Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice
van den Berg, S M, Seijkens, T T P, Kusters, P J H, Zarzycka, B, Beckers, L, den Toom, M, Gijbels, M J J, Chatzigeorgiou, A, Weber, C, de Winther, M P J, Chavakis, T, Nicolaes, G A F, Lutgens, E
Published in International Journal of Obesity (01.05.2015)
Published in International Journal of Obesity (01.05.2015)
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Disruption of hedgehog signalling in ApoE − /− mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages
Beckers, L, Heeneman, S, Wang, L, Burkly, LC, Rousch, MMJ, Davidson, NO, Gijbels, MJJ, de Winther, MPJ, Daemen, MJAP, Lutgens, E
Published in The Journal of pathology (01.08.2007)
Published in The Journal of pathology (01.08.2007)
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Myeloid CD40 deficiency reduces atherosclerosis by impairing macrophages’ transition into a pro-inflammatory state
Bosmans, Laura A, van Tiel, Claudia M, Aarts, Suzanne A B M, Willemsen, Lisa, Baardman, Jeroen, van Os, Bram W, Toom, Myrthe den, Beckers, Linda, Ahern, David J, Levels, Johannes H M, Jongejan, Aldo, Moerland, Perry D, Verberk, Sanne G S, den Bossche, Jan van, de Winther, Menno M P J, Weber, Christian, Atzler, Dorothee, Monaco, Claudia, Gerdes, Norbert, Shami, Annelie, Lutgens, Esther
Published in Cardiovascular research (22.05.2023)
Published in Cardiovascular research (22.05.2023)
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IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement
van Dam, A D, van Beek, L, Pronk, A C M, van den Berg, S M, Van den Bossche, J, de Winther, M P J, Koning, F, van Kooten, C, Rensen, P C N, Boon, M R, Verbeek, J S, van Dijk, K Willems, van Harmelen, V
Published in International Journal of Obesity (01.02.2018)
Published in International Journal of Obesity (01.02.2018)
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Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic
Lutgens, SPM, Kisters, N, Lutgens, E, van Haaften, RIM, Evelo, CTA, de Winther, MPJ, Saftig, P, Daemen, MJAP, Heeneman, S, Cleutjens, KBJM
Published in The Journal of pathology (01.11.2006)
Published in The Journal of pathology (01.11.2006)
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Disruption of the Cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation
LUTGENS, E, LUTGENS, S. P. M, FISHER, A, LONG, C. J, SAFTIG, P, BLACK, D, DAEMEN, M. J. A. P, CLEUTJENS, K. B. J. M, FABER, B. C. G, HEENEMAN, S, GIJBELS, M. M. J, DE WINTHER, M. P. J, FREDERIK, P, VAN DER MADE, I, DAUGHERTY, A, SIJBERS, A. M
Published in Circulation (New York, N.Y.) (03.01.2006)
Published in Circulation (New York, N.Y.) (03.01.2006)
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Untangling the inflammatory responses of liver x receptor (LXR) activation in human macrophages
Zijlstra, L F, Kempkes, R W M, Giera, M A, Rensen, P C N, Kooijman, S, De Winther, M P J, Neele, A E
Published in Cardiovascular research (29.05.2024)
Published in Cardiovascular research (29.05.2024)
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Journal Article
Leukocyte CD40L deficiency affects the CD25 + CD4 T cell population but does not affect atherosclerosis
Smook, M.L.F., Heeringa, P., Damoiseaux, J.G.M.C., Daemen, M.J.A.P., de Winther, M.P.J., Gijbels, M.J.J., Beckers, L., Lutgens, E., Cohen Tervaert, J.W.
Published in Atherosclerosis (01.12.2005)
Published in Atherosclerosis (01.12.2005)
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EZH2 inhibition reduces macrophage inflammatory responses in atherosclerosis
Kempkes, R W M, Rief, L C M, Roomen, C P A A, Griffith, G R, Vos, W G, Bosmans, L A, Gijbels, M J J, Hoeksema, M A, Prange, K H M, De Winther, M P J, Neele, A E
Published in Cardiovascular research (29.05.2024)
Published in Cardiovascular research (29.05.2024)
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Human atherosclerotic plaque macrophages associate with clinical presentation and follow diverse lineage differentiation routes
Prange, K, Bel-Bordes, G, Depuydt, M A C, Kempkes, R W M, De Jong, M D M, Mol, B M, Slutter, B, Bot, I, Neele, A E, De Kleijn, D P V, De Borst, G J, Kuiper, J, Pasterkamp, G, Mokry, M, De Winther, M P J
Published in Cardiovascular research (29.05.2024)
Published in Cardiovascular research (29.05.2024)
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A single-cell atlas of immune checkpoint molecules in atherosclerosis in ApoE-/- mice
Bazioti, V, Bosmans, L A, Van Tiel, C M, Joppich, M, Ahern, D J, Shami, A, Weber, C, De Winther, M M P J, Atzler, D, Monaco, C, Lutgens, E
Published in European heart journal (09.11.2023)
Published in European heart journal (09.11.2023)
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Journal Article
IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fc[gamma]-receptor or complement
van Dam, A D, van Beek, L, Pronk, A C M, van den Berg, S M, Van den Bossche, J, de Winther, M P J, Koning, F, van Kooten, C, Rensen, P C N, Boon, M R, Verbeek, J S, van Dijk, K Willems, van Harmelen, V
Published in International Journal of Obesity (01.02.2018)
Published in International Journal of Obesity (01.02.2018)
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Myeloid A Disintegrin And Metalloprotease ADAM10 deficiency promotes atherosclerotic plaque stability by increasing fibrosis
Van Der Vorst, E., Wolfs, I. M. J., Weber, S., Gijbels, M. J., Rose-John, S., Ludwig, A., De Winther, M. P. J., Biessen, E. A. L., Saftig, P., Donners, M. M. P. C.
Published in European heart journal (02.08.2013)
Published in European heart journal (02.08.2013)
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Abstract 51: Parasitic Soluble Egg Antigens Fight Atherosclerosis from 2 Different Angles
Wolfs, Ine M, Goossens, P, Stöger, J L, Pöttgens, C, Gijbels, M, Wijnands, E, van Die, I, Kraal, G, J de Winther, M P
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2012)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.05.2012)
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Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice
de Winther, Menno P.J., Gijbels, Marion J.J., van Dijk, Ko Willems, van Gorp, Patrick J.J., Suzuki, Hiroshi, Kodama, Tatsuhiko, Frants, Rune R., Havekes, Louis M., Hofker, Marten H.
Published in Atherosclerosis (01.06.1999)
Published in Atherosclerosis (01.06.1999)
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Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages
de Winther, Menno P.J, van Dijk, Ko Willems, van Vlijmen, Bart J.M, Gijbels, Marion J.J, Heus, Joris J, Wijers, Edwin R, van den Bos, Alida C, Breuer, Marco, Frants, Rune R, Havekes, Louis M, Hofker, Marten H
Published in Atherosclerosis (01.12.1999)
Published in Atherosclerosis (01.12.1999)
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Hyperlipidemia of ApoE2(Arg158-Cys) and ApoE3-Leiden Transgenic Mice Is Modulated Predominantly by LDL Receptor Expression
van Dijk, Ko Willems, van Vlijmen, Bart J. M, de Winther, Menno P. J, Hof, Belinda van ’t, van der Zee, Andre, van der Boom, Hans, Havekes, Louis M, Hofker, Marten H
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1999)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.12.1999)
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Role of thiol homeostasis and adenine nucleotide metabolism in the protective effects of fructose in quinone-indudced cytotoxicity in rat hepatocytes
TOXOPEUS, C, VAN HOLSTEIJN, I, DE WINTHER, M. P. J, VAN DEN BODDELBSTEEN, D, HORBACH, G. J. M. J, BLAAUBOER, B. J, NOORDHOEK, J
Published in Biochemical pharmacology (1994)
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Published in Biochemical pharmacology (1994)
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