Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions
Menk, Ashley V., Scharping, Nicole E., Moreci, Rebecca S., Zeng, Xue, Guy, Cliff, Salvatore, Sonia, Bae, Heekyong, Xie, Jianxin, Young, Howard A., Wendell, Stacy Gelhaus, Delgoffe, Greg M.
Published in Cell reports (Cambridge) (06.02.2018)
Published in Cell reports (Cambridge) (06.02.2018)
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Hypoxia drives CD39-dependent suppressor function in exhausted T cells to limit antitumor immunity
Vignali, Paolo D. A., DePeaux, Kristin, Watson, McLane J., Ye, Chenxian, Ford, B. Rhodes, Lontos, Konstantinos, McGaa, Nicole K., Scharping, Nicole E., Menk, Ashley V., Robson, Simon C., Poholek, Amanda C., Rivadeneira, Dayana B., Delgoffe, Greg M.
Published in Nature immunology (01.02.2023)
Published in Nature immunology (01.02.2023)
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Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis
Weisel, Florian J., Mullett, Steven J., Elsner, Rebecca A., Menk, Ashley V., Trivedi, Nikita, Luo, Wei, Wikenheiser, Daniel, Hawse, William F., Chikina, Maria, Smita, Shuchi, Conter, Laura J., Joachim, Stephen M., Wendell, Stacy G., Jurczak, Michael J., Winkler, Thomas H., Delgoffe, Greg M., Shlomchik, Mark J.
Published in Nature immunology (01.03.2020)
Published in Nature immunology (01.03.2020)
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Journal Article
IL-23 and IL-1β Drive Human Th17 Cell Differentiation and Metabolic Reprogramming in Absence of CD28 Costimulation
Revu, Shankar, Wu, Jing, Henkel, Matthew, Rittenhouse, Natalie, Menk, Ashley, Delgoffe, Greg M., Poholek, Amanda C., McGeachy, Mandy J.
Published in Cell reports (Cambridge) (06.03.2018)
Published in Cell reports (Cambridge) (06.03.2018)
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The composition and signaling of the IL-35 receptor are unconventional
Collison, Lauren W, Delgoffe, Greg M, Guy, Clifford S, Vignali, Kate M, Chaturvedi, Vandana, Fairweather, DeLisa, Satoskar, Abhay R, Garcia, K Christopher, Hunter, Christopher A, Drake, Charles G, Murray, Peter J, Vignali, Dario A A
Published in Nature immunology (01.03.2012)
Published in Nature immunology (01.03.2012)
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The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction
Scharping, Nicole E., Menk, Ashley V., Moreci, Rebecca S., Whetstone, Ryan D., Dadey, Rebekah E., Watkins, Simon C., Ferris, Robert L., Delgoffe, Greg M.
Published in Immunity (Cambridge, Mass.) (20.09.2016)
Published in Immunity (Cambridge, Mass.) (20.09.2016)
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Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck
Zandberg, Dan P, Menk, Ashley V, Velez, Maria, Normolle, Daniel, DePeaux, Kristin, Liu, Angen, Ferris, Robert L, Delgoffe, Greg M
Published in Journal for immunotherapy of cancer (01.05.2021)
Published in Journal for immunotherapy of cancer (01.05.2021)
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Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment
Banerjee, Hridesh, Nieves-Rosado, Hector, Kulkarni, Aditi, Murter, Benjamin, McGrath, Kyle V., Chandran, Uma R., Chang, Alexander, Szymczak-Workman, Andrea L., Vujanovic, Lazar, Delgoffe, Greg M., Ferris, Robert L., Kane, Lawrence P.
Published in Cell reports (Cambridge) (14.09.2021)
Published in Cell reports (Cambridge) (14.09.2021)
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Tumor Microenvironment Metabolism: A New Checkpoint for Anti-Tumor Immunity
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Book Review
Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells
Previte, Dana M., Martins, Christina P., O’Connor, Erin C., Marre, Meghan L., Coudriet, Gina M., Beck, Noah W., Menk, Ashley V., Wright, Rebecca H., Tse, Hubert M., Delgoffe, Greg M., Piganelli, Jon D.
Published in Cell reports (Cambridge) (02.04.2019)
Published in Cell reports (Cambridge) (02.04.2019)
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Checkpoint molecules coordinately restrain hyperactivated effector T cells in the tumor microenvironment
Yang, Min, Du, Wenwen, Yi, Lixian, Wu, Shaoxian, He, Chunyan, Zhai, Wensi, Yue, Cuihua, Sun, Runzi, Menk, Ashley V., Delgoffe, Greg M., Jiang, Jingting, Lu, Binfeng
Published in Oncoimmunology (01.01.2020)
Published in Oncoimmunology (01.01.2020)
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IRF1 Inhibits Antitumor Immunity through the Upregulation of PD-L1 in the Tumor Cell
Shao, Lulu, Hou, Weizhou, Scharping, Nicole E, Vendetti, Frank P, Srivastava, Rashmi, Roy, Chandra Nath, Menk, Ashley V, Wang, Yiyang, Chauvin, Joe-Marc, Karukonda, Pooja, Thorne, Stephen H, Hornung, Veit, Zarour, Hassane M, Bakkenist, Christopher J, Delgoffe, Greg M, Sarkar, Saumendra N
Published in Cancer immunology research (01.08.2019)
Published in Cancer immunology research (01.08.2019)
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Metabolic reprogramming via an engineered PGC-1α improves human chimeric antigen receptor T-cell therapy against solid tumors
Lontos, Konstantinos, Wang, Yiyang, Joshi, Supriya K, Frisch, Andrew T, Watson, McLane J, Kumar, Alok, Menk, Ashley V, Wang, Yupeng, Cumberland, Rachel, Lohmueller, Jason, Carrizosa, Esteban, Boyerinas, Benjamin, Delgoffe, Greg M
Published in Journal for immunotherapy of cancer (01.03.2023)
Published in Journal for immunotherapy of cancer (01.03.2023)
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Interferon signaling drives epithelial metabolic reprogramming to promote secondary bacterial infection
Carreno-Florez, Grace P, Kocak, Brian R, Hendricks, Matthew R, Melvin, Jeffrey A, Mar, Katrina B, Kosanovich, Jessica, Cumberland, Rachel L, Delgoffe, Greg M, Shiva, Sruti, Empey, Kerry M, Schoggins, John W, Bomberger, Jennifer M
Published in PLoS pathogens (01.11.2023)
Published in PLoS pathogens (01.11.2023)
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Antiviral epithelial-macrophage crosstalk permits secondary bacterial infections
Lane, Sidney, White, Tristan L A, Walsh, Erin E, Cattley, Richard T, Cumberland, Rachel, Hawse, William F, Delgoffe, Greg M, Badylak, Stephen F, Bomberger, Jennifer M
Published in mBio (31.10.2023)
Published in mBio (31.10.2023)
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