Fritch, Ethan J., Dinnon, Kenneth H., Schäfer, Alexandra, Denison, Mark R., Chappell, James D., Baric, Ralph S., Graham, Barney S., Corbett, Kizzmekia S., McLellan, Jason S.
Published in Cell reports (Cambridge) (02.11.2021)
Published in Cell reports (Cambridge) (02.11.2021)
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High Fidelity of Murine Hepatitis Virus Replication Is Decreased in nsp14 Exoribonuclease Mutants
ECKERLE, Lance D, XIAOTAO LU, SPERRY, Steven M, CHOI, Leena, DENISON, Mark R
Published in Journal of Virology (01.11.2007)
Published in Journal of Virology (01.11.2007)
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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus
Huang, I-Chueh, Bailey, Charles C, Weyer, Jessica L, Radoshitzky, Sheli R, Becker, Michelle M, Chiang, Jessica J, Brass, Abraham L, Ahmed, Asim A, Chi, Xiaoli, Dong, Lian, Longobardi, Lindsay E, Boltz, Dutch, Kuhn, Jens H, Elledge, Stephen J, Bavari, Sina, Denison, Mark R, Choe, Hyeryun, Farzan, Michael
Published in PLoS pathogens (01.01.2011)
Published in PLoS pathogens (01.01.2011)
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A mutation in the coronavirus nsp13-helicase impairs enzymatic activity and confers partial remdesivir resistance
Grimes, Samantha L, Choi, Young J, Banerjee, Anoosha, Small, Gabriel, Anderson-Daniels, Jordan, Gribble, Jennifer, Pruijssers, Andrea J, Agostini, Maria L, Abu-Shmais, Alexandra, Lu, Xiaotao, Darst, Seth A, Campbell, Elizabeth, Denison, Mark R
Published in mBio (31.08.2023)
Published in mBio (31.08.2023)
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Reovirus RNA recombination is sequence directed and generates internally deleted defective genome segments during passage
Smith, Sydni Caet, Gribble, Jennifer, Diller, Julia R, Wiebe, Michelle A, Thoner, Jr, Timothy W, Denison, Mark R, Ogden, Kristen M
Published in Journal of virology (25.03.2021)
Published in Journal of virology (25.03.2021)
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Chimeric Exchange of Coronavirus nsp5 Proteases (3CLpro) Identifies Common and Divergent Regulatory Determinants of Protease Activity
Stobart, Christopher C, Sexton, Nicole R, Munjal, Havisha, Lu, Xiaotao, Molland, Katrina L, Tomar, Sakshi, Mesecar, Andrew D, Denison, Mark R
Published in Journal of Virology (01.12.2013)
Published in Journal of Virology (01.12.2013)
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Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD
Wang, Nianshuang, Rosen, Osnat, Wang, Lingshu, Turner, Hannah L., Stevens, Laura J., Corbett, Kizzmekia S., Bowman, Charles A., Pallesen, Jesper, Shi, Wei, Zhang, Yi, Leung, Kwanyee, Kirchdoerfer, Robert N., Becker, Michelle M., Denison, Mark R., Chappell, James D., Ward, Andrew B., Graham, Barney S., McLellan, Jason S.
Published in Cell Reports (24.09.2019)
Published in Cell Reports (24.09.2019)
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Mutations across murine hepatitis virus nsp4 alter virus fitness and membrane modifications
Beachboard, Dia C, Anderson-Daniels, Jordan M, Denison, Mark R
Published in Journal of virology (01.02.2015)
Published in Journal of virology (01.02.2015)
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