Efficacy of DYRK1A inhibitors in novel models of Down syndrome acute lymphoblastic leukemia
Carey-Smith, Shannon L, Simad, Maryam H, Panchal, Kunjal, Aya-Bonilla, Carlos, Smolders, Hannah, Lin, Sang, Armitage, Jesse D, Nguyen, Vivien T, Bentley, Kathryn, Ford, Jette, Singh, Sajla, Oommen, Joyce, Laurent, Anouchka P, Mercher, Thomas, Crispino, John D, Montgomery, Andrew P, Kassiou, Michael, Besson, Thierry, Deau, Emmanuel, Meijer, Laurent, Cheung, Laurence C, Kotecha, Rishi S, Malinge, Sébastien
Published in Haematologica (Roma) (01.07.2024)
Published in Haematologica (Roma) (01.07.2024)
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Rational Design, Pharmacomodulation, and Synthesis of Dual 5‑Hydroxytryptamine 7 (5-HT7)/5-Hydroxytryptamine 2A (5-HT2A) Receptor Antagonists and Evaluation by [18F]-PET Imaging in a Primate Brain
Deau, Emmanuel, Robin, Elodie, Voinea, Raluca, Percina, Nathalie, Satała, Grzegorz, Finaru, Adriana-Luminita, Chartier, Agnès, Tamagnan, Gilles, Alagille, David, Bojarski, Andrzej J, Morisset-Lopez, Séverine, Suzenet, Franck, Guillaumet, Gérald
Published in Journal of medicinal chemistry (22.10.2015)
Published in Journal of medicinal chemistry (22.10.2015)
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Journal Article
Microwave-assisted kinetic resolution of homochiral (Z)-cyclooct-5-ene-1,2-diol and (Z)-2-acetoxycyclooct-4-enyl acetate using lipases
Rouillard, Hervé, Deau, Emmanuel, Domon, Lisianne, Chérouvrier, Jean-René, Graber, Marianne, Thiéry, Valérie
Published in Molecules (Basel, Switzerland) (02.07.2014)
Published in Molecules (Basel, Switzerland) (02.07.2014)
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Journal Article
Comparative Efficacy and Selectivity of Pharmacological Inhibitors of DYRK and CLK Protein Kinases
Lindberg, Mattias F., Deau, Emmanuel, Arfwedson, Jonas, George, Nicolas, George, Pascal, Alfonso, Patricia, Corrionero, Ana, Meijer, Laurent
Published in Journal of medicinal chemistry (23.03.2023)
Published in Journal of medicinal chemistry (23.03.2023)
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Journal Article
HIGHLIGTHS IN 1,2,3-DITHIAZOLE CHEMISTRY
Valérie Thiéry, Lisianne Domon, Jean-René Chérouvrier, Philippe Pineau, Emmanuel Deau, Hervé Rouillard, Hélène Laborie
Published in Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry (01.04.2010)
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Published in Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry (01.04.2010)
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Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B
Deau, Emmanuel, Lindberg, Mattias F., Miege, Frédéric, Roche, Didier, George, Nicolas, George, Pascal, Krämer, Andreas, Knapp, Stefan, Meijer, Laurent
Published in Journal of medicinal chemistry (10.08.2023)
Published in Journal of medicinal chemistry (10.08.2023)
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Microwave-assisted synthesis of novel N-(4-phenylthiazol-2-yl)-benzo[d]thiazole-, thiazolo[4,5-b]pyridine-, thiazolo[5,4-b]pyridine- and benzo[d]oxazole-2-carboximidamides inspired by marine topsentines and nortopsentines
Deau, Emmanuel, Dubouilh-Benard, Carole, Levacher, Vincent, Besson, Thierry
Published in Tetrahedron (02.09.2014)
Published in Tetrahedron (02.09.2014)
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Journal Article
Serodolin, a β-arrestin-biased ligand of 5-HT 7 receptor, attenuates pain-related behaviors
El Khamlichi, Chayma, Reverchon, Flora, Hervouet-Coste, Nadège, Robin, Elodie, Chopin, Nicolas, Deau, Emmanuel, Madouri, Fahima, Guimpied, Cyril, Colas, Cyril, Menuet, Arnaud, Inoue, Asuka, Bojarski, Andrzej J, Guillaumet, Gérald, Suzenet, Franck, Reiter, Eric, Morisset-Lopez, Séverine
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2022)
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Convenient one-pot synthesis of N-3-substituted pyrido[2,3-d]-, pyrido[3,4-d]-, pyrido[4,3-d]-pyrimidin-4(3H)-ones, and quinazolin-4(3H)-ones analogs
Deau, Emmanuel, Hedou, Damien, Chosson, Elizabeth, Levacher, Vincent, Besson, Thierry
Published in Tetrahedron letters (03.07.2013)
Published in Tetrahedron letters (03.07.2013)
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Journal Article
Serodolin, a β-arrestin–biased ligand of 5-HT7 receptor, attenuates pain-related behaviors
El Khamlichi, Chayma, Reverchon, Flora, Hervouet-Coste, Nadège, Robin, Elodie, Chopin, Nicolas, Deau, Emmanuel, Madouri, Fahima, Guimpied, Cyril, Colas, Cyril, Menuet, Arnaud, Inoue, Asuka, Bojarski, Andrzej J, Guillaumet, Gérald, Suzenet, Franck, Reiter, Eric, Morisset-Lopez, Séverine
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2022)
Published in Proceedings of the National Academy of Sciences - PNAS (24.05.2022)
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Journal Article
Organocatalytic enantioselective synthesis of β-amino sulfonic acid derivatives
Deau, Emmanuel, Le Foll, Alexandra, Fouache, Clémence, Corrot, Emilie, Bailly, Laetitia, Levacher, Vincent, Marchand, Pierric, Querniard, Florian, Bischoff, Laurent, Brière, Jean-François
Published in Chemical communications (Cambridge, England) (28.08.2021)
Published in Chemical communications (Cambridge, England) (28.08.2021)
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Journal Article
Chemical, Biochemical, Cellular, and Physiological Characterization of Leucettinib-21, a Down Syndrome and Alzheimer’s Disease Drug Candidate
Lindberg, Mattias F., Deau, Emmanuel, Miege, Frédéric, Greverie, Marie, Roche, Didier, George, Nicolas, George, Pascal, Merlet, Laura, Gavard, Julie, Brugman, Sander J. T., Aret, Edwin, Tinnemans, Paul, de Gelder, René, Sadownik, Jan, Verhofstad, Eva, Sleegers, Dennis, Santangelo, Sara, Dairou, Julien, Fernandez-Blanco, Álvaro, Dierssen, Mara, Krämer, Andreas, Knapp, Stefan, Meijer, Laurent
Published in Journal of medicinal chemistry (14.12.2023)
Published in Journal of medicinal chemistry (14.12.2023)
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Journal Article
Structure–Activity Relationship in the Leucettine Family of Kinase Inhibitors
Tahtouh, Tania, Durieu, Emilie, Villiers, Benoît, Bruyère, Céline, Nguyen, Thu Lan, Fant, Xavier, Ahn, Kwang H, Khurana, Leepakshi, Deau, Emmanuel, Lindberg, Mattias F, Sévère, Elodie, Miege, Frédéric, Roche, Didier, Limanton, Emmanuelle, L’Helgoual’ch, Jean-Martial, Burgy, Guillaume, Guiheneuf, Solène, Herault, Yann, Kendall, Debra A, Carreaux, François, Bazureau, Jean-Pierre, Meijer, Laurent
Published in Journal of medicinal chemistry (27.01.2022)
Published in Journal of medicinal chemistry (27.01.2022)
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Journal Article
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome
Lana-Elola, Eva, Aoidi, Rifdat, Llorian, Miriam, Gibbins, Dorota, Buechsenschuetz, Callan, Bussi, Claudio, Flynn, Helen, Gilmore, Tegan, Watson-Scales, Sheona, Haugsten Hansen, Marie, Hayward, Darryl, Song, Ok-Ryul, Brault, Véronique, Herault, Yann, Deau, Emmanuel, Meijer, Laurent, Snijders, Ambrosius P, Gutierrez, Maximiliano G, Fisher, Elizabeth M C, Tybulewicz, Victor L J
Published in Science translational medicine (24.01.2024)
Published in Science translational medicine (24.01.2024)
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Synthesis and molecular modelling studies of 8-arylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amines as multitarget Ser/Thr kinases inhibitors
Loidreau, Yvonnick, Deau, Emmanuel, Marchand, Pascal, Nourrisson, Marie-Renée, Logé, Cédric, Coadou, Gaël, Loaëc, Nadège, Meijer, Laurent, Besson, Thierry
Published in European journal of medicinal chemistry (06.03.2015)
Published in European journal of medicinal chemistry (06.03.2015)
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Journal Article
A Meldrum's Acid Based Multicomponent Synthesis of N-Fmoc-isoxazolidin-5-ones: Entry to N-Fmoc-[beta]-amino Acids
Le Foll Devaux, Alexandra, Deau, Emmanuel, Corrot, Emilie, Bischoff, Laurent, Levacher, Vincent, Briere, Jean-François
Published in European journal of organic chemistry (01.06.2017)
Published in European journal of organic chemistry (01.06.2017)
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Journal Article
A Meldrum's Acid Based Multicomponent Synthesis of N‐Fmoc‐isoxazolidin‐5‐ones: Entry to N‐Fmoc‐β‐amino Acids
Le Foll Devaux, Alexandra, Deau, Emmanuel, Corrot, Emilie, Bischoff, Laurent, Levacher, Vincent, Brière, Jean‐François
Published in European journal of organic chemistry (16.06.2017)
Published in European journal of organic chemistry (16.06.2017)
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