Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
Chen, Serene W., Drakulic, Srdja, Deas, Emma, Ouberai, Myriam, Aprile, Francesco A., Arranz, Rocío, Ness, Samuel, Roodveldt, Cintia, Guilliams, Tim, De-Genst, Erwin J., Klenerman, David, Wood, Nicholas W., Knowles, Tuomas P.J., Alfonso, Carlos, Rivas, Germán, Abramov, Andrey Y., Valpuesta, José María, Dobson, Christopher M., Cremades, Nunilo
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2015)
Get full text
Journal Article
Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions
Arosio, Paolo, Müller, Thomas, Rajah, Luke, Yates, Emma V, Aprile, Francesco A, Zhang, Yingbo, Cohen, Samuel I. A, White, Duncan A, Herling, Therese W, De Genst, Erwin J, Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M, Knowles, Tuomas P. J
Published in ACS nano (26.01.2016)
Published in ACS nano (26.01.2016)
Get full text
Journal Article
Latent analysis of unmodified biomolecules and their complexes in solution with attomole detection sensitivity
Yates, Emma V, Müller, Thomas, Rajah, Luke, De Genst, Erwin J, Arosio, Paolo, Linse, Sara, Vendruscolo, Michele, Dobson, Christopher M, Knowles, Tuomas P J
Published in Nature chemistry (01.10.2015)
Published in Nature chemistry (01.10.2015)
Get full text
Journal Article
Observation of spatial propagation of amyloid assembly from single nuclei
Knowles, Tuomas P. J, White, Duncan A, Abate, Adam R, Agresti, Jeremy J, Cohen, Samuel I. A, Sperling, Ralph A, De Genst, Erwin J, Dobson, Christopher M, Weitz, David A
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (06.09.2011)
Get full text
Journal Article
Structure and Properties of a Complex of α-Synuclein and a Single-Domain Camelid Antibody
De Genst, Erwin J., Guilliams, Tim, Wellens, Joke, O'Day, Elizabeth M., Waudby, Christopher A., Meehan, Sarah, Dumoulin, Mireille, Hsu, Shang-Te Danny, Cremades, Nunilo, Verschueren, Koen H.G., Pardon, Els, Wyns, Lode, Steyaert, Jan, Christodoulou, John, Dobson, Christopher M.
Published in Journal of molecular biology (17.09.2010)
Published in Journal of molecular biology (17.09.2010)
Get full text
Journal Article
Web Resource
Immunization with α‐synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model
Villadiego, Javier, Labrador‐Garrido, Adahir, Franco, Jaime M., Leal‐Lasarte, Magdalena, De Genst, Erwin J., Dobson, Christopher M., Pozo, David, Toledo‐Aral, Juan J., Roodveldt, Cintia
Published in Glia (01.01.2018)
Published in Glia (01.01.2018)
Get full text
Journal Article
Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the α-synuclein-elicited immune response
Labrador-Garrido, Adahir, Cejudo-Guillén, Marta, Daturpalli, Soumya, Leal, María M, Klippstein, Rebecca, De Genst, Erwin J, Villadiego, Javier, Toledo-Aral, Juan J, Dobson, Christopher M, Jackson, Sophie E, Pozo, David, Roodveldt, Cintia
Published in The FASEB journal (01.02.2016)
Published in The FASEB journal (01.02.2016)
Get more information
Journal Article
A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α‑Synuclein and β‑Synuclein
Roodveldt, Cintia, Andersson, August, De Genst, Erwin J, Labrador-Garrido, Adahir, Buell, Alexander K, Dobson, Christopher M, Tartaglia, Gian Gaetano, Vendruscolo, Michele
Published in Biochemistry (Easton) (06.11.2012)
Published in Biochemistry (Easton) (06.11.2012)
Get full text
Journal Article
Chaperoned amyloid proteins for immune manipulation: α‐Synuclein/Hsp70 shifts immunity toward a modulatory phenotype
Labrador‐Garrido, Adahir, Cejudo‐Guillén, Marta, Klippstein, Rebecca, De Genst, Erwin J., Tomas‐Gallardo, Laura, Leal, María M., Villadiego, Javier, Toledo‐Aral, Juan J., Dobson, Christopher M., Pozo, David, Roodveldt, Cintia
Published in Immunity, Inflammation and Disease (01.12.2014)
Published in Immunity, Inflammation and Disease (01.12.2014)
Get full text
Journal Article
Phage display and kinetic selection of antibodies that specifically inhibit amyloid self-replication
Munke, Anna, Persson, Jonas, Weiffert, Tanja, De Genst, Erwin, Meisl, Georg, Arosio, Paolo, Carnerup, Anna, Dobson, Christopher M., Vendruscolo, Michele, Knowles, Tuomas P. J., Linse, Sara
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2017)
Get full text
Journal Article
Immunization with [alpha]-synuclein/Grp94 reshapes peripheral immunity and suppresses microgliosis in a chronic Parkinsonism model
Villadiego, Javier, Labrador-Garrido, Adahir, Franco, Jaime M, Leal-Lasarte, Magdalena, De Genst, Erwin J, Dobson, Christopher M, Pozo, David, Toledo-Aral, Juan J, Roodveldt, Cintia
Published in Glia (01.01.2018)
Published in Glia (01.01.2018)
Get full text
Journal Article
Structural characterization of toxic oligomers that are kinetically trapped during [alpha]-synuclein fibril formation
Chen, Serene W, Drakulic, Srdja, Deas, Emma, Ouberai, Myriam, Aprile, Francesco A, Arranz, Rocío, Ness, Samuel, Roodveldt, Cintia, Guilliams, Tim, De-Genst, Erwin J, Klenerman, David, Wood, Nicholas W, Knowles, Tuomas PJ, Alfonso, Carlos, Rivas, Germán, Abramov, Andrey Y, Valpuesta, José María, Dobson, Christopher M, Cremades, Nunilo
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2015)
Get full text
Published in Proceedings of the National Academy of Sciences - PNAS (21.04.2015)
Journal Article
Journal of Molecular Biology
De Genst, Erwin J, Guilliams, Tim, Wellens, Joke, O'Day, Elizabeth M, Waudby, Christopher A, Meehan, Sarah, Dumoulin, Mireille, Hsu, Shang-Te Danny, Cremades, Nunilo, Verschueren, Koen H G, Pardon, Els, Wyns, Lode, Steyaert, Jan, Christodoulou, John, Dobson, Christopher M
Published in Journal of molecular biology (2010)
Get full text
Published in Journal of molecular biology (2010)
Journal Article