Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives
Muthiah, Divya, Henshaw, Georgia K, DeBono, Aaron J, Capuano, Ben, Scammells, Peter J, Callaghan, Richard
Published in Drug metabolism and disposition (01.02.2019)
Published in Drug metabolism and disposition (01.02.2019)
Get full text
Journal Article
Substituted Pyridazin-3(2H)‑ones as Highly Potent and Biased Formyl Peptide Receptor Agonists
Deora, Girdhar Singh, Qin, Cheng Xue, Vecchio, Elizabeth A, Debono, Aaron J, Priebbenow, Daniel L, Brady, Ryan M, Beveridge, Julia, Teguh, Silvia C, Deo, Minh, May, Lauren T, Krippner, Guy, Ritchie, Rebecca H, Baell, Jonathan B
Published in Journal of medicinal chemistry (23.05.2019)
Published in Journal of medicinal chemistry (23.05.2019)
Get full text
Journal Article
8‐Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase
Dennis, Matthew L., Lee, Michael D., Harjani, Jitendra R., Ahmed, Mohamed, DeBono, Aaron J., Pitcher, Noel P., Wang, Zhong‐Chang, Chhabra, Sandeep, Barlow, Nicholas, Rahmani, Raphaël, Cleary, Ben, Dolezal, Olan, Hattarki, Meghan, Aurelio, Luigi, Shonberg, Jeremy, Graham, Bim, Peat, Thomas S., Baell, Jonathan B., Swarbrick, James D.
Published in Chemistry : a European journal (06.02.2018)
Published in Chemistry : a European journal (06.02.2018)
Get full text
Journal Article
Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'
Qin, Cheng Xue, May, Lauren T, Sexton, Patrick M, DeBono, Aaron J, Baell, Jonathan B, Christopoulos, Arthur, Ritchie, Rebecca H
Published in Nature communications (07.02.2018)
Published in Nature communications (07.02.2018)
Get full text
Journal Article
Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity
DeBono, Aaron, Thomas, David R, Lundberg, Lindsay, Pinkham, Chelsea, Cao, Ying, Graham, J Dinny, Clarke, Christine L, Wagstaff, Kylie M, Shechter, Sharon, Kehn-Hall, Kylene, Jans, David A
Published in Scientific reports (22.02.2019)
Published in Scientific reports (22.02.2019)
Get full text
Journal Article
Structural Basis for the Selective Binding of Inhibitors to 6‑Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli
Dennis, Matthew L, Pitcher, Noel P, Lee, Michael D, DeBono, Aaron J, Wang, Zhong-Chang, Harjani, Jitendra R, Rahmani, Raphaël, Cleary, Ben, Peat, Thomas S, Baell, Jonathan B, Swarbrick, James D
Published in Journal of medicinal chemistry (09.06.2016)
Published in Journal of medicinal chemistry (09.06.2016)
Get full text
Journal Article
The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine as Cytotoxic Agents
DeBono, Aaron J., Mistry, Sarah J., Xie, Jinhan, Muthiah, Divya, Phillips, Jackson, Ventura, Sabatino, Callaghan, Richard, Pouton, Colin W., Capuano, Ben, Scammells, Peter J.
Published in ChemMedChem (01.02.2014)
Published in ChemMedChem (01.02.2014)
Get full text
Journal Article
Progress Toward the Development of Noscapine and Derivatives as Anticancer Agents
DeBono, Aaron, Capuano, Ben, Scammells, Peter J
Published in Journal of medicinal chemistry (13.08.2015)
Published in Journal of medicinal chemistry (13.08.2015)
Get full text
Journal Article
Identification of novel antivirals inhibiting recognition of Venezuelan equine encephalitis virus capsid protein by the Importin α/β1 heterodimer through high-throughput screening
Thomas, David R., Lundberg, Lindsay, Pinkham, Chelsea, Shechter, Sharon, DeBono, Aaron, Baell, Jonathan, Wagstaff, Kylie M., Hick, Caroline A., Kehn-Hall, Kylene, Jans, David A.
Published in Antiviral research (01.03.2018)
Published in Antiviral research (01.03.2018)
Get full text
Journal Article
Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design
Shechter, Sharon, Thomas, David R, Lundberg, Lindsay, Pinkham, Chelsea, Lin, Shih-Chao, Wagstaff, Kylie M, Debono, Aaron, Kehn-Hall, Kylene, Jans, David A
Published in Scientific reports (18.12.2017)
Published in Scientific reports (18.12.2017)
Get full text
Journal Article
Negative allosteric modulators of the human calcium‐sensing receptor bind to overlapping and distinct sites within the 7‐transmembrane domain
Josephs, Tracy M., Keller, Andrew N., Khajehali, Elham, DeBono, Aaron, Langmead, Christopher J., Conigrave, Arthur D., Capuano, Ben, Kufareva, Irina, Gregory, Karen J., Leach, Katie
Published in British journal of pharmacology (01.04.2020)
Published in British journal of pharmacology (01.04.2020)
Get full text
Journal Article
Development of AC265347‐Inspired Calcium‐Sensing Receptor Ago‐Positive Allosteric Modulators
Dinh, Le Vi, DeBono, Aaron, Keller, Andrew N., Josephs, Tracy M., Gregory, Karen J., Leach, Katie, Capuano, Ben
Published in ChemMedChem (19.11.2021)
Published in ChemMedChem (19.11.2021)
Get full text
Journal Article
Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor
Diao, Jiayin, DeBono, Aaron, Josephs, Tracy M, Bourke, Jane E, Capuano, Ben, Gregory, Karen J, Leach, Katie
Published in ACS pharmacology & translational science (09.04.2021)
Published in ACS pharmacology & translational science (09.04.2021)
Get full text
Journal Article
Author Correction: Novel inhibitors targeting Venezuelan equine encephalitis virus capsid protein identified using In Silico Structure-Based-Drug-Design
Shechter, Sharon, Thomas, David R, Lundberg, Lindsay, Pinkham, Chelsea, Lin, Shih-Chao, Wagstaff, Kylie M, Debono, Aaron, Kehn-Hall, Kylene, Jans, David A
Published in Scientific reports (04.09.2018)
Published in Scientific reports (04.09.2018)
Get full text
Journal Article
Structure-Based Design and Development of Functionalized Mercaptoguanine Derivatives as Inhibitors of the Folate Biosynthesis Pathway Enzyme 6‑Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus
Dennis, Matthew L, Chhabra, Sandeep, Wang, Zhong-Chang, Debono, Aaron, Dolezal, Olan, Newman, Janet, Pitcher, Noel P, Rahmani, Raphael, Cleary, Ben, Barlow, Nicholas, Hattarki, Meghan, Graham, Bim, Peat, Thomas S, Baell, Jonathan B, Swarbrick, James D
Published in Journal of medicinal chemistry (26.11.2014)
Published in Journal of medicinal chemistry (26.11.2014)
Get full text
Journal Article