Search Results - "Deadman, John J" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design

Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design

by Peat, Thomas S, Rhodes, David I, Vandegraaff, Nick, Le, Giang, Smith, Jessica A, Clark, Lisa J, Jones, Eric D, Coates, Jonathan A V, Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J
Published in PloS one (10.07.2012)

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Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

Parallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?

by Wielens, Jerome, Headey, Stephen J, Rhodes, David I, Mulder, Roger J, Dolezal, Olan, Deadman, John J, Newman, Janet, Chalmers, David K, Parker, Michael W, Peat, Thomas S, Scanlon, Martin J
Published in Journal of biomolecular screening (01.02.2013)

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators

Design of a series of bicyclic HIV-1 integrase inhibitors. Part 2: Azoles: Effective metal chelators

by Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Thienthong, Neeranat, Winfield, Lisa J., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)

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Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

Correction: Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

by Peat, Thomas S., Rhodes, David I., Vandegraaff, Nick, Le, Giang, Smith, Jessica A., Clark, Lisa J., Jones, Eric D., Coates, Jonathan A. V., Thienthong, Neeranat, Newman, Janet, Dolezal, Olan, Mulder, Roger, Ryan, John H., Savage, G. Paul, Francis, Craig L., Deadman, John J.
Published in PloS one (24.07.2013)

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Interrogating HIV integrase for compounds that bind- a SAMPL challenge

Interrogating HIV integrase for compounds that bind- a SAMPL challenge

by Peat, Thomas S., Dolezal, Olan, Newman, Janet, Mobley, David, Deadman, John J.
Published in Journal of computer-aided molecular design (01.04.2014)

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Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library

by Spencer, John, Patel, Hiren, Amin, Jahangir, Callear, Samantha K., Coles, Simon J., Deadman, John J., Furman, Christophe, Mansouri, Roxane, Chavatte, Philippe, Millet, Régis
Published in Tetrahedron letters (28.03.2012)

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Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

Synthesis and solid state study of pyridine- and pyrimidine-based fragment libraries

by Spencer, John, Patel, Hiren, Callear, Samantha K., Coles, Simon J., Deadman, John J.
Published in Tetrahedron letters (09.11.2011)

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Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site

Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site

by Rhodes, David I., Peat, Thomas S., Vandegraaff, Nick, Jeevarajah, Dharshini, Newman, Janet, Martyn, John, Coates, Jonathan A. V., Ede, Nicholas J., Rea, Philip, Deadman, John J.
Published in Chembiochem : a European journal of chemical biology (17.10.2011)

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Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold

Design of a series of bicyclic HIV-1 integrase inhibitors. Part 1: Selection of the scaffold

by Jones, Eric D., Vandegraaff, Nick, Le, Giang, Choi, Neil, Issa, William, Macfarlane, Katherine, Thienthong, Neeranat, Winfield, Lisa J., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Feng, Xiao, Yu, Changjiang, Rhodes, David I., Deadman, John J.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)

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Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1

Fragment-Based Design of Ligands Targeting a Novel Site on the Integrase Enzyme of Human Immunodeficiency Virus 1

by Wielens, Jerome, Headey, Stephen J., Deadman, John J., Rhodes, David I., Parker, Michael W., Chalmers, David K., Scanlon, Martin J.
Published in ChemMedChem (07.02.2011)

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Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design

by Rhodes, David I, Peat, Thomas S, Vandegraaff, Nick, Jeevarajah, Dharshini, Le, Giang, Jones, Eric D, Smith, Jessica A, Coates, Jonathan A V, Winfield, Lisa J, Thienthong, Neeranat, Newman, Janet, Lucent, Del, Ryan, John H, Savage, G Paul, Francis, Craig L, Deadman, John J
Published in Antiviral chemistry & chemotherapy (07.03.2011)

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Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses

Discovery of potent HIV integrase inhibitors active against raltegravir resistant viruses

by Le, Giang, Vandegraaff, Nick, Rhodes, David I., Jones, Eric D., Coates, Jonathan A.V., Lu, Long, Li, Xinming, Yu, Changjiang, Feng, Xiao, Deadman, John J.
Published in Bioorganic & medicinal chemistry letters (01.09.2010)

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The unexpected but predictable tetrazole packing in flexible 1-benzyl-1H-tetrazole

The unexpected but predictable tetrazole packing in flexible 1-benzyl-1H-tetrazole

by Spencer, John, Patel, Hiren, Deadman, John J., Palmer, Rex A., Male, Louise, Coles, Simon J., Uzoh, Ogaga G., Price, Sarah L.
Published in CrystEngComm (01.01.2012)

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Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain

Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain

by Ryan, John H, Jarvis, Karen E, Mulder, Roger J, Francis, Craig L, Savage, G Paul, Dolezal, Olan, Peat, Thomas S, Deadman, John J
Published in Australian journal of chemistry (01.01.2015)

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Generation of Ligand Conformations in Continuum Solvent Consistent with Protein Active Site Topology: Application to Thrombin

Generation of Ligand Conformations in Continuum Solvent Consistent with Protein Active Site Topology: Application to Thrombin

by Greenidge, Paulette A, Mérette, Sandrine A. M, Beck, Richard, Dodson, Guy, Goodwin, Christopher A, Scully, Michael F, Spencer, John, Weiser, Jörg, Deadman, John J
Published in Journal of medicinal chemistry (10.04.2003)

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Assembly of Urokinase Receptor-Mediated Plasminogen Activation Complexes Involves Direct, Non-Active-Site Interactions between Urokinase and Plasminogen

Assembly of Urokinase Receptor-Mediated Plasminogen Activation Complexes Involves Direct, Non-Active-Site Interactions between Urokinase and Plasminogen

by Ellis, Vincent, Whawell, Simon A, Werner, Finn, Deadman, John J
Published in Biochemistry (Easton) (12.01.1999)

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Characterization of a Class of Peptide Boronates with Neutral P1 Side Chains as Highly Selective Inhibitors of Thrombin

Characterization of a Class of Peptide Boronates with Neutral P1 Side Chains as Highly Selective Inhibitors of Thrombin

by Deadman, John J, Elgendy, Said, Goodwin, Christopher A, Green, Donovan, Baban, Jehan A, Patel, Geeta, Skordalakes, Emmanuel, Chino, Naoyoshi, Claeson, Goran
Published in Journal of medicinal chemistry (01.04.1995)

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Bifunctional Peptide Boronate Inhibitors of Thrombin: Crystallographic Analysis of Inhibition Enhanced by Linkage to an Exosite 1 Binding Peptide

Bifunctional Peptide Boronate Inhibitors of Thrombin: Crystallographic Analysis of Inhibition Enhanced by Linkage to an Exosite 1 Binding Peptide

by Skordalakes, Emmanuel, Elgendy, Said, Goodwin, Christopher A, Green, Donovan, Scully, Michael F, Kakkar, Vijay V, Freyssinet, Jean-Marie, Dodson, Guy, Deadman, John J
Published in Biochemistry (Easton) (13.10.1998)

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Crystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel Interactions

Crystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel Interactions

by Skordalakes, Emmanuel, Tyrell, Richard, Elgendy, Said, Goodwin, Christopher A, Green, Donovan, Dodson, Guy, Scully, Michael F, Freyssinet, Jean-Marie H, Kakkar, Vijay V, Deadman, John J
Published in Journal of the American Chemical Society (15.10.1997)

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Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis

by Jarman, Michael, Barrie, S. Elaine, Deadman, John J, Houghton, John, McCague, Raymond, Rowlands, Martin G
Published in Journal of medicinal chemistry (01.09.1990)

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