Discovery of AMG 232, a Potent, Selective, and Orally Bioavailable MDM2–p53 Inhibitor in Clinical Development
Sun, Daqing, Li, Zhihong, Rew, Yosup, Gribble, Michael, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chen, Xiaoqi, Chow, David, Deignan, Jeffrey, Duquette, Jason, Eksterowicz, John, Fisher, Benjamin, Fox, Brian M, Fu, Jiasheng, Gonzalez, Ana Z, Gonzalez-Lopez De Turiso, Felix, Houze, Jonathan B, Huang, Xin, Jiang, Min, Jin, Lixia, Kayser, Frank, Liu, Jiwen (Jim), Lo, Mei-Chu, Long, Alexander M, Lucas, Brian, McGee, Lawrence R, McIntosh, Joel, Mihalic, Jeff, Oliner, Jonathan D, Osgood, Tao, Peterson, Matthew L, Roveto, Philip, Saiki, Anne Y, Shaffer, Paul, Toteva, Maria, Wang, Yingcai, Wang, Yu Chung, Wortman, Sarah, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Yu, Ming, Zhao, Xiaoning, Zhou, Jing, Zhu, Jiang, Olson, Steven H, Medina, Julio C
Published in Journal of medicinal chemistry (27.02.2014)
Published in Journal of medicinal chemistry (27.02.2014)
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Structure-Based Design of Novel Inhibitors of the MDM2–p53 Interaction
Rew, Yosup, Sun, Daqing, Gonzalez-Lopez De Turiso, Felix, Bartberger, Michael D, Beck, Hilary P, Canon, Jude, Chen, Ada, Chow, David, Deignan, Jeffrey, Fox, Brian M, Gustin, Darin, Huang, Xin, Jiang, Min, Jiao, Xianyun, Jin, Lixia, Kayser, Frank, Kopecky, David J, Li, Yihong, Lo, Mei-Chu, Long, Alexander M, Michelsen, Klaus, Oliner, Jonathan D, Osgood, Tao, Ragains, Mark, Saiki, Anne Y, Schneider, Steve, Toteva, Maria, Yakowec, Peter, Yan, Xuelei, Ye, Qiuping, Yu, Dongyin, Zhao, Xiaoning, Zhou, Jing, Medina, Julio C, Olson, Steven H
Published in Journal of medicinal chemistry (14.06.2012)
Published in Journal of medicinal chemistry (14.06.2012)
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Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up
Wagner, Anna M., Bonderoff, Sara A., Chang, Stanley, Deignan, Jeffrey, Esanu, Michelle M., Van Huynh, Huy, Niu, Tianmin, Ngo, Vinh, O’Keefe, B. Michael, Phoenix, Jenny, Rainey, Trevor J., Roberts, Benjamin J., Shen, Jinyu, Stewart, Craig, Vandehey, Amanda L., Wolckenhauer, Scott A., Wong, Chloe Y., Yarmuch, Brian H.
Published in Organic process research & development (16.08.2024)
Published in Organic process research & development (16.08.2024)
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HAGGERTY KEVIN D, ELFORD TIMOTHY G, ELFGREN DANIELLE M, CHTELININE ANDREI, EBERLE KELLY J, NIU TIANMIN, CHAN LINA, DEIGNAN JEFFREY T, LI JESSE W, STEVENS ANDREW C, WILLIAMSON KEVIN S, XU BORAN, VOICA ANA F, ALLAN KEVIN M, DEMPAH KASSIBLA E, YU GUOJUN
Year of Publication 06.12.2022
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Year of Publication 06.12.2022
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 14.11.2023
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Year of Publication 14.11.2023
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Optimization beyond AMG 232: Discovery and SAR of sulfonamides on a piperidinone scaffold as potent inhibitors of the MDM2-p53 protein–protein interaction
Wang, Yingcai, Zhu, Jiang, Liu, Jiwen (Jim), Chen, Xiaoqi, Mihalic, Jeff, Deignan, Jeffrey, Yu, Ming, Sun, Daqing, Kayser, Frank, McGee, Lawrence R., Lo, Mei-Chu, Chen, Ada, Zhou, Jing, Ye, Qiuping, Huang, Xin, Long, Alexander M., Yakowec, Peter, Oliner, Jonathan D., Olson, Steven H., Medina, Julio C.
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
Published in Bioorganic & medicinal chemistry letters (15.08.2014)
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
EKSTEROWICZ JOHN, HUANG XIN, LIU JIWEN, FISHER BENJAMIN, FOX BRIAN MATTHEW, SUN DAQING, FU JIASHENG, JIAO XIANYUN, MCINTOSH JOEL, FU ZICE, OLSON STEVEN HOWARD, WANG XIAODONG, BECK HILARY PLAKE, GONZALEZ LOPEZ DE TURISO FELIX, LUCAS BRIAN STUART, LI YIHONG, ZHU JIANG, MCMINN DUSTIN, MIHALIC JEFFREY THOMAS, DUQUETTE JASON, MCGEE LAWRENCE, KAYSER FRANK, MA ZHIHUA, REW YOSUP, MEDINA JULIO CESAR, LAI SUJEN, GUSTIN DARIN JAMES, ROVETO PHILIP MARLEY, HEATH JULIE ANNE, CHEN XIAOQI, DEIGNAN JEFFREY, YAN XUELEI, JOHNSON MICHAEL, KOPECKY DAVID JOHN, LI ZHIHONG, GRIBBLE JR. MICHAEL WILLIAM, LOW JONATHAN DANTE, CONNORS RICHARD VICTOR, YU MING, BARTBERGER MICHAEL DAVID, WANG YINGCAI, GONZALEZ BUENROSTRO ANA
Year of Publication 20.06.2022
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Year of Publication 20.06.2022
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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Year of Publication 08.06.2021
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Year of Publication 08.06.2021
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Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists
Li, An-Rong, Johnson, Michael G., Liu, Jiwen, Chen, Xiaoqi, Du, Xiaohui, Mihalic, Jeffrey T., Deignan, Jeffrey, Gustin, Darin J., Duquette, Jason, Fu, Zice, Zhu, Liusheng, Marcus, Andrew P., Bergeron, Phillipe, McGee, Lawrence R., Danao, Jay, Lemon, Bryan, Carabeo, Teresa, Sullivan, Timothy, Ma, Ji, Tang, Liang, Tonn, George, Collins, Tassie L., Medina, Julio C.
Published in Bioorganic & medicinal chemistry (15.01.2008)
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Published in Bioorganic & medicinal chemistry (15.01.2008)
Published in Bioorganic & medicinal chemistry (15.01.2008)
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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Year of Publication 04.06.2020
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Year of Publication 04.06.2020
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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Year of Publication 29.05.2019
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Year of Publication 29.05.2019
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Year of Publication 04.06.2018
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Year of Publication 31.01.2018
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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Year of Publication 18.07.2014
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PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER
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Year of Publication 17.03.2014
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Year of Publication 27.08.2010
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Year of Publication 30.05.2024
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