Arginine-selective modulation of the lysosomal transporter PQLC2 through a gate-tuning mechanism
Leray, Xavier, Conti, Rossella, Li, Yan, Debacker, Cécile, Castelli, Florence, Fenaille, François, Zdebik, Anselm A., Pusch, Michael, Gasnier, Bruno
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2021)
Published in Proceedings of the National Academy of Sciences - PNAS (10.08.2021)
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Amino Acids Bearing Aromatic or Heteroaromatic Substituents as a New Class of Ligands for the Lysosomal Sialic Acid Transporter Sialin
Dubois, Lilian, Pietrancosta, Nicolas, Cabaye, Alexandre, Fanget, Isabelle, Debacker, Cécile, Gilormini, Pierre-André, Dansette, Patrick M, Dairou, Julien, Biot, Christophe, Froissart, Roseline, Goupil-Lamy, Anne, Bertrand, Hugues-Olivier, Acher, Francine C, McCort-Tranchepain, Isabelle, Gasnier, Bruno, Anne, Christine
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy
Jézégou, Adrien, Llinares, Elisa, Anne, Christine, Kieffer-Jaquinod, Sylvie, O’Regan, Seana, Aupetit, Joëlle, Chabli, Allel, Sagné, Corinne, Debacker, Cécile, Chadefaux-Vekemans, Bernadette, Journet, Agnès, André, Bruno, Gasnier, Bruno
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2012)
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Journal Article
MFSD1 with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
Jungnickel, Katharina Esther Julia, Guelle, Océane, Iguchi, Miharu, Dong, Wentao, Kotov, Vadim, Gabriel, Florian, Debacker, Cécile, Dairou, Julien, McCort-Tranchepain, Isabelle, Laqtom, Nouf N., Chan, Sze Ham, Ejima, Akika, Sato, Kenji, Massa López, David, Saftig, Paul, Mehdipour, Ahmad Reza, Abu-Remaileh, Monther, Gasnier, Bruno, Löw, Christian, Damme, Markus
Published in Nature cell biology (01.07.2024)
Published in Nature cell biology (01.07.2024)
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Mechanism of proton/substrate coupling in the heptahelical lysosomal transporter cystinosin
Ruivo, Raquel, Bellenchi, Gian Carlo, Chen, Xiong, Zifarelli, Giovanni, Sagné, Corinne, Debacker, Cécile, Pusch, Michael, Supplisson, Stéphane, Gasnier, Bruno
Published in Proceedings of the National Academy of Sciences - PNAS (31.01.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (31.01.2012)
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Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L
Savalas, Lalu Rudyat Telly, Gasnier, Bruno, Damme, Markus, Lübke, Torben, Wrocklage, Christian, Debacker, Cécile, Jézégou, Adrien, Reinheckel, Thomas, Hasilik, Andrej, Saftig, Paul, Schröder, Bernd
Published in Biochemical journal (01.10.2011)
Published in Biochemical journal (01.10.2011)
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Journal Article
Successful Prediction of Substrate-binding Pocket in SLC17 Transporter Sialin
Pietrancosta, Nicolas, Anne, Christine, Prescher, Horst, Ruivo, Raquel, Sagné, Corinne, Debacker, Cécile, Bertrand, Hugues-Olivier, Brossmer, Reinhard, Acher, Francine, Gasnier, Bruno
Published in The Journal of biological chemistry (30.03.2012)
Published in The Journal of biological chemistry (30.03.2012)
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Journal Article
Molecular pathogenesis of sialic acid storage diseases: insight gained from four missense mutations and a putative polymorphism of human sialin
Ruivo, Raquel, Sharifi, Azita, Boubekeur, Samira, Morin, Pierre, Anne, Christine, Debacker, Cécile, Graziano, Jean-Charles, Sagné, Corinne, Gasnier, Bruno
Published in Biology of the cell (01.09.2008)
Published in Biology of the cell (01.09.2008)
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Journal Article
MFSD1 in complex with its accessory subunit GLMP functions as a general dipeptide uniporter in lysosomes
Katharina Esther Julia Jungnickel, Guelle, Oceane, Iguchi, Miharu, Dong, Wentao, Kotov, Vadim, Gabriel, Florian, Debacker, Cecile, Dairou, Julien, Mccort-Tranchepain, Isabelle, Laqtom, Nouf N, Sze Ham Chan, Ejima, Akika, Sato, Kenji, David Massa Lopez, Saftig, Paul, Mehdipour, Ahmad Reza, Abu-Remaileh, Monther, Gasnier, Bruno, Low, Christian, Damme, Markus
Published in bioRxiv (15.12.2023)
Published in bioRxiv (15.12.2023)
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Paper
Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy
Jézégou, Adrien, Llinares, Elisa, Anne, Christine, Kieffer-Jaquinod, Sylvie, O'Regan, Seana, Aupetit, Joëlle, Chabli, Allel, Sagné, Corinne, Debacker, Cécile, Chadefaux-Vekemans, Bernadette, Journet, Agnès, André, Bruno, Gasnier, Bruno
Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2012)
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Published in Proceedings of the National Academy of Sciences - PNAS (11.12.2012)
Journal Article
Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases
Kertesz, Nathalie, Samson, Jérôme, Debacker, Cécile, Wu, Hong, Labastie, Marie-Claude
Published in Gene (10.07.2002)
Published in Gene (10.07.2002)
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Melanotransferrin gene expression in melanoma cells is correlated with high levels of Jun/Fos family transcripts and with the presence of a specific AP1-dependent ternary complex
Rozé-Heusse, A, Houbiguian, M L, Debacker, C, Zakin, M M, Duchange, N
Published in Biochemical journal (15.09.1996)
Published in Biochemical journal (15.09.1996)
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