Transport of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin by Human Organic Anion Transporter 3, Organic Anion Transporting Polypeptide 4C1, and Multidrug Resistance P-glycoprotein
Chu, Xiao-Yan, Bleasby, Kelly, Yabut, Jocelyn, Cai, Xiaoxin, Chan, Grace Hoyee, Hafey, Michael J, Xu, Shiyao, Bergman, Arthur J, Braun, Matthew P, Dean, Dennis C, Evers, Raymond
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2007)
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In Vitro Metabolic Activation of Lumiracoxib in Rat and Human Liver Preparations
Li, Ying, Slatter, J Greg, Zhang, Zhoupeng, Li, Yan, Doss, George A, Braun, Matthew P, Stearns, Ralph A, Dean, Dennis C, Baillie, Thomas A, Tang, Wei
Published in Drug metabolism and disposition (01.02.2008)
Published in Drug metabolism and disposition (01.02.2008)
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Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats
Schaefer, William H, Lawrence, Jeffery W, Loughlin, Amy F, Stoffregen, Dana A, Mixson, Lori A, Dean, Dennis C, Raab, Conrad E, Yu, Nathan X, Lankas, George R, Frederick, Clay B
Published in Toxicology and applied pharmacology (2004)
Published in Toxicology and applied pharmacology (2004)
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Metabolites of Caspofungin Acetate, a Potent Antifungal Agent, in Human Plasma and Urine
Balani, S K, Xu, X, Arison, B H, Silva, M V, Gries, A, DeLuna, F A, Cui, D, Kari, P H, Ly, T, Hop, C E, Singh, R, Wallace, M A, Dean, D C, Lin, J H, Pearson, P G, Baillie, T A
Published in Drug metabolism and disposition (01.11.2000)
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Published in Drug metabolism and disposition (01.11.2000)
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The Target of Ezetimibe Is Niemann-Pick C1-Like 1 (NPC1L1)
Garcia-Calvo, Margarita, Lisnock, JeanMarie, Bull, Herbert G., Hawes, Brian E., Burnett, Duane A., Braun, Matthew P., Crona, James H., Davis, Harry R., Dean, Dennis C., Detmers, Patricia A., Graziano, Michael P., Hughes, Meredith, MacIntyre, D. Euan, Ogawa, Anthony, O'Neill, Kim A., Sai Prasad N. Iyer, Shevell, Diane E., Smith, Marsha M., Tang, Yui S., Makarewicz, Amanda M., Ujjainwalla, Feroze, Altmann, Scott W., Chapman, Kevin T., Thornberry, Nancy A., Goldstein, Joseph L.
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2005)
Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2005)
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VALIDATION OF (-)-N-3-BENZYL-PHENOBARBITAL AS A SELECTIVE INHIBITOR OF CYP2C19 IN HUMAN LIVER MICROSOMES
XIAOXIN CAI, WANG, Regina W, EDOM, Richard W, EVANS, David C, MAGANG SHOU, RODRIGUES, A. David, WENSHENG LIU, DEAN, Dennis C, BAILLIE, Thomas A
Published in Drug metabolism and disposition (01.06.2004)
Published in Drug metabolism and disposition (01.06.2004)
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Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues
Feighner, Scott D, Howard, Andrew D, Prendergast, Kristine, Palyha, Oksana C, Hreniuk, Donna L, Nargund, Ravi, Underwood, Dennis, Tata, James R, Dean, Dennis C, Tan, Carina P, McKee, Karen Kulju, Woods, John W, Patchett, Arthur A, Smith, Roy G, Van der Ploeg, Lex H. T
Published in Molecular endocrinology (Baltimore, Md.) (01.01.1998)
Published in Molecular endocrinology (Baltimore, Md.) (01.01.1998)
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Simultaneous determination of a novel KDR kinase inhibitor and its N-oxide metabolite in human plasma using 96-well solid-phase extraction and liquid chromatography/tandem mass spectrometry
YANG XU, LIHONG DU, SOLI, Eric D, BRAUN, Matthew P, DEAN, Dennis C, MUSSON, Donald G
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (25.03.2005)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (25.03.2005)
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Comparative Assessment of the Ligand and Metal Ion Binding Properties of Integrins α9β1 and α4β1
Pepinsky, R. Blake, Mumford, Richard A, Chen, Ling Ling, Leone, Diane, Amo, Suzanne E, Riper, Gail Van, Whitty, Adrian, Dolinski, Brian, Lobb, Roy R, Dean, Dennis C, Chang, Linda L, Raab, Conrad E, Si, Qian, Hagmann, William K, Lingham, Russell B
Published in Biochemistry (Easton) (04.06.2002)
Published in Biochemistry (Easton) (04.06.2002)
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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Edmondson, Scott D., Wei, Lan, Xu, Jinyou, Shang, Jackie, Xu, Shiyao, Pang, Jianmei, Chaudhary, Ashok, Dean, Dennis C., He, Huaibing, Leiting, Barbara, Lyons, Kathryn A., Patel, Reshma A., Patel, Sangita B., Scapin, Giovanna, Wu, Joseph K., Beconi, Maria G., Thornberry, Nancy A., Weber, Ann E.
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys
TAN, Eugene Y, HARTMANN, Georgy, WEI TANG, KUMAR, Sanjeev, QING CHEN, PEREIRA, Antonio, BRADLEY, Scott, DOSS, George, ZHANG, Andy Shiqiang, HO, Jonathan Z, BRAUN, Matthew P, DEAN, Dennis C
Published in Drug metabolism and disposition (01.03.2010)
Published in Drug metabolism and disposition (01.03.2010)
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Journal Article
Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans
KUMAR, Sanjeev, TAN, Eugene Y, KARANAM, Bindhu, DEAN, Dennis C, GENDRANO, Isaias Noel, GRAVES, Mark W, WAGNER, John A, KRISHNA, Rajesh, HARTMANN, Georgy, BIDDLE, Zachary, BERGMAN, Arthur J, DRU, James, HO, Jonathan Z, JONES, Allen N, STASKIEWICZ, Steve J, BRAUN, Matthew P
Published in Drug metabolism and disposition (01.03.2010)
Published in Drug metabolism and disposition (01.03.2010)
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Identification of Metabolites of a Substance P (Neurokinin 1 Receptor) Antagonist in Rat Hepatocytes and Rat Plasma
HOP, Cornelis E. C. A, YANFENG WANG, CURTIS, Neil, ELLIOTT, Jason, GERHARD, Ute, LOCKER, Karen, MORRISON, Denise, MORTISHIRE-SMITH, Russell, THOMAS, Steven, WATT, Alan P, EVANS, David C, KUMAR, Sanjeev, SILVA ELIPE, Maria Victoria, RAAB, Conrad E, DEAN, Dennis C, POON, Grace K, KEOHANE, Carol-Ann, STRAUSS, John, CHIU, Shuet-Hing L
Published in Drug metabolism and disposition (01.08.2002)
Published in Drug metabolism and disposition (01.08.2002)
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Synthesis of Functionalized Azomethine Ylides via the Rh(II)-Catalyzed Cyclization of .alpha.-Diazo Carbonyls onto Imino .pi.-Bonds
Padwa, Albert, Dean, Dennis C, Osterhout, Martin H, Precedo, Laura, Semones, Mark A
Published in Journal of organic chemistry (01.09.1994)
Published in Journal of organic chemistry (01.09.1994)
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Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand
Wolkenberg, Scott E., Zhao, Zhijian, Kapitskaya, Marianna, Webber, Andrea L., Petrukhin, Konstantin, Tang, Yui Sing, Dean, Dennis C., Hartman, George D., Lindsley, Craig W.
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
Published in Bioorganic & medicinal chemistry letters (01.10.2006)
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Ivermectin and Nodulisporic Acid Receptors in Drosophila melanogaster Contain Both γ-Aminobutyric Acid-Gated Rdl and Glutamate-Gated GluClα Chloride Channel Subunits
Ludmerer, Steven W, Warren, Vivien A, Williams, Brande S, Zheng, Yingcong, Hunt, David C, Ayer, Michelle B, Wallace, Michael A, Chaudhary, Ashok G, Egan, Marjorie A, Meinke, Peter T, Dean, Dennis C, Garcia, Maria L, Cully, Doris F, Smith, McHardy M
Published in Biochemistry (Easton) (21.05.2002)
Published in Biochemistry (Easton) (21.05.2002)
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Multiple strategies for the preparation of a sulfur-35 labeled NPC1L1 radioligand
Simeone, Joseph P., Braun, Matthew P., Leone, Joseph F., Lin, Peter, DeVita, Robert J., Garcia-Calvo, Margarita, Bull, Herb G., Lisnock, JeanMarie, Dean, Dennis C.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Studies on Cytochrome P-450-Mediated Bioactivation of Diclofenac in Rats and in Human Hepatocytes: Identification of Glutathione Conjugated Metabolites
WEI TANG, STEARNS, R. A, STRAUSS, J. R, KWEI, G. Y, RUSHMORE, T. H, CHIU, S.-H. L, BAILLIE, T. A, BANDIERA, S. M, YONG ZHANG, RAAB, C, BRAUN, M. P, DEAN, D. C, JIANMEI PANG, LEUNG, K. H, DOSS, G. A
Published in Drug metabolism and disposition (01.03.1999)
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Published in Drug metabolism and disposition (01.03.1999)
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Vinylogous carbinolamine tumor inhibitors. 24. Synthesis, chemistry, and antineoplastic activity of .alpha.-halopyridinium salts: potential pyridone prodrugs of acylated vinylogous carbinolamine tumor inhibitors
Anderson, Wayne K, Dean, Dennis C, Endo, Toshiyasu
Published in Journal of medicinal chemistry (01.06.1990)
Published in Journal of medicinal chemistry (01.06.1990)
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