Dolutegravir (S/GSK1349572) Exhibits Significantly Slower Dissociation than Raltegravir and Elvitegravir from Wild-Type and Integrase Inhibitor-Resistant HIV-1 Integrase-DNA Complexes
HIGHTOWER, Kendra E, WANG, Ruolan, SEKI, Takahiro, KOBAYASHI, Masanori, UNDERWOOD, Mark R, DEANDA, Felix, JOHNS, Brian A, WEAVER, Kurt, YINGNIAN SHEN, TOMBERLIN, Ginger H, LUKE CARTER, H, BRODERICK, Timothy, SIGETHY, Scott
Published in Antimicrobial Agents and Chemotherapy (01.10.2011)
Published in Antimicrobial Agents and Chemotherapy (01.10.2011)
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Journal Article
Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics
DeAnda, Felix, Hightower, Kendra E, Nolte, Robert T, Hattori, Kazunari, Yoshinaga, Tomokazu, Kawasuji, Takashi, Underwood, Mark R
Published in PloS one (16.10.2013)
Published in PloS one (16.10.2013)
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Prevalent Polymorphisms in Wild-Type HIV-1 Integrase Are Unlikely To Engender Drug Resistance to Dolutegravir (S/GSK1349572)
Vavro, Cindy, Hasan, Samiul, Madsen, Heather, Horton, Joseph, DeAnda, Felix, Martin-Carpenter, Louise, Sato, Akihiko, Cuffe, Robert, Chen, Shuguang, Underwood, Mark, Nichols, Garrett
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
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Journal Article
Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity
Chamberlain, Stanley D, Redman, Anikó M, Wilson, Joseph W, Deanda, Felix, Shotwell, J Brad, Gerding, Roseanne, Lei, Huangshu, Yang, Bin, Stevens, Kirk L, Hassell, Anne M, Shewchuk, Lisa M, Leesnitzer, M Anthony, Smith, Jeffery L, Sabbatini, Peter, Atkins, Charity, Groy, Arthur, Rowand, Jason L, Kumar, Rakesh, Mook, Jr, Robert A, Moorthy, Ganesh, Patnaik, Samarjit
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Journal Article
Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
Li, Wei, Sano, Renata, Apatira, Mutiah, DeAnda, Felix, Gururaja, Tarikere, Yang, Muhua, Lundgaard, Greta, Pan, Chin, Liu, Jing, Zhai, Yongjiao, Yoon, Woo Hyun, Wang, Longcheng, Tse, Chris, Souers, Andrew J, Lee, Chih-Hung
Published in Molecular cancer therapeutics (03.01.2024)
Published in Molecular cancer therapeutics (03.01.2024)
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Journal Article
Inhibition of the Ribonuclease H Activity of HIV-1 Reverse Transcriptase by GSK5750 Correlates with Slow Enzyme-Inhibitor Dissociation
Beilhartz, Greg L., Ngure, Marianne, Johns, Brian A., DeAnda, Felix, Gerondelis, Peter, Götte, Matthias
Published in The Journal of biological chemistry (06.06.2014)
Published in The Journal of biological chemistry (06.06.2014)
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Journal Article
Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats
Duan, Maosheng, Kazmierski, Wieslaw M., Chong, Pek Y., DeAnda, Felix, Edelstein, Mark, Ferris, Rob, Peckham, Jennifer, Wheelan, Pat, Xiong, Zhiping, Zhang, Huichang, Nishizawa, Rena, Takaoka, Yoshikazu
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
Published in Bioorganic & medicinal chemistry letters (01.11.2011)
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Discovery of Bioavailable 4,4-Disubstituted Piperidines as Potent Ligands of the Chemokine Receptor 5 and Inhibitors of the Human Immunodeficiency Virus-1
Kazmierski, Wieslaw M, Aquino, Christopher, Chauder, Brian A, Deanda, Felix, Ferris, Robert, Jones-Hertzog, Deborah K, Kenakin, Terrence, Koble, Cecilia S, Watson, Christian, Wheelan, Pat, Yang, Hanbiao, Youngman, Michael
Published in Journal of medicinal chemistry (23.10.2008)
Published in Journal of medicinal chemistry (23.10.2008)
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Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase
Patnaik, Samarjit, Stevens, Kirk L., Gerding, Roseanne, Deanda, Felix, Shotwell, J. Brad, Tang, Jun, Hamajima, Toshihiro, Nakamura, Hiroko, Leesnitzer, M. Anthony, Hassell, Anne M., Shewchuck, Lisa M., Kumar, Rakesh, Lei, Huangshu, Chamberlain, Stanley D.
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
Published in Bioorganic & medicinal chemistry letters (01.06.2009)
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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines : Potent inhibitors of the IGF-1R receptor tyrosine kinase
CHAMBERLAIN, Stanley D, WILSON, Joseph W, ATKINS, Charity, GERDING, Roseanne, HASSELL, Anne M, HUANGSHU LEI, MOCK, Robert A, MOORTHY, Ganesh, ROWAND, Jason L, STEVENS, Kirk L, KUMAR, Rakesh, BRAD SHOTWELL, J, DEANDA, Felix, PATNAIK, Samarjit, REDMAN, Aniko M, BIN YANG, SHEWCHUK, Lisa, SABBATINI, Peter, LEESNITZER, M. Anthony, GROY, Arthur
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Journal Article
Aza-stilbenes as potent and selective c-RAF inhibitors
McDonald, Octerloney, Lackey, Karen, Davis-Ward, Ronda, Wood, Edgar, Samano, Vicente, Maloney, Patrick, Deanda, Felix, Hunter, Robert
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
Published in Bioorganic & medicinal chemistry letters (15.10.2006)
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Journal Article
Optimization of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine inhibitors of IGF-1R : Elimination of an acid-mediated decomposition pathway
CHAMBERLAIN, Stanley D, REDMAN, Aniko M, STEVENS, Kirk L, WILSON, Joseph W, BRAD SHOTWELL, J, PATNAIK, Samarjit, BRICKHOUSE, Keith, CHEW, Yen-Chiat, DEANDA, Felix, GERDING, Roseanne, HUANGSHU LEI, MOORTHY, Ganesh, PATRICK, Mark
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
Published in Bioorganic & medicinal chemistry letters (15.01.2009)
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Journal Article
Dolutegravir Interactions with HIV-1 Integrase-DNA: Structural Rationale for Drug Resistance and Dissociation Kinetics: e77448
DeAnda, Felix, Hightower, Kendra E, Nolte, Robert T, Hattori, Kazunari, Yoshinaga, Tomokazu, Kawasuji, Takashi, Underwood, Mark R
Published in PloS one (01.10.2013)
Published in PloS one (01.10.2013)
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Journal Article
GSSI, a General Model for Solute−Solvent Interactions. 1. Description of the Model
Deanda, Felix, Smith, Karl M, Liu, Jie, Pearlman, Robert S
Published in Molecular pharmaceutics (12.01.2004)
Published in Molecular pharmaceutics (12.01.2004)
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Journal Article
Application of the PharmPrint Methodology to Two Protein Kinases
Deanda, Felix, Stewart, Eugene L
Published in Journal of Chemical Information and Computer Sciences (01.09.2004)
Published in Journal of Chemical Information and Computer Sciences (01.09.2004)
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Journal Article
Optimization of a series of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine inhibitors of IGF-1R: Elimination of an acid-mediated decomposition pathway
Chamberlain, Stanley D., Redman, Anikó M., Patnaik, Samarjit, Brickhouse, Keith, Chew, Yen-Chiat, Deanda, Felix, Gerding, Roseanne, Lei, Huangshu, Moorthy, Ganesh, Patrick, Mark, Stevens, Kirk L., Wilson, Joseph W., Brad Shotwell, J.
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article
Discovery of 3,5-disubstituted-lH-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase
PATNAIK, Samarjit, STEVENS, Kirk L, SHEWCHUCK, Lisa M, KUMAR, Rakesh, HUANGSHU LEI, CHAMBERLAIN, Stanley D, GERDING, Roseanne, DEANDA, Felix, BRAD SHOTWELL, J, JUN TANG, HAMAJIMA, Toshihiro, NAKAMURA, Hiroko, LEESNITZER, M. Anthony, HASSELL, Anne M
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
Journal Article
Optimization of 4,6-bis-anilino-1 H-pyrrolo[2,3- d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity
Chamberlain, Stanley D., Redman, Anikó M., Wilson, Joseph W., Deanda, Felix, Shotwell, J. Brad, Gerding, Roseanne, Lei, Huangshu, Yang, Bin, Stevens, Kirk L., Hassell, Anne M., Shewchuk, Lisa M., Leesnitzer, M. Anthony, Smith, Jeffery L., Sabbatini, Peter, Atkins, Charity, Groy, Arthur, Rowand, Jason L., Kumar, Rakesh, Mook, Robert A., Moorthy, Ganesh, Patnaik, Samarjit
Published in Bioorganic & medicinal chemistry letters (2009)
Published in Bioorganic & medicinal chemistry letters (2009)
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Journal Article