Solubility-Driven Optimization of Phosphodiesterase‑4 Inhibitors Leading to a Clinical Candidate
Press, Neil J, Taylor, Roger J, Fullerton, Joseph D, Tranter, Pamela, McCarthy, Clive, Keller, Thomas H, Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I, Keenan, Mark, Mercer, Mark K, Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R, Tweed, Morris, Tyler, John W, Wagner, Trixie, Fozard, John R, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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The Synthesis of Azadirachtin: A Potent Insect Antifeedant
Ley, Steven V., Abad-Somovilla, Antonio, Anderson, James C., Ayats, Carles, Bänteli, Rolf, Beckmann, Edith, Boyer, Alistair, Brasca, Maria G., Brice, Abigail, Broughton, Howard B., Burke, Brenda J., Cleator, Ed, Craig, Donald, Denholm, Alastair A., Denton, Ross M., Durand-Reville, Thomas, Gobbi, Luca B., Göbel, Michael, Gray, Brian Lawrence, Grossmann, Robert B., Gutteridge, Claire E., Hahn, Norbert, Harding, Sarah L., Jennens, David C., Jennens, Lynn, Lovell, Peter J., Lovell, Helen J., de la Puente, Mary L., Kolb, Hartmuth C., Koot, Win-Jan, Maslen, Sarah L., McCusker, Catherine F., Mattes, Amos, Pape, Andrew R., Pinto, Andrea, Santafianos, Dinos, Scott, James S., Smith, Stephen C., Somers, Andrew Q., Spilling, Christopher D., Stelzer, Frank, Toogood, Peter L., Turner, Richard M., Veitch, Gemma E., Wood, Anthony, Zumbrunn, Cornelia
Published in Chemistry : a European journal (26.11.2008)
Published in Chemistry : a European journal (26.11.2008)
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Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists
Cole, Andrew G., Metzger, Axel, Brescia, Marc-Raleigh, Qin, Lan-Ying, Appell, Kenneth C., Brain, Christopher T., Hallett, Allan, Ganju, Pam, Denholm, Alastair A., Wareing, James R., Ritchie, Timothy J., Drake, Gillian M., Bevan, Stuart J., MacGloinn, Aisling, McBryde, Andrew, Patel, Viral, Oakley, Paul J., Nunez, Ximena, Gstach, Hubert, Schneider, Peter, Baldwin, John J., Dolle, Roland E., McDonald, Edward, Henderson, Ian
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 1
Furet, Pascal, Caravatti, Giorgio, Denholm, Alastair A, Faessler, Alex, Fretz, Heinz, Garcı́a-Echeverrı́a, Carlos, Gay, Brigitte, Irving, Ed, Press, Neil J, Rahuel, Joseph, Schoepfer, Joseph, Walker, Clive V
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Structure-based design and synthesis of phosphinate isosteres of phosphotyrosine for incorporation in Grb2-SH2 domain inhibitors. Part 2
Walker, Clive V, Caravatti, Giorgio, Denholm, Alastair A, Egerton, John, Faessler, Alex, Furet, Pascal, Garcı́a-Echeverrı́a, Carlos, Gay, Brigitte, Irving, Ed, Jones, Ken, Lambert, Amanda, Press, Neil J, Woods, John
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
Published in Bioorganic & medicinal chemistry letters (16.10.2000)
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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Discovery and Optimization of 4‑(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD)
Press, Neil J., Taylor, Roger J., Fullerton, Joseph D., Tranter, Pamela, McCarthy, Clive, Keller, Thomas H., Arnold, Nicola, Beer, David, Brown, Lyndon, Cheung, Robert, Christie, Julie, Denholm, Alastair, Haberthuer, Sandra, Hatto, Julia D. I., Keenan, Mark, Mercer, Mark K., Oakman, Helen, Sahri, Helene, Tuffnell, Andrew R., Tweed, Morris, Trifilieff, Alexandre
Published in Journal of medicinal chemistry (10.09.2015)
Published in Journal of medicinal chemistry (10.09.2015)
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Pyrrolizidine alkaloid biosynthesis. Synthesis of N-([4-14C]-4-aminobutyl)-1,2-didehydropyrrolidinium and its incorporation into different pyrrolizidine bases (necines)
Denholm, Alastair A., Kelly, Henry A., Robins, David J.
Published in Journal of the Chemical Society, Perkin Transactions 1 (1991)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1991)
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Cover Picture: The Synthesis of Azadirachtin: A Potent Insect Antifeedant (Chem. Eur. J. 34/2008)
Ley, Steven V., Abad-Somovilla, Antonio, Anderson, James C., Ayats, Carles, Bänteli, Rolf, Beckmann, Edith, Boyer, Alistair, Brasca, Maria G., Brice, Abigail, Broughton, Howard B., Burke, Brenda J., Cleator, Ed, Craig, Donald, Denholm, Alastair A., Denton, Ross M., Durand-Reville, Thomas, Gobbi, Luca B., Göbel, Michael, Gray, Brian Lawrence, Grossmann, Robert B., Gutteridge, Claire E., Hahn, Norbert, Harding, Sarah L., Jennens, David C., Jennens, Lynn, Lovell, Peter J., Lovell, Helen J., de la Puente, Mary L., Kolb, Hartmuth C., Koot, Win-Jan, Maslen, Sarah L., McCusker, Catherine F., Mattes, Amos, Pape, Andrew R., Pinto, Andrea, Santafianos, Dinos, Scott, James S., Smith, Stephen C., Somers, Andrew Q., Spilling, Christopher D., Stelzer, Frank, Toogood, Peter L., Turner, Richard M., Veitch, Gemma E., Wood, Anthony, Zumbrunn, Cornelia
Published in Chemistry : a European journal (26.11.2008)
Published in Chemistry : a European journal (26.11.2008)
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Journal Article
Sexual development of malaria parasites is inhibited in vitro by the Neem extract Azadirachtin, and its semi‐synthetic analogues
Jones, Ian W., Denholm, Alastair A., Ley, Steven V., Lovell, Helen, Wood, Anthony, Sinden, Robert E.
Published in FEMS microbiology letters (15.07.1994)
Published in FEMS microbiology letters (15.07.1994)
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Journal Article
2-Aminopyrimidine derivatives and their medical use
BOLLBUCK, BIRGIT, WÄLCHLI, RUDOLF, DENHOLM, ALASTAIR, HERSPERGER, RENÉ, JANSER, PHILIPP, EDER, JÖRG, SCHLAPBACH, ACHIM, RÉVÉSZ, LÁSZLO
Year of Publication 29.10.2014
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Year of Publication 29.10.2014
Patent
PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION
KELLEHER, PATRICK, DAVIES, SIMON, DENHOLM, ALASTAIR, ALEXANDER, TULLY, WILLIAM, EUGENE
Year of Publication 11.05.2011
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Year of Publication 11.05.2011
Patent
PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION
KELLEHER, PATRICK, DAVIES, SIMON, DENHOLM, ALASTAIR, ALEXANDER, TULLY, WILLIAM, EUGENE
Year of Publication 05.12.2007
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Year of Publication 05.12.2007
Patent
PREPARATION OF AN ATORVASTATIN INTERMEDIATE USING A PAAL-KNORR CONDENSATION
KELLEHER, PATRICK, DAVIES, SIMON, DENHOLM, ALASTAIR, ALEXANDER, TULLY, WILLIAM, EUGENE
Year of Publication 21.09.2006
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Year of Publication 21.09.2006
Patent