Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials
Tsebriy, Oleksiy, Khomiak, Andrii, Miguel-Blanco, Celia, Sparkes, Penny C, Gioli, Maurizio, Santelli, Marco, Whitley, Edgar, Gamo, Francisco-Javier, Delves, Michael J
Published in PLoS pathogens (01.10.2023)
Published in PLoS pathogens (01.10.2023)
Get full text
Journal Article
Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions
Delves, Michael J, Straschil, Ursula, Ruecker, Andrea, Miguel-Blanco, Celia, Marques, Sara, Dufour, Alexandre C, Baum, Jake, Sinden, Robert E
Published in Nature protocols (01.09.2016)
Published in Nature protocols (01.09.2016)
Get full text
Journal Article
Male and Female Plasmodium falciparum Mature Gametocytes Show Different Responses to Antimalarial Drugs
DELVES, Michael J, RUECKER, Andrea, STRASCHIL, Ursula, LELIEVRE, Jöel, MARQUES, Sara, LOPEZ-BARRAGAN, María José, HERREROS, Esperanza, SINDEN, Robert E
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Get full text
Journal Article
The antimalarial screening landscape—looking beyond the asexual blood stage
Yahiya, Sabrina, Rueda-Zubiaurre, Ainoa, Delves, Michael J, Fuchter, Matthew J, Baum, Jake
Published in Current opinion in chemical biology (01.06.2019)
Published in Current opinion in chemical biology (01.06.2019)
Get full text
Journal Article
A high throughput screen for next-generation leads targeting malaria parasite transmission
Delves, Michael J., Miguel-Blanco, Celia, Matthews, Holly, Molina, Irene, Ruecker, Andrea, Yahiya, Sabrina, Straschil, Ursula, Abraham, Matthew, León, María Luisa, Fischer, Oliver J., Rueda-Zubiaurre, Ainoa, Brandt, Jochen R., Cortés, Álvaro, Barnard, Anna, Fuchter, Matthew J., Calderón, Félix, Winzeler, Elizabeth A., Sinden, Robert E., Herreros, Esperanza, Gamo, Francisco J., Baum, Jake
Published in Nature communications (18.09.2018)
Published in Nature communications (18.09.2018)
Get full text
Journal Article
The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites
Delves, Michael, Plouffe, David, Scheurer, Christian, Meister, Stephan, Wittlin, Sergio, Winzeler, Elizabeth A, Sinden, Robert E, Leroy, Didier
Published in PLoS medicine (01.02.2012)
Published in PLoS medicine (01.02.2012)
Get full text
Journal Article
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Baragaña, Beatriz, Hallyburton, Irene, Lee, Marcus C. S., Norcross, Neil R., Grimaldi, Raffaella, Otto, Thomas D., Proto, William R., Blagborough, Andrew M., Meister, Stephan, Wirjanata, Grennady, Ruecker, Andrea, Upton, Leanna M., Abraham, Tara S., Almeida, Mariana J., Pradhan, Anupam, Porzelle, Achim, Martínez, María Santos, Bolscher, Judith M., Woodland, Andrew, Luksch, Torsten, Norval, Suzanne, Zuccotto, Fabio, Thomas, John, Simeons, Frederick, Stojanovski, Laste, Osuna-Cabello, Maria, Brock, Paddy M., Churcher, Tom S., Sala, Katarzyna A., Zakutansky, Sara E., Jiménez-Díaz, María Belén, Sanz, Laura Maria, Riley, Jennifer, Basak, Rajshekhar, Campbell, Michael, Avery, Vicky M., Sauerwein, Robert W., Dechering, Koen J., Noviyanti, Rintis, Campo, Brice, Frearson, Julie A., Angulo-Barturen, Iñigo, Ferrer-Bazaga, Santiago, Gamo, Francisco Javier, Wyatt, Paul G., Leroy, Didier, Siegl, Peter, Delves, Michael J., Kyle, Dennis E., Wittlin, Sergio, Marfurt, Jutta, Price, Ric N., Sinden, Robert E., Winzeler, Elizabeth A., Charman, Susan A., Bebrevska, Lidiya, Gray, David W., Campbell, Simon, Fairlamb, Alan H., Willis, Paul A., Rayner, Julian C., Fidock, David A., Read, Kevin D., Gilbert, Ian H.
Published in Nature (London) (18.06.2015)
Published in Nature (London) (18.06.2015)
Get full text
Journal Article
Allele-Specific Isothermal Amplification Method Using Unmodified Self-Stabilizing Competitive Primers
Malpartida-Cardenas, Kenny, Rodriguez-Manzano, Jesus, Yu, Ling-Shan, Delves, Michael J, Nguon, Chea, Chotivanich, Kesinee, Baum, Jake, Georgiou, Pantelis
Published in Analytical chemistry (Washington) (16.10.2018)
Published in Analytical chemistry (Washington) (16.10.2018)
Get full text
Journal Article
Transmission of Artemisinin-Resistant Malaria Parasites to Mosquitoes under Antimalarial Drug Pressure
Witmer, Kathrin, Dahalan, Farah A, Delves, Michael J, Yahiya, Sabrina, Watson, Oliver J, Straschil, Ursula, Chiwcharoen, Darunee, Sornboon, Boodtee, Pukrittayakamee, Sasithon, Pearson, Richard D, Howick, Virginia M, Lawniczak, Mara K N, White, Nicholas J, Dondorp, Arjen M, Okell, Lucy C, Chotivanich, Kesinee, Ruecker, Andrea, Baum, Jake
Published in Antimicrobial agents and chemotherapy (16.12.2020)
Published in Antimicrobial agents and chemotherapy (16.12.2020)
Get full text
Journal Article
Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development
Lamour, Sabrina D, Straschil, Ursula, Saric, Jasmina, Delves, Michael J
Published in Malaria journal (01.12.2014)
Published in Malaria journal (01.12.2014)
Get full text
Journal Article
Structure–Activity Relationship Studies of a Novel Class of Transmission Blocking Antimalarials Targeting Male Gametes
Rueda-Zubiaurre, Ainoa, Yahiya, Sabrina, Fischer, Oliver J, Hu, Xiaojun, Saunders, Charlie N, Sharma, Sachi, Straschil, Ursula, Shen, Junting, Tate, Edward W, Delves, Michael J, Baum, Jake, Barnard, Anna, Fuchter, Matthew J
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
Get full text
Journal Article
Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen
Miguel-Blanco, Celia, Molina, Irene, Bardera, Ana I., Díaz, Beatriz, de las Heras, Laura, Lozano, Sonia, González, Carolina, Rodrigues, Janneth, Delves, Michael J., Ruecker, Andrea, Colmenarejo, Gonzalo, Viera, Sara, Martínez-Martínez, María S., Fernández, Esther, Baum, Jake, Sinden, Robert E., Herreros, Esperanza
Published in Nature communications (17.05.2017)
Published in Nature communications (17.05.2017)
Get full text
Journal Article
Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans
Malmquist, Nicholas A, Sundriyal, Sandeep, Caron, Joachim, Chen, Patty, Witkowski, Benoit, Menard, Didier, Suwanarusk, Rossarin, Renia, Laurent, Nosten, Francois, Jiménez-Díaz, María Belén, Angulo-Barturen, Iñigo, Santos Martínez, María, Ferrer, Santiago, Sanz, Laura M, Gamo, Francisco-Javier, Wittlin, Sergio, Duffy, Sandra, Avery, Vicky M, Ruecker, Andrea, Delves, Michael J, Sinden, Robert E, Fuchter, Matthew J, Scherf, Artur
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Published in Antimicrobial agents and chemotherapy (01.02.2015)
Get full text
Journal Article
Measuring the blockade of malaria transmission – An analysis of the Standard Membrane Feeding Assay
Churcher, Thomas S., Blagborough, Andrew M., Delves, Michael, Ramakrishnan, Chandra, Kapulu, Melissa C., Williams, Andrew R., Biswas, Sumi, Da, Dari F., Cohuet, Anna, Sinden, Robert E.
Published in International journal for parasitology (01.10.2012)
Published in International journal for parasitology (01.10.2012)
Get full text
Journal Article
Protocols for Plasmodium gametocyte production in vitro: an integrative review and analysis
Omorou, Roukayatou, Bin Sa'id, Ibrahim, Delves, Michael, Severini, Carlo, Kouakou, Yobouet Ines, Bienvenu, Anne-Lise, Picot, Stephane
Published in Parasites & vectors (05.12.2022)
Published in Parasites & vectors (05.12.2022)
Get full text
Journal Article
Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages
Delves, Michael, Lafuente-Monasterio, M Jose, Upton, Leanna, Ruecker, Andrea, Leroy, Didier, Gamo, Francisco-Javier, Sinden, Robert
Published in Frontiers in microbiology (13.09.2019)
Published in Frontiers in microbiology (13.09.2019)
Get full text
Journal Article