The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
Karran, Eric, Mercken, Marc, Strooper, Bart De
Published in Nature reviews. Drug discovery (01.09.2011)
Published in Nature reviews. Drug discovery (01.09.2011)
Get full text
Journal Article
Identifying individuals with high risk of Alzheimer’s disease using polygenic risk scores
Leonenko, Ganna, Baker, Emily, Stevenson-Hoare, Joshua, Sierksma, Annerieke, Fiers, Mark, Williams, Julie, de Strooper, Bart, Escott-Price, Valentina
Published in Nature communications (23.07.2021)
Published in Nature communications (23.07.2021)
Get full text
Journal Article
Tau association with synaptic vesicles causes presynaptic dysfunction
Zhou, Lujia, McInnes, Joseph, Wierda, Keimpe, Holt, Matthew, Herrmann, Abigail G., Jackson, Rosemary J., Wang, Yu-Chun, Swerts, Jef, Beyens, Jelle, Miskiewicz, Katarzyna, Vilain, Sven, Dewachter, Ilse, Moechars, Diederik, De Strooper, Bart, Spires-Jones, Tara L., De Wit, Joris, Verstreken, Patrik
Published in Nature communications (11.05.2017)
Published in Nature communications (11.05.2017)
Get full text
Journal Article
The case for low-level BACE1 inhibition for the prevention of Alzheimer disease
McDade, Eric, Voytyuk, Iryna, Aisen, Paul, Bateman, Randall J., Carrillo, Maria C., De Strooper, Bart, Haass, Christian, Reiman, Eric M., Sperling, Reisa, Tariot, Pierre N., Yan, Riqiang, Masters, Colin L., Vassar, Robert, Lichtenthaler, Stefan F.
Published in Nature reviews. Neurology (01.11.2021)
Published in Nature reviews. Neurology (01.11.2021)
Get full text
Journal Article
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation
Calafate, Sara, Buist, Arjan, Miskiewicz, Katarzyna, Vijayan, Vinoy, Daneels, Guy, de Strooper, Bart, de Wit, Joris, Verstreken, Patrik, Moechars, Diederik
Published in Cell reports (Cambridge) (26.05.2015)
Published in Cell reports (Cambridge) (26.05.2015)
Get full text
Journal Article
Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer’s disease: a case series
Ryan, Natalie S, Dr, Nicholas, Jennifer M, PhD, Weston, Philip S J, MRCP, Liang, Yuying, MRCP, Lashley, Tammaryn, PhD, Guerreiro, Rita, PhD, Adamson, Gary, BSc, Kenny, Janna, MRCP, Beck, Jon, FRCPath, Chavez-Gutierrez, Lucia, PhD, de Strooper, Bart, Prof, Revesz, Tamas, Prof, Holton, Janice, Prof, Mead, Simon, Prof, Rossor, Martin N, Prof, Fox, Nick C, Prof
Published in Lancet neurology (01.12.2016)
Published in Lancet neurology (01.12.2016)
Get full text
Journal Article
The amyloid precursor protein is a conserved Wnt receptor
Liu, Tengyuan, Zhang, Tingting, Nicolas, Maya, Boussicault, Lydie, Rice, Heather, Soldano, Alessia, Claeys, Annelies, Petrova, Iveta, Fradkin, Lee, De Strooper, Bart, Potier, Marie-Claude, Hassan, Bassem A
Published in eLife (09.09.2021)
Published in eLife (09.09.2021)
Get full text
Journal Article
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome
Pasciuto, Emanuela, Ahmed, Tariq, Wahle, Tina, Gardoni, Fabrizio, D’Andrea, Laura, Pacini, Laura, Jacquemont, Sébastien, Tassone, Flora, Balschun, Detlef, Dotti, Carlos G., Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Müller, Ulrike C., Di Luca, Monica, De Strooper, Bart, Bagni, Claudia
Published in Neuron (Cambridge, Mass.) (15.07.2015)
Published in Neuron (Cambridge, Mass.) (15.07.2015)
Get full text
Journal Article
Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures
Glomski, Krzysztof, Monette, Sébastien, Manova, Katia, De Strooper, Bart, Saftig, Paul, Blobel, Carl P.
Published in Blood (28.07.2011)
Published in Blood (28.07.2011)
Get full text
Journal Article
Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse
Barão, Soraia, Gärtner, Annette, Leyva-Díaz, Eduardo, Demyanenko, Galina, Munck, Sebastian, Vanhoutvin, Tine, Zhou, Lujia, Schachner, Melitta, López-Bendito, Guillermina, Maness, Patricia F., De Strooper, Bart
Published in Cell reports (Cambridge) (01.09.2015)
Published in Cell reports (Cambridge) (01.09.2015)
Get full text
Journal Article
Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy
Haddad, Dominik M., Vilain, Sven, Vos, Melissa, Esposito, Giovanni, Matta, Samer, Kalscheuer, Vera M., Craessaerts, Katleen, Leyssen, Maarten, Nascimento, Rafaella M.P., Vianna-Morgante, Angela M., De Strooper, Bart, Van Esch, Hilde, Morais, Vanessa A., Verstreken, Patrik
Published in Molecular cell (27.06.2013)
Published in Molecular cell (27.06.2013)
Get full text
Journal Article
The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants
Vilain, Sven, Esposito, Giovanni, Haddad, Dominik, Schaap, Onno, Dobreva, Mariya P, Vos, Melissa, Van Meensel, Stefanie, Morais, Vanessa A, De Strooper, Bart, Verstreken, Patrik
Published in PLoS genetics (01.01.2012)
Published in PLoS genetics (01.01.2012)
Get full text
Journal Article
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice
Papadopoulou, Aikaterini S, Serneels, Lutgarde, Achsel, Tilmann, Mandemakers, Wim, Callaerts-Vegh, Zsuzsanna, Dooley, James, Lau, Pierre, Ayoubi, Torik, Radaelli, Enrico, Spinazzi, Marco, Neumann, Melanie, Hébert, Sébastien S, Silahtaroglu, Asli, Liston, Adrian, D'Hooge, Rudi, Glatzel, Markus, De Strooper, Bart
Published in Neurobiology of disease (2015)
Published in Neurobiology of disease (2015)
Get full text
Journal Article