A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
Cook, Peter C., Owen, Heather, Deaton, Aimée M., Borger, Jessica G., Brown, Sheila L., Clouaire, Thomas, Jones, Gareth-Rhys, Jones, Lucy H., Lundie, Rachel J., Marley, Angela K., Morrison, Vicky L., Phythian-Adams, Alexander T., Wachter, Elisabeth, Webb, Lauren M., Sutherland, Tara E., Thomas, Graham D., Grainger, John R., Selfridge, Jim, McKenzie, Andrew N. J., Allen, Judith E., Fagerholm, Susanna C., Maizels, Rick M., Ivens, Alasdair C., Bird, Adrian, MacDonald, Andrew S.
Published in Nature communications (24.04.2015)
Published in Nature communications (24.04.2015)
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Cell type-specific DNA methylation at intragenic CpG islands in the immune system
Deaton, Aimée M, Webb, Shaun, Kerr, Alastair R W, Illingworth, Robert S, Guy, Jacky, Andrews, Robert, Bird, Adrian
Published in Genome research (01.07.2011)
Published in Genome research (01.07.2011)
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Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects
Nguyen, Phuong A., Born, David A., Deaton, Aimee M., Nioi, Paul, Ward, Lucas D.
Published in Nature communications (05.04.2019)
Published in Nature communications (05.04.2019)
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MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
Mieczkowski, Jakub, Cook, April, Bowman, Sarah K., Mueller, Britta, Alver, Burak H., Kundu, Sharmistha, Deaton, Aimee M., Urban, Jennifer A., Larschan, Erica, Park, Peter J., Kingston, Robert E., Tolstorukov, Michael Y.
Published in Nature communications (06.05.2016)
Published in Nature communications (06.05.2016)
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Genome-wide association meta-analysis yields 20 loci associated with gallstone disease
Ferkingstad, Egil, Oddsson, Asmundur, Gretarsdottir, Solveig, Benonisdottir, Stefania, Thorleifsson, Gudmar, Deaton, Aimee M., Jonsson, Stefan, Stefansson, Olafur A., Norddahl, Gudmundur L., Zink, Florian, Arnadottir, Gudny A., Gunnarsson, Bjarni, Halldorsson, Gisli H., Helgadottir, Anna, Jensson, Brynjar O., Kristjansson, Ragnar P., Sveinbjornsson, Gardar, Sverrisson, David A., Masson, Gisli, Olafsson, Isleifur, Eyjolfsson, Gudmundur I., Sigurdardottir, Olof, Holm, Hilma, Jonsdottir, Ingileif, Olafsson, Sigurdur, Steingrimsdottir, Thora, Rafnar, Thorunn, Bjornsson, Einar S., Thorsteinsdottir, Unnur, Gudbjartsson, Daniel F., Sulem, Patrick, Stefansson, Kari
Published in Nature communications (30.11.2018)
Published in Nature communications (30.11.2018)
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Rare loss of function variants in the hepatokine gene INHBE protect from abdominal obesity
Deaton, Aimee M., Dubey, Aditi, Ward, Lucas D., Dornbos, Peter, Flannick, Jason, Yee, Elaine, Ticau, Simina, Noetzli, Leila, Parker, Margaret M., Hoffing, Rachel A., Willis, Carissa, Plekan, Mollie E., Holleman, Aaron M., Hinkle, Gregory, Fitzgerald, Kevin, Vaishnaw, Akshay K., Nioi, Paul
Published in Nature communications (27.07.2022)
Published in Nature communications (27.07.2022)
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Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming
West, Jason A., Cook, April, Alver, Burak H., Stadtfeld, Matthias, Deaton, Aimee M., Hochedlinger, Konrad, Park, Peter J., Tolstorukov, Michael Y., Kingston, Robert E.
Published in Nature communications (27.08.2014)
Published in Nature communications (27.08.2014)
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H3K27 modifications define segmental regulatory domains in the Drosophila bithorax complex
Bowman, Sarah K, Deaton, Aimee M, Domingues, Heber, Wang, Peggy I, Sadreyev, Ruslan I, Kingston, Robert E, Bender, Welcome
Published in eLife (31.07.2014)
Published in eLife (31.07.2014)
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A unique DNA methylation signature defines a population of IFN‐γ/IL‐4 double‐positive T cells during helminth infection
Deaton, Aimée M., Cook, Peter C., De Sousa, Dina, Phythian‐Adams, Alexander T., Bird, Adrian, MacDonald, Andrew S.
Published in European journal of immunology (01.06.2014)
Published in European journal of immunology (01.06.2014)
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Enhancer regions show high histone H3.3 turnover that changes during differentiation
Deaton, Aimee M, Gómez-Rodríguez, Mariluz, Mieczkowski, Jakub, Tolstorukov, Michael Y, Kundu, Sharmistha, Sadreyev, Ruslan I, Jansen, Lars Et, Kingston, Robert E
Published in eLife (15.06.2016)
Published in eLife (15.06.2016)
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Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry
Parker, Margaret M., Damrauer, Scott M., Tcheandjieu, Catherine, Erbe, David, Aldinc, Emre, Hawkins, Philip N., Gillmore, Julian D., Hull, Leland E., Lynch, Julie A., Joseph, Jacob, Ticau, Simina, Flynn-Carroll, Alexander O., Deaton, Aimee M., Ward, Lucas D., Assimes, Themistocles L., Tsao, Philip S., Chang, Kyong-Mi, Rader, Daniel J., Fitzgerald, Kevin, Vaishnaw, Akshay K., Hinkle, Gregory, Nioi, Paul
Published in Scientific reports (02.06.2021)
Published in Scientific reports (02.06.2021)
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A unique DNA methylation signature defines a population of IFN-[gamma]/IL-4 double-positive T cells during helminth infection
Deaton, Aimée M, Cook, Peter C, De Sousa, Dina, Phythian-Adams, Alexander T, Bird, Adrian, MacDonald, Andrew S
Published in European journal of immunology (01.06.2014)
Published in European journal of immunology (01.06.2014)
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Using human genetics to improve safety assessment of therapeutics
Carss, Keren J., Deaton, Aimee M., Del Rio-Espinola, Alberto, Diogo, Dorothée, Fielden, Mark, Kulkarni, Diptee A., Moggs, Jonathan, Newham, Peter, Nelson, Matthew R., Sistare, Frank D., Ward, Lucas D., Yuan, Jing
Published in Nature reviews. Drug discovery (01.02.2023)
Published in Nature reviews. Drug discovery (01.02.2023)
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Activin E is a transforming growth factor β ligand that signals specifically through activin receptor-like kinase 7
Vestal, Kylie A, Kattamuri, Chandramohan, Koyiloth, Muhasin, Ongaro, Luisina, Howard, James A, Deaton, Aimee M, Ticau, Simina, Dubey, Aditi, Bernard, Daniel J, Thompson, Thomas B
Published in Biochemical journal (10.04.2024)
Published in Biochemical journal (10.04.2024)
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Rationalizing Secondary Pharmacology Screening Using Human Genetic and Pharmacological Evidence
Deaton, Aimee M, Fan, Fan, Zhang, Wei, Nguyen, Phuong A, Ward, Lucas D, Nioi, Paul
Published in Toxicological sciences (01.02.2019)
Published in Toxicological sciences (01.02.2019)
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Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture
Turk, James R., Deaton, Aimee M., Yin, Jun, Stolina, Marina, Felx, Melanie, Boyd, Gabrielle, Bienvenu, Jean-Guy, Varela, Aurore, Guillot, Martin, Holdsworth, Gill, Wolfreys, Alison, Dwyer, Denise, Kumar, Sheetal V., de Koning, Emily M., Qu, Yusheng, Engwall, Michael, Locher, Kathrin, Ward, Lucas D., Glaus, Charles, He, Yudong D., Boyce, Rogely Waite
Published in Regulatory toxicology and pharmacology (01.08.2020)
Published in Regulatory toxicology and pharmacology (01.08.2020)
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