An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ
Adolfsson, Oskar, Pihlgren, Maria, Toni, Nicolas, Varisco, Yvan, Buccarello, Anna Lucia, Antoniello, Katia, Lohmann, Sophie, Piorkowska, Kasia, Gafner, Valerie, Atwal, Jasvinder K, Maloney, Janice, Chen, Mark, Gogineni, Alvin, Weimer, Robby M, Mortensen, Deborah L, Friesenhahn, Michel, Ho, Carole, Paul, Robert, Pfeifer, Andrea, Muhs, Andreas, Watts, Ryan J
Published in The Journal of neuroscience (11.07.2012)
Published in The Journal of neuroscience (11.07.2012)
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Journal Article
Projecting human pharmacokinetics of therapeutic antibodies from nonclinical data: What have we learned?
Deng, Rong, Iyer, Suhasini, Theil, Frank-Peter, Mortensen, Deborah L., Fielder, Paul J., Prabhu, Saileta
Published in mAbs (01.01.2011)
Published in mAbs (01.01.2011)
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Journal Article
Dual mTORC1/mTORC2 Inhibition as a Host-Directed Therapeutic Target in Pathologically Distinct Mouse Models of Tuberculosis
Tasneen, Rokeya, Mortensen, Deborah S, Converse, Paul J, Urbanowski, Michael E, Upton, Anna, Fotouhi, Nader, Nuermberger, Eric, Hawryluk, Natalie
Published in Antimicrobial agents and chemotherapy (17.06.2021)
Published in Antimicrobial agents and chemotherapy (17.06.2021)
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Journal Article
CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro
Tsuji, Toshiya, Sapinoso, Lisa M, Tran, Tam, Gaffney, Bonny, Wong, Lilly, Sankar, Sabita, Raymon, Heather K, Mortensen, Deborah S, Xu, Shuichan
Published in Oncotarget (26.09.2017)
Published in Oncotarget (26.09.2017)
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Journal Article
Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation
Norris, Stephen, Ba, Xiaochu, Rhodes, Jayce, Huang, Dehua, Khambatta, Gody, Buenviaje, Jennifer, Nayak, Surendra, Meiring, Joseph, Reiss, Samantha, Xu, Shuichan, Shi, Lihong, Whitefield, Brandon, Alexander, Matt, Horn, Evan J., Correa, Matthew, Tehrani, Lida, Hansen, Joshua D., Papa, Patrick, Mortensen, Deborah S.
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Discovery of the c‑Jun N‑Terminal Kinase Inhibitor CC-90001
Nagy, Mark A, Hilgraf, Robert, Mortensen, Deborah S, Elsner, Jan, Norris, Stephen, Tikhe, Jayashree, Yoon, Won, Paisner, David, Delgado, Mercedes, Erdman, Paul, Haelewyn, Jason, Khambatta, Godrej, Xu, Li, Romanow, William J, Condroski, Kevin, Bahmanyar, Sogole, McCarrick, Meg, Benish, Brent, Blease, Kate, LeBrun, Laurie, Moghaddam, Mehran F, Apuy, Julius, Canan, Stacie S, Bennett, Brydon L, Satoh, Yoshitaka
Published in Journal of medicinal chemistry (23.12.2021)
Published in Journal of medicinal chemistry (23.12.2021)
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Journal Article
A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo
Atwal, Jasvinder K, Chen, Yongmei, Chiu, Cecilia, Mortensen, Deborah L, Meilandt, William J, Liu, Yichin, Heise, Christopher E, Hoyte, Kwame, Luk, Wilman, Lu, Yanmei, Peng, Kun, Wu, Ping, Rouge, Lionel, Zhang, Yingnan, Lazarus, Robert A, Scearce-Levie, Kimberly, Wang, Weiru, Wu, Yan, Tessier-Lavigne, Marc, Watts, Ryan J
Published in Science translational medicine (25.05.2011)
Published in Science translational medicine (25.05.2011)
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Journal Article
Correction to “Design and Synthesis of Novel Cereblon Binders for Use in Targeted Protein Degradation”
Norris, Stephen, Ba, Xiaochu, Rhodes, Jayce, Huang, Dehua, Khambatta, Gody, Buenviaje, Jennifer, Nayak, Surendra, Meiring, Joseph, Reiss, Samantha, Xu, Shuichan, Shi, Lihong, Whitefield, Brandon, Alexander, Matt, Horn, Evan J., Correa, Matthew, Tehrani, Lida, Hansen, Joshua D., Papa, Patrick, Mortensen, Deborah S., Brazeau, Jean-François
Published in Journal of medicinal chemistry (22.08.2024)
Published in Journal of medicinal chemistry (22.08.2024)
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Journal Article
Amyloid positron emission tomography and cerebrospinal fluid results from a crenezumab anti-amyloid-beta antibody double-blind, placebo-controlled, randomized phase II study in mild-to-moderate Alzheimer's disease (BLAZE)
Salloway, Stephen, Honigberg, Lee A, Cho, William, Ward, Michael, Friesenhahn, Michel, Brunstein, Flavia, Quartino, Angelica, Clayton, David, Mortensen, Deborah, Bittner, Tobias, Ho, Carole, Rabe, Christina, Schauer, Stephen P, Wildsmith, Kristin R, Fuji, Reina N, Suliman, Shehnaaz, Reiman, Eric M, Chen, Kewei, Paul, Robert
Published in Alzheimer's research & therapy (19.09.2018)
Published in Alzheimer's research & therapy (19.09.2018)
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Journal Article
A phase I dose‐escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC‐223 in patients with advanced solid tumors or multiple myeloma
Bendell, Johanna C., Kelley, Robin K., Shih, Kent C., Grabowsky, Jennifer A., Bergsland, Emily, Jones, Suzanne, Martin, Thomas, Infante, Jeffrey R., Mischel, Paul S., Matsutani, Tomoo, Xu, Shuichan, Wong, Lilly, Liu, Yong, Wu, Xiaoling, Mortensen, Deborah S., Chopra, Rajesh, Hege, Kristen, Munster, Pamela N.
Published in Cancer (01.10.2015)
Published in Cancer (01.10.2015)
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Journal Article
Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Shevlin, Graziella, Elsner, Jan, Zhao, Jingjing, Whitefield, Brandon, Tehrani, Lida, Sapienza, John, Riggs, Jennifer R., Parnes, Jason S., Papa, Patrick, Packard, Garrick, Lee, Branden G.S., Harris, Roy, Correa, Matthew, Bahmanyar, Sogole, Richardson, Samantha J., Peng, Sophie X., Leisten, Jim, Khambatta, Godrej, Hickman, Matt, Gamez, James C., Bisonette, René R., Apuy, Julius, Cathers, Brian E., Canan, Stacie S., Moghaddam, Mehran F., Raymon, Heather K., Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Journal Article
Discovery of the Selective Protein Kinase C-theta Kinase Inhibitor, CC-90005
Papa, Patrick, Whitefield, Brandon, Mortensen, Deborah S., Cashion, Dan, Huang, Dehua, Torres, Eduardo, Parnes, Jason, Sapienza, John, Hansen, Joshua, Correa, Matthew, Delgado, Mercedes, Harris, Roy, Hegde, Sayee, Norris, Stephen, Bahmanyar, Sogole, Plantevin-Krenitsky, Veronique, Liu, Zheng, Leftheris, Katerina, Kulkarni, Ashutosh, Bennett, Brydon, Hur, Eun Mi, Ringheim, Garth, Khambatta, Godrej, Chan, Henry, Muir, Jeffrey, Blease, Kate, Burnett, Kelven, LeBrun, Laurie, Morrison, Lisa, Celeridad, Maria, Khattri, Roli, Cathers, Brian E.
Published in Journal of medicinal chemistry (26.08.2021)
Published in Journal of medicinal chemistry (26.08.2021)
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Journal Article
SMG1, a nonsense‐mediated mRNA decay (NMD) regulator, as a candidate therapeutic target in multiple myeloma
Leeksma, Alexander C., Derks, Ingrid A. M., Garrick, Brett, Jongejan, Aldo, Colombo, Martino, Bloedjes, Timon, Trowe, Torsten, Leisten, Jim C., Howarth, Michelle, Malek, Mehnaz, Mortensen, Deborah S., Blease, Kate, Groza, Mathew C., Narla, Rama Krishna, Loos, Remco, Kersten, Marie‐José, Moerland, Perry D., Guikema, Jeroen E. J., Kater, Arnon P., Eldering, Eric, Filvaroff, Ellen H.
Published in Molecular oncology (01.02.2023)
Published in Molecular oncology (01.02.2023)
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Journal Article
CC-223, a Potent and Selective Inhibitor of mTOR Kinase: In Vitro and In Vivo Characterization
Mortensen, Deborah S, Fultz, Kimberly E, Xu, Shuichan, Xu, Weiming, Packard, Garrick, Khambatta, Godrej, Gamez, James C, Leisten, Jim, Zhao, Jingjing, Apuy, Julius, Ghoreishi, Kamran, Hickman, Matt, Narla, Rama Krishna, Bissonette, Rene, Richardson, Samantha, Peng, Sophie X, Perrin-Ninkovic, Sophie, Tran, Tam, Shi, Tao, Yang, Wen Qing, Tong, Zeen, Cathers, Brian E, Moghaddam, Mehran F, Canan, Stacie S, Worland, Peter, Sankar, Sabita, Raymon, Heather K
Published in Molecular cancer therapeutics (01.06.2015)
Published in Molecular cancer therapeutics (01.06.2015)
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Journal Article
The mTOR Kinase Inhibitors, CC214-1 and CC214-2, Preferentially Block the Growth of EGFRvIII-Activated Glioblastomas
GINI, Beatrice, ZANCA, Ciro, SHAOJUN ZHU, TANAKA, Kazuhiro, BABIC, Ivan, AKHAVAN, David, LIN, Kelly, ASSUNCAO, Alvaro, YUCHAO GU, BONETTI, Bruno, MORTENSEN, Deborah S, SHUICHAN XU, DELIANG GUO, RAYMON, Heather K, CAVENEE, Webster K, FURNARI, Frank B, JAMES, C. David, KROEMER, Guido, HEATH, James R, HEGE, Kristen, CHOPRA, Rajesh, CLOUGHESY, Timothy F, MISCHEL, Paul S, MATSUTANI, Tomoo, MASUI, Kenta, IKEGAMI, Shiro, HUIJUN YANG, NATHANSON, David, VILLA, Genaro R, SHACKELFORD, David
Published in Clinical cancer research (15.10.2013)
Published in Clinical cancer research (15.10.2013)
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Journal Article
Structure-based optimization of aminothiadiazole inhibitors of AKT
Mortensen, Deborah S., Hegde, Sayee G., Perrin-Ninkovic, Sophie M., Bahmanyar, Sogole, McCarrick, Meg, Harris, Roy, Hilgraf, Robert, Lee, Branden G. S., McKie, Jeff, Nadolny, Lisa, Sapienza, John, Collette, Alice, Cox, Sarah, Gamez, James C., Hensel, Jennifer L., Hua, Xuequn Helen, Leisten, Jim, Raymon, Heather K., Tran, Tam, Narla, Rama Krishna
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Journal Article
Discovery of Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor CC-223
Mortensen, Deborah S, Perrin-Ninkovic, Sophie M, Shevlin, Graziella, Zhao, Jingjing, Packard, Garrick, Bahmanyar, Sogole, Correa, Matthew, Elsner, Jan, Harris, Roy, Lee, Branden G. S, Papa, Patrick, Parnes, Jason S, Riggs, Jennifer R, Sapienza, John, Tehrani, Lida, Whitefield, Brandon, Apuy, Julius, Bisonette, René R, Gamez, James C, Hickman, Matt, Khambatta, Godrej, Leisten, Jim, Peng, Sophie X, Richardson, Samantha J, Cathers, Brian E, Canan, Stacie S, Moghaddam, Mehran F, Raymon, Heather K, Worland, Peter, Narla, Rama Krishna, Fultz, Kimberly E, Sankar, Sabita
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
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Journal Article
Use of core modification in the discovery of CC214-2, an orally available, selective inhibitor of mTOR kinase
Mortensen, Deborah S., Sapienza, John, Lee, Branden G.S., Perrin-Ninkovic, Sophie M., Harris, Roy, Shevlin, Graziella, Parnes, Jason S., Whitefield, Brandon, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Peng, Sophie, Gamez, Jim C., Leisten, Jim, Narla, Rama Krishna, Fultz, Kimberly E., Sankar, Sabita
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
Published in Bioorganic & medicinal chemistry letters (15.03.2013)
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Journal Article
Discovery and SAR exploration of a novel series of imidazo[4,5- b]pyrazin-2-ones as potent and selective mTOR kinase inhibitors
Mortensen, Deborah S., Perrin-Ninkovic, Sophie M., Harris, Roy, Lee, Branden G.S., Shevlin, Graziella, Hickman, Matt, Khambatta, Gody, Bisonette, Rene R., Fultz, Kimberly E., Sankar, Sabita
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
Published in Bioorganic & medicinal chemistry letters (15.11.2011)
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Journal Article
Genetic and pharmacologic evidence that mTOR targeting outweighs mTORC1 inhibition as an antimyeloma strategy
Chen, Xi, Díaz-Rodríguez, Elena, Ocio, Enrique M, Paiva, Bruno, Mortensen, Deborah S, Lopez-Girona, Antonia, Chopra, Rajesh, Miguel, Jesús San, Pandiella, Atanasio
Published in Molecular cancer therapeutics (01.02.2014)
Published in Molecular cancer therapeutics (01.02.2014)
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Journal Article