Signal Transduction in Histidine Kinases: Insights from New Structures
Bhate, Manasi P., Molnar, Kathleen S., Goulian, Mark, DeGrado, William F.
Published in Structure (London) (02.06.2015)
Published in Structure (London) (02.06.2015)
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Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity
Schnaider, Lee, Brahmachari, Sayanti, Schmidt, Nathan W., Mensa, Bruk, Shaham-Niv, Shira, Bychenko, Darya, Adler-Abramovich, Lihi, Shimon, Linda J. W., Kolusheva, Sofiya, DeGrado, William F., Gazit, Ehud
Published in Nature communications (08.11.2017)
Published in Nature communications (08.11.2017)
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Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters
Thomaston, Jessica L, Polizzi, Nicholas F, Konstantinidi, Athina, Wang, Jun, Kolocouris, Antonios, DeGrado, William F
Published in Journal of the American Chemical Society (14.11.2018)
Published in Journal of the American Chemical Society (14.11.2018)
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Salt bridges: Geometrically specific, designable interactions
Donald, Jason E., Kulp, Daniel W., DeGrado, William F.
Published in Proteins, structure, function, and bioinformatics (01.03.2011)
Published in Proteins, structure, function, and bioinformatics (01.03.2011)
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Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers
Schmidt-Rohr, Klaus, Wang, Jun, Hong, Mei, DeGrado, William F, Cady, Sarah D, Soto, Cinque S
Published in Nature (London) (04.02.2010)
Published in Nature (London) (04.02.2010)
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De novo design of a transmembrane Zn2+-transporting four-helix bundle
Joh, Nathan H., Wang, Tuo, Bhate, Manasi P., Acharya, Rudresh, Wu, Yibing, Grabe, Michael, Hong, Mei, Grigoryan, Gevorg, DeGrado, William F.
Published in Science (American Association for the Advancement of Science) (19.12.2014)
Published in Science (American Association for the Advancement of Science) (19.12.2014)
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Packing of apolar side chains enables accurate design of highly stable membrane proteins
Mravic, Marco, Thomaston, Jessica L, Tucker, Maxwell, Solomon, Paige E, Liu, Lijun, DeGrado, William F
Published in Science (American Association for the Advancement of Science) (29.03.2019)
Published in Science (American Association for the Advancement of Science) (29.03.2019)
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Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments
Merz, Gregory E., Chalkley, Matthew J., Tan, Sophia K., Tse, Eric, Lee, Joanne, Prusiner, Stanley B., Paras, Nick A., DeGrado, William F., Southworth, Daniel R.
Published in Nature communications (26.05.2023)
Published in Nature communications (26.05.2023)
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Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
Wang, Jun, Wu, Yibing, Ma, Chunlong, Fiorin, Giacomo, Wang, Jizhou, Pinto, Lawrence H., Lamb, Robert A., Klein, Michael L., DeGrado, William F.
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (22.01.2013)
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Proximity-enhanced SuFEx chemical cross-linker for specific and multitargeting cross-linking mass spectrometry
Yang, Bing, Wu, Haifan, Schnier, Paul D., Liu, Yansheng, Liu, Jun, Wang, Nanxi, DeGrado, William F., Wang, Lei
Published in Proceedings of the National Academy of Sciences - PNAS (30.10.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (30.10.2018)
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Cys-Scanning Disulfide Crosslinking and Bayesian Modeling Probe the Transmembrane Signaling Mechanism of the Histidine Kinase, PhoQ
Molnar, Kathleen S., Bonomi, Massimiliano, Pellarin, Riccardo, Clinthorne, Graham D., Gonzalez, Gabriel, Goldberg, Shalom D., Goulian, Mark, Sali, Andrej, DeGrado, William F.
Published in Structure (London) (02.09.2014)
Published in Structure (London) (02.09.2014)
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Genetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins
Yang, Bing, Wang, Nanxi, Schnier, Paul D, Zheng, Feng, Zhu, He, Polizzi, Nicholas F, Ittuveetil, Avinash, Saikam, Varma, DeGrado, William F, Wang, Qian, Wang, Peng G, Wang, Lei
Published in Journal of the American Chemical Society (15.05.2019)
Published in Journal of the American Chemical Society (15.05.2019)
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Allosteric cooperation in a de novo-designed two-domain protein
Pirro, Fabio, Schmidt, Nathan, Lincoff, James, Widel, Zachary X., Polizzi, Nicholas F., Liu, Lijun, Therien, Michael J., Grabe, Michael, Chino, Marco, Lombardi, Angela, DeGrado, William F.
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (29.12.2020)
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