Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro
Köppen, Janett, Schulze, Anja, Machner, Lisa, Wermann, Michael, Eichentopf, Rico, Guthardt, Max, Hähnel, Angelika, Klehm, Jessica, Kriegeskorte, Marie-Christin, Hartlage-Rübsamen, Maike, Morawski, Markus, von Hörsten, Stephan, Demuth, Hans-Ulrich, Roßner, Steffen, Schilling, Stephan
Published in Molecules (Basel, Switzerland) (29.01.2020)
Published in Molecules (Basel, Switzerland) (29.01.2020)
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Posttranslational modification impact on the mechanism by which amyloid‐β induces synaptic dysfunction
Grochowska, Katarzyna M, Yuanxiang, PingAn, Bär, Julia, Raman, Rajeev, Brugal, Gemma, Sahu, Giriraj, Schweizer, Michaela, Bikbaev, Arthur, Schilling, Stephan, Demuth, Hans‐Ulrich, Kreutz, Michael R
Published in EMBO reports (01.06.2017)
Published in EMBO reports (01.06.2017)
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N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation
Schlenzig, Dagmar, Rönicke, Raik, Cynis, Holger, Ludwig, Hans-Henning, Scheel, Eike, Reymann, Klaus, Saido, Takaomi, Hause, Gerd, Schilling, Stephan, Demuth, Hans-Ulrich
Published in Journal of neurochemistry (01.06.2012)
Published in Journal of neurochemistry (01.06.2012)
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Natural Products from Microalgae with Potential against Alzheimer's Disease: Sulfolipids Are Potent Glutaminyl Cyclase Inhibitors
Hielscher-Michael, Stephanie, Griehl, Carola, Buchholz, Mirko, Demuth, Hans-Ulrich, Arnold, Norbert, Wessjohann, Ludger A
Published in Marine drugs (02.11.2016)
Published in Marine drugs (02.11.2016)
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Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides
Schlenzig, Dagmar, Manhart, Susanne, Cinar, Yeliz, Kleinschmidt, Martin, Hause, Gerd, Willbold, Dieter, Funke, Susanne Aileen, Schilling, Stephan, Demuth, Hans-Ulrich
Published in Biochemistry (Easton) (28.07.2009)
Published in Biochemistry (Easton) (28.07.2009)
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Kallikrein‐related peptidases are activators of the CC chemokine CCL14
Grünberg, Mario, Quandt, Dagmar, Cynis, Holger, Demuth, Hans‐Ulrich, Kindermann, Andrea, Magdolen, Viktor, Forssmann, Wolf‐Georg, Seliger, Barbara, Mägert, Hans‐Jürgen
Published in European journal of immunology (01.09.2018)
Published in European journal of immunology (01.09.2018)
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QUINT: Workflow for Quantification and Spatial Analysis of Features in Histological Images From Rodent Brain
Yates, Sharon C, Groeneboom, Nicolaas E, Coello, Christopher, Lichtenthaler, Stefan F, Kuhn, Peer-Hendrik, Demuth, Hans-Ulrich, Hartlage-Rübsamen, Maike, Roßner, Steffen, Leergaard, Trygve, Kreshuk, Anna, Puchades, Maja A, Bjaalie, Jan G
Published in Frontiers in neuroinformatics (03.12.2019)
Published in Frontiers in neuroinformatics (03.12.2019)
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Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor
Parthier, Christoph, Kleinschmidt, Martin, Neumann, Piotr, Rudolph, Rainer, Manhart, Susanne, Schlenzig, Dagmar, Fanghänel, Jörg, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich, Stubbs, Milton T
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (28.08.2007)
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Journal Article
Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides
Wulff, Melanie, Baumann, Monika, Thümmler, Anka, Yadav, Jay K., Heinrich, Liesa, Knüpfer, Uwe, Schlenzig, Dagmar, Schierhorn, Angelika, Rahfeld, Jens-Ulrich, Horn, Uwe, Balbach, Jochen, Demuth, Hans-Ulrich, Fändrich, Marcus
Published in Angewandte Chemie International Edition (11.04.2016)
Published in Angewandte Chemie International Edition (11.04.2016)
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Structure and Dynamics of Meprin β in Complex with a Hydroxamate-Based Inhibitor
Linnert, Miriam, Fritz, Claudia, Jäger, Christian, Schlenzig, Dagmar, Ramsbeck, Daniel, Kleinschmidt, Martin, Wermann, Michael, Demuth, Hans-Ulrich, Parthier, Christoph, Schilling, Stephan
Published in International journal of molecular sciences (26.05.2021)
Published in International journal of molecular sciences (26.05.2021)
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Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution
Schilling, Stephan, Wasternack, Claus, Demuth, Hans-Ulrich
Published in Biological chemistry (01.08.2008)
Published in Biological chemistry (01.08.2008)
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Journal Article
N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity
Kehlen, Astrid, Haegele, Monique, Böhme, Livia, Cynis, Holger, Hoffmann, Torsten, Demuth, Hans-Ulrich
Published in Bioscience reports (31.08.2017)
Published in Bioscience reports (31.08.2017)
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Journal Article
Purification and Characterization of Recombinant N-Terminally Pyroglutamate-Modified Amyloid-β Variants and Structural Analysis by Solution NMR Spectroscopy
Dammers, Christina, Gremer, Lothar, Neudecker, Philipp, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Published in PloS one (05.10.2015)
Published in PloS one (05.10.2015)
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Journal Article
Structural Analysis and Aggregation Propensity of Pyroglutamate Aβ(3-40) in Aqueous Trifluoroethanol
Dammers, Christina, Gremer, Lothar, Reiß, Kerstin, Klein, Antonia N, Neudecker, Philipp, Hartmann, Rudolf, Sun, Na, Demuth, Hans-Ulrich, Schwarten, Melanie, Willbold, Dieter
Published in PloS one (23.11.2015)
Published in PloS one (23.11.2015)
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A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice
Barendrecht, Susan, Schreurs, An, Geissler, Stefanie, Sabanov, Victor, Ilse, Victoria, Rieckmann, Vera, Eichentopf, Rico, Künemund, Anja, Hietel, Benjamin, Wussow, Sebastian, Hoffmann, Katrin, Körber-Ferl, Kerstin, Pandey, Ravi, Carter, Gregory W, Demuth, Hans-Ulrich, Holzer, Max, Roßner, Steffen, Schilling, Stephan, Preuss, Christoph, Balschun, Detlef, Cynis, Holger
Published in Alzheimer's research & therapy (14.01.2023)
Published in Alzheimer's research & therapy (14.01.2023)
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The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
Cynis, Holger, Hoffmann, Torsten, Friedrich, Daniel, Kehlen, Astrid, Gans, Kathrin, Kleinschmidt, Martin, Rahfeld, Jens‐Ulrich, Wolf, Raik, Wermann, Michael, Stephan, Anett, Haegele, Monique, Sedlmeier, Reinhard, Graubner, Sigrid, Jagla, Wolfgang, Müller, Anke, Eichentopf, Rico, Heiser, Ulrich, Seifert, Franziska, Quax, Paul H. A., de Vries, Margreet R., Hesse, Isabel, Trautwein, Daniela, Wollert, Ulrich, Berg, Sabine, Freyse, Ernst‐Joachim, Schilling, Stephan, Demuth, Hans‐Ulrich
Published in EMBO molecular medicine (01.09.2011)
Published in EMBO molecular medicine (01.09.2011)
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Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1–30 fragment
Wagner, Leona, Björkqvist, Maria, Lundh, Sofia Hult, Wolf, Raik, Börgel, Arne, Schlenzig, Dagmar, Ludwig, Hans‐Henning, Rahfeld, Jens‐Ulrich, Leavitt, Blair, Demuth, Hans‐Ulrich, Petersén, Åsa, Hörsten, Stephan
Published in Journal of neurochemistry (01.06.2016)
Published in Journal of neurochemistry (01.06.2016)
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The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals Its Functional Regulation and Enzymatic Mechanism
Engel, Michael, Hoffmann, Torsten, Wagner, Leona, Wermann, Michael, Heiser, Ulrich, Kiefersauer, Reiner, Huber, Robert, Bode, Wolfram, Demuth, Hans-Ulrich, Brandstetter, Hans
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2003)
Published in Proceedings of the National Academy of Sciences - PNAS (29.04.2003)
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Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation
Hartlage-Rübsamen, Maike, Bluhm, Alexandra, Piechotta, Anke, Linnert, Miriam, Rahfeld, Jens-Ulrich, Demuth, Hans-Ulrich, Lues, Inge, Kuhn, Peer-Hendrik, Lichtenthaler, Stefan F, Roßner, Steffen, Höfling, Corinna
Published in Molecules (Basel, Switzerland) (17.04.2018)
Published in Molecules (Basel, Switzerland) (17.04.2018)
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