Selective Tumor Necrosis Factor Receptor I Blockade Is Antiinflammatory and Reveals Immunoregulatory Role of Tumor Necrosis Factor Receptor II in Collagen‐Induced Arthritis
McCann, Fiona E., Perocheau, Dany P., Ruspi, Gerhard, Blazek, Katrina, Davies, Marie L., Feldmann, Marc, Dean, Jonathan L. E., Stoop, A. Allart, Williams, Richard O.
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2014)
Published in Arthritis & rheumatology (Hoboken, N.J.) (01.10.2014)
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Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin
Ross, Ewan A, Smallie, Tim, Ding, Qize, O'Neil, John D, Cunliffe, Helen E, Tang, Tina, Rosner, Dalya R, Klevernic, Iva, Morrice, Nicholas A, Monaco, Claudia, Cunningham, Adam F, Buckley, Christopher D, Saklatvala, Jeremy, Dean, Jonathan L, Clark, Andrew R
Published in The Journal of immunology (1950) (01.07.2015)
Published in The Journal of immunology (1950) (01.07.2015)
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Heat shock protein B1-deficient mice display impaired wound healing
Crowe, Jonathan, Aubareda, Anna, McNamee, Kay, Przybycien, Paulina M, Lu, Xin, Williams, Richard O, Bou-Gharios, George, Saklatvala, Jeremy, Dean, Jonathan L E
Published in PloS one (15.10.2013)
Published in PloS one (15.10.2013)
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Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation
Brook, Matthew, Tomlinson, Gareth H., Miles, Katherine, Smith, Richard W. P., Rossi, Adriano G., Hiemstra, Pieter S., van ’t Wout, Emily F. A., Dean, Jonathan L. E., Gray, Nicola K., Lu, Wuyuan, Gray, Mohini
Published in Proceedings of the National Academy of Sciences - PNAS (19.04.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (19.04.2016)
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Journal Article
MAPKAP Kinase 2 Blocks Tristetraprolin-directed mRNA Decay by Inhibiting CAF1 Deadenylase Recruitment
Marchese, Francesco P., Aubareda, Anna, Tudor, Corina, Saklatvala, Jeremy, Clark, Andrew R., Dean, Jonathan L.E.
Published in The Journal of biological chemistry (03.09.2010)
Published in The Journal of biological chemistry (03.09.2010)
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Cross Talk between the Akt and p38α Pathways in Macrophages Downstream of Toll-Like Receptor Signaling
McGuire, Victoria A., Gray, Alexander, Monk, Claire E., Santos, Susana G., Lee, Keunwook, Aubareda, Anna, Crowe, Jonathan, Ronkina, Natalia, Schwermann, Jessica, Batty, Ian H., Leslie, Nick R., Dean, Jonathan L. E., O'Keefe, Stephen J., Boothby, Mark, Gaestel, Matthias, Arthur, J. Simon C.
Published in Molecular and Cellular Biology (01.11.2013)
Published in Molecular and Cellular Biology (01.11.2013)
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Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-β-activated Kinase-1 (TAK1)-mediated Signaling
Alford, Kate A., Glennie, Sarah, Turrell, Bryony R., Rawlinson, Lesley, Saklatvala, Jeremy, Dean, Jonathan L.E.
Published in The Journal of biological chemistry (02.03.2007)
Published in The Journal of biological chemistry (02.03.2007)
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MSK1 and MSK2 Inhibit Lipopolysaccharide-Induced Prostaglandin Production via an Interleukin-10 Feedback Loop
MacKenzie, Kirsty F., Van Den Bosch, Mirjam W. M., Naqvi, Shaista, Elcombe, Suzanne E., McGuire, Victoria A., Reith, Alastair D., Blackshear, Perry J., Dean, Jonathan L. E., Arthur, J. Simon C.
Published in Molecular and Cellular Biology (01.04.2013)
Published in Molecular and Cellular Biology (01.04.2013)
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Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide
Smallie, Tim, Ross, Ewan A, Ammit, Alaina J, Cunliffe, Helen E, Tang, Tina, Rosner, Dalya R, Ridley, Michael L, Buckley, Christopher D, Saklatvala, Jeremy, Dean, Jonathan L, Clark, Andrew R
Published in The Journal of immunology (1950) (01.07.2015)
Published in The Journal of immunology (1950) (01.07.2015)
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Journal Article
HSP25 Vaccination Attenuates Atherogenesis via Upregulation of LDLR Expression, Lowering of PCSK9 Levels and Curbing of Inflammation
Chen, Yong-Xiang, Shi, Chunhua, Deng, Jingti, Diao, Catherine, Maarouf, Nadia, Rosin, Matthew, Shrivastava, Vipul, Hu, Angie A, Bharadwa, Sonya, Adijiang, Ayinuer, Ulke-Lemee, Annegret, Gwilym, Brenig, Hellmich, Alexandria, Malozzi, Christopher, Batulan, Zarah, Dean, Jonathan L E, Ramirez, F Daniel, Liu, Jingwen, Gerthoffer, William T, O'Brien, Edward R
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2021)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.06.2021)
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PARP-14 combines with tristetraprolin in the selective posttranscriptional control of macrophage tissue factor expression
Iqbal, M. Bilal, Johns, Michael, Cao, Jun, Liu, Yu, Yu, Sheng-Chun, Hyde, Gareth D., Laffan, Michael A., Marchese, Francesco P., Cho, Sung Hoon, Clark, Andrew R., Gavins, Felicity N., Woollard, Kevin J., Blackshear, Perry J., Mackman, Nigel, Dean, Jonathan L., Boothby, Mark, Haskard, Dorian O.
Published in Blood (04.12.2014)
Published in Blood (04.12.2014)
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Journal Article
Heat shock protein‐27 and sex‐selective regulation of muscarinic and proteinase‐activated receptor 2‐mediated vasodilatation: differential sensitivity to endothelial NOS inhibition
Pulakazhi Venu, Vivek Krishna, Saifeddine, Mahmoud, Mihara, Koichiro, El‐Daly, Mahmoud, Belke, Darrell, Dean, Jonathan L E, O'Brien, Edward R, Hirota, Simon A, Hollenberg, Morley D
Published in British journal of pharmacology (01.06.2018)
Published in British journal of pharmacology (01.06.2018)
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Cezanne Regulates Inflammatory Responses to Hypoxia in Endothelial Cells by Targeting TRAF6 for Deubiquitination
Luong, Le A, Fragiadaki, Maria, Smith, Jennifer, Boyle, Joseph, Lutz, Jens, Dean, Jonathan L.E, Harten, Sarah, Ashcroft, Margaret, Walmsley, Sarah R, Haskard, Dorian O, Maxwell, Patrick H, Walczak, Henning, Pusey, Charles, Evans, Paul C
Published in Circulation research (07.06.2013)
Published in Circulation research (07.06.2013)
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Gain-of-Function Mutation of Tristetraprolin Impairs Negative Feedback Control of Macrophages In Vitro yet Has Overwhelmingly Anti-Inflammatory Consequences In Vivo
O'Neil, John D., Ross, Ewan A., Ridley, Michael L., Ding, Qize, Tang, Tina, Rosner, Dalya R., Crowley, Thomas, Malhi, Deepak, Dean, Jonathan L., Smallie, Tim, Buckley, Christopher D., Clark, Andrew R.
Published in Molecular and cellular biology (01.06.2017)
Published in Molecular and cellular biology (01.06.2017)
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Journal Article
Spontaneous Chemical Reversion of an Active Site Mutation: Deamidation of an Asparagine Residue Replacing the Catalytic Aspartic Acid of Glutamate Dehydrogenase
Paradisi, Francesca, Dean, Jonathan L. E, Geoghegan, Kieran F, Engel, Paul C
Published in Biochemistry (Easton) (08.03.2005)
Published in Biochemistry (Easton) (08.03.2005)
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Journal Article
TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-κB pathways and signals TRAF2 protein degradation in macrophages
Ruspi, Gerhard, Schmidt, Emily M., McCann, Fiona, Feldmann, Marc, Williams, Richard O., Stoop, A. Allart, Dean, Jonathan L.E.
Published in Cellular signalling (01.04.2014)
Published in Cellular signalling (01.04.2014)
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Journal Article
The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages
Tudor, Corina, Marchese, Francesco P., Hitti, Edward, Aubareda, Anna, Rawlinson, Lesley, Gaestel, Matthias, Blackshear, Perry J., Clark, Andrew R., Saklatvala, Jeremy, Dean, Jonathan L.E.
Published in FEBS letters (18.06.2009)
Published in FEBS letters (18.06.2009)
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NF-κB Suppression by the Deubiquitinating Enzyme Cezanne: A NOVEL NEGATIVE FEEDBACK LOOP IN PRO-INFLAMMATORY SIGNALING
Enesa, Karine, Zakkar, Mustafa, Chaudhury, Hera, Luong, Le A, Rawlinson, Lesley, Mason, Justin C, Haskard, Dorian O, Dean, Jonathan L.E, Evans, Paul C
Published in The Journal of biological chemistry (14.03.2008)
Published in The Journal of biological chemistry (14.03.2008)
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Journal Article
Mitogen-Activated Protein Kinase p38 Controls the Expression and Posttranslational Modification of Tristetraprolin, a Regulator of Tumor Necrosis Factor Alpha mRNA Stability
Mahtani, Kamal R., Brook, Matthew, Dean, Jonathan L. E., Sully, Gareth, Saklatvala, Jeremy, Clark, Andrew R.
Published in Molecular and Cellular Biology (01.10.2001)
Published in Molecular and Cellular Biology (01.10.2001)
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