Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Chamberlain, Philip P, Lopez-Girona, Antonia, Miller, Karen, Carmel, Gilles, Pagarigan, Barbra, Chie-Leon, Barbara, Rychak, Emily, Corral, Laura G, Ren, Yan J, Wang, Maria, Riley, Mariko, Delker, Silvia L, Ito, Takumi, Ando, Hideki, Mori, Tomoyuki, Hirano, Yoshinori, Handa, Hiroshi, Hakoshima, Toshio, Daniel, Thomas O, Cathers, Brian E
Published in Nature structural & molecular biology (01.09.2014)
Published in Nature structural & molecular biology (01.09.2014)
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Journal Article
Structure–Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors
Basak, Sneha, Li, Yong, Tao, Suyuan, Daryaee, Fereidoon, Merino, Jonathan, Gu, Chendi, Delker, Silvia L., Phan, Jenny N., Edwards, Thomas E., Walker, Stephen G., Tonge, Peter J.
Published in Journal of medicinal chemistry (08.09.2022)
Published in Journal of medicinal chemistry (08.09.2022)
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Journal Article
Structural insights into the function of the catalytically active human Taspase1
Nagaratnam, Nirupa, Delker, Silvia L., Jernigan, Rebecca, Edwards, Thomas E., Snider, Janey, Thifault, Darren, Williams, Dewight, Nannenga, Brent L., Stofega, Mary, Sambucetti, Lidia, Hsieh, James J., Flint, Andrew J., Fromme, Petra, Martin-Garcia, Jose M.
Published in Structure (London) (05.08.2021)
Published in Structure (London) (05.08.2021)
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Journal Article
Potent, Highly Selective, and Orally Bioavailable Gem-Difluorinated Monocationic Inhibitors of Neuronal Nitric Oxide Synthase
Xue, Fengtian, Li, Huiying, Delker, Silvia L, Fang, Jianguo, Martásek, Pavel, Roman, Linda J, Poulos, Thomas L, Silverman, Richard B
Published in Journal of the American Chemical Society (13.10.2010)
Published in Journal of the American Chemical Society (13.10.2010)
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Journal Article
Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model
Delker, Silvia L, Ji, Haitao, Li, Huiying, Jamal, Joumana, Fang, Jianguo, Xue, Fengtian, Silverman, Richard B, Poulos, Thomas L
Published in Journal of the American Chemical Society (21.04.2010)
Published in Journal of the American Chemical Society (21.04.2010)
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Journal Article
Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor
Plantevin Krenitsky, Véronique, Nadolny, Lisa, Delgado, Mercedes, Ayala, Leticia, Clareen, Steven S., Hilgraf, Robert, Albers, Ronald, Hegde, Sayee, D’Sidocky, Neil, Sapienza, John, Wright, Jonathan, McCarrick, Meg, Bahmanyar, Sogole, Chamberlain, Philip, Delker, Silvia L., Muir, Jeff, Giegel, David, Xu, Li, Celeridad, Maria, Lachowitzer, Jeff, Bennett, Brydon, Moghaddam, Mehran, Khatsenko, Oleg, Katz, Jason, Fan, Rachel, Bai, April, Tang, Yang, Shirley, Michael A., Benish, Brent, Bodine, Tracey, Blease, Kate, Raymon, Heather, Cathers, Brian E., Satoh, Yoshitaka
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
Published in Bioorganic & medicinal chemistry letters (01.02.2012)
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Journal Article
Role of Zinc in Isoform-Selective Inhibitor Binding to Neuronal Nitric Oxide Synthase
Delker, Silvia L, Xue, Fengtian, Li, Huiying, Jamal, Joumana, Silverman, Richard B, Poulos, Thomas L
Published in Biochemistry (Easton) (28.12.2010)
Published in Biochemistry (Easton) (28.12.2010)
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Journal Article
Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives
Ji, Haitao, Delker, Silvia L, Li, Huiying, Martásek, Pavel, Roman, Linda J, Poulos, Thomas L, Silverman, Richard B
Published in Journal of medicinal chemistry (11.11.2010)
Published in Journal of medicinal chemistry (11.11.2010)
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Journal Article
Symmetric Double-Headed Aminopyridines, a Novel Strategy for Potent and Membrane-Permeable Inhibitors of Neuronal Nitric Oxide Synthase
Xue, Fengtian, Fang, Jianguo, Delker, Silvia L, Li, Huiying, Martásek, Pavel, Roman, Linda J, Poulos, Thomas L, Silverman, Richard B
Published in Journal of medicinal chemistry (14.04.2011)
Published in Journal of medicinal chemistry (14.04.2011)
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Journal Article
Extension of Drosophila melanogaster life span with a GPCR peptide inhibitor
Roberts, Richard W, Ja, William W, West, Anthony P, Delker, Silvia L, Bjorkman, Pamela J, Benzer, Seymour
Published in Nature chemical biology (01.07.2007)
Published in Nature chemical biology (01.07.2007)
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Journal Article
Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase
Li, Huiying, Xue, Fengtian, Kraus, James M., Ji, Haitao, Labby, Kristin Jansen, Mataka, Jan, Delker, Silvia L., Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Published in Bioorganic & medicinal chemistry (01.03.2013)
Published in Bioorganic & medicinal chemistry (01.03.2013)
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Journal Article
Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase
Xue, Fengtian, Kraus, James M, Labby, Kristin Jansen, Ji, Haitao, Mataka, Jan, Xia, Guoyao, Li, Huiying, Delker, Silvia L, Roman, Linda J, Martásek, Pavel, Poulos, Thomas L, Silverman, Richard B
Published in Journal of medicinal chemistry (22.09.2011)
Published in Journal of medicinal chemistry (22.09.2011)
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Journal Article
Unexpected Binding Modes of Nitric Oxide Synthase Inhibitors Effective in the Prevention of a Cerebral Palsy Phenotype in an Animal Model
Delker, Silvia L, Ji, Haitao, Li, Huiying, Jamal, Joumana, Fang, Jianguo, Xue, Fengtian, Silverman, Richard B, Poulos, Thomas L
Published in Journal of the American Chemical Society (20.10.2010)
Published in Journal of the American Chemical Society (20.10.2010)
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Journal Article
항체
LIGHTWOOD DANIEL JOHN, BHATTA PALLAVI, SPILIOTOPOULOS ANASTASIOS, KEANEY JAMES MARTIN, ABENDROTH JAN, KADIU IRENA, DELKER SILVIA L, ELLIOTT PETER CHARLES
Year of Publication 11.01.2024
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Year of Publication 11.01.2024
Patent
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
Tillery, Logan, Barrett, Kayleigh, Goldstein, Jenna, Lassner, Jared W, Osterhout, Bram, Tran, Nathan L, Xu, Lily, Young, Ryan M, Craig, Justin, Chun, Ian, Dranow, David M, Abendroth, Jan, Delker, Silvia L, Davies, Douglas R, Mayclin, Stephen J, Calhoun, Brandy, Bolejack, Madison J, Staker, Bart, Subramanian, Sandhya, Phan, Isabelle, Lorimer, Donald D, Myler, Peter J, Edwards, Thomas E, Kyle, Dennis E, Rice, Christopher A, Morris, James C, Leahy, James W, Manetsch, Roman, Barrett, Lynn K, Smith, Craig L, Van Voorhis, Wesley C
Published in PloS one (24.03.2021)
Published in PloS one (24.03.2021)
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Journal Article
Crystallographic studies of ligand binding by Zn-α2-glycoprotein
Delker, Silvia L., West, Anthony P., McDermott, Lindsay, Kennedy, Malcolm W., Bjorkman, Pamela J.
Published in Journal of structural biology (01.11.2004)
Published in Journal of structural biology (01.11.2004)
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Journal Article
Extension of Drosophila melanogaster lifespan with a GPCR peptide inhibitor
Ja, William W., West, Anthony P., Delker, Silvia L., Bjorkman, Pamela J., Benzer, Seymour, Roberts, Richard W.
Published in Nature chemical biology (03.06.2007)
Published in Nature chemical biology (03.06.2007)
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Journal Article
ANTIBODIES
LIGHTWOOD, Daniel John, SPILIOTOPOULOS, Anastasios, KEANEY, James Martin, ABENDROTH, Jan, DELKER, Silvia L, KADIU, Irena, BHATTA, Pallavi, ELLIOTT, Peter Charles
Year of Publication 01.08.2024
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Year of Publication 01.08.2024
Patent
Crystallographic studies of ligand binding by Zn-alpha2-glycoprotein
Delker, Silvia L, West, Jr, Anthony P, McDermott, Lindsay, Kennedy, Malcolm W, Bjorkman, Pamela J
Published in Journal of structural biology (01.11.2004)
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Published in Journal of structural biology (01.11.2004)
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