Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer’s Disease
Voytyuk, Iryna, De Strooper, Bart, Chávez-Gutiérrez, Lucía
Published in Biological psychiatry (1969) (15.02.2018)
Published in Biological psychiatry (1969) (15.02.2018)
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Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease
De Strooper, Bart, Iwatsubo, Takeshi, Wolfe, Michael S
Published in Cold Spring Harbor perspectives in medicine (01.01.2012)
Published in Cold Spring Harbor perspectives in medicine (01.01.2012)
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Journal Article
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
Cornelissen, Tom, Haddad, Dominik, Wauters, Fieke, Van Humbeeck, Cindy, Mandemakers, Wim, Koentjoro, Brianada, Sue, Carolyn, Gevaert, Kris, De Strooper, Bart, Verstreken, Patrik, Vandenberghe, Wim
Published in Human Molecular Genetics (01.10.2014)
Published in Human Molecular Genetics (01.10.2014)
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Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans
Thrupp, Nicola, Sala Frigerio, Carlo, Wolfs, Leen, Skene, Nathan G., Fattorelli, Nicola, Poovathingal, Suresh, Fourne, Yannick, Matthews, Paul M., Theys, Tom, Mancuso, Renzo, de Strooper, Bart, Fiers, Mark
Published in Cell reports (Cambridge) (29.09.2020)
Published in Cell reports (Cambridge) (29.09.2020)
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Journal Article
APP mouse models for Alzheimer's disease preclinical studies
Sasaguri, Hiroki, Nilsson, Per, Hashimoto, Shoko, Nagata, Kenichi, Saito, Takashi, De Strooper, Bart, Hardy, John, Vassar, Robert, Winblad, Bengt, Saido, Takaomi C
Published in The EMBO journal (01.09.2017)
Published in The EMBO journal (01.09.2017)
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Journal Article
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques
Sala Frigerio, Carlo, Wolfs, Leen, Fattorelli, Nicola, Thrupp, Nicola, Voytyuk, Iryna, Schmidt, Inga, Mancuso, Renzo, Chen, Wei-Ting, Woodbury, Maya E., Srivastava, Gyan, Möller, Thomas, Hudry, Eloise, Das, Sudeshna, Saido, Takaomi, Karran, Eric, Hyman, Bradley, Perry, V. Hugh, Fiers, Mark, De Strooper, Bart
Published in Cell reports (Cambridge) (23.04.2019)
Published in Cell reports (Cambridge) (23.04.2019)
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Journal Article
Neurodegeneration: From cellular concepts to clinical applications
Katsnelson, Alla, De Strooper, Bart, Zoghbi, Huda Y
Published in Science translational medicine (09.11.2016)
Published in Science translational medicine (09.11.2016)
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Journal Article
Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease
Stevenson-Hoare, Joshua, Heslegrave, Amanda, Leonenko, Ganna, Fathalla, Dina, Bellou, Eftychia, Luckcuck, Lauren, Marshall, Rachel, Sims, Rebecca, Morgan, Bryan Paul, Hardy, John, de Strooper, Bart, Williams, Julie, Zetterberg, Henrik, Escott-Price, Valentina
Published in Brain (London, England : 1878) (13.02.2023)
Published in Brain (London, England : 1878) (13.02.2023)
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In Vitro Studies of Flemish, Dutch, and Wild-Type β-Amyloid Provide Evidence for Two-Staged Neurotoxicity
Kumar-Singh, Samir, Julliams, Ann, Nuydens, Rony, Ceuterick, Chantal, Labeur, Christine, Serneels, Sally, Vennekens, Krist'l, Van Osta, Peter, Geerts, Hugo, De Strooper, Bart, Van Broeckhoven, Christine
Published in Neurobiology of disease (01.11.2002)
Published in Neurobiology of disease (01.11.2002)
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Journal Article
Stem-cell-derived human microglia transplanted in mouse brain to study human disease
Mancuso, Renzo, Van Den Daele, Johanna, Fattorelli, Nicola, Wolfs, Leen, Balusu, Sriram, Burton, Oliver, Liston, Adrian, Sierksma, Annerieke, Fourne, Yannick, Poovathingal, Suresh, Arranz-Mendiguren, Amaia, Sala Frigerio, Carlo, Claes, Christel, Serneels, Lutgarde, Theys, Tom, Perry, V. Hugh, Verfaillie, Catherine, Fiers, Mark, De Strooper, Bart
Published in Nature neuroscience (01.12.2019)
Published in Nature neuroscience (01.12.2019)
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A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals
Soukup, Sandra-Fausia, Kuenen, Sabine, Vanhauwaert, Roeland, Manetsberger, Julia, Hernández-Díaz, Sergio, Swerts, Jef, Schoovaerts, Nils, Vilain, Sven, Gounko, Natalia V., Vints, Katlijn, Geens, Ann, De Strooper, Bart, Verstreken, Patrik
Published in Neuron (Cambridge, Mass.) (23.11.2016)
Published in Neuron (Cambridge, Mass.) (23.11.2016)
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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
Balusu, Sriram, Horré, Katrien, Thrupp, Nicola, Craessaerts, Katleen, Snellinx, An, Serneels, Lutgarde, T’Syen, Dries, Chrysidou, Iordana, Arranz, Amaia M., Sierksma, Annerieke, Simrén, Joel, Karikari, Thomas K., Zetterberg, Henrik, Chen, Wei-Ting, Thal, Dietmar Rudolf, Salta, Evgenia, Fiers, Mark, De Strooper, Bart
Published in Science (American Association for the Advancement of Science) (15.09.2023)
Published in Science (American Association for the Advancement of Science) (15.09.2023)
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Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer’s disease
Walgrave, Hannah, Balusu, Sriram, Snoeck, Sarah, Vanden Eynden, Elke, Craessaerts, Katleen, Thrupp, Nicky, Wolfs, Leen, Horré, Katrien, Fourne, Yannick, Ronisz, Alicja, Silajdžić, Edina, Penning, Amber, Tosoni, Giorgia, Callaerts-Vegh, Zsuzsanna, D’Hooge, Rudi, Thal, Dietmar Rudolf, Zetterberg, Henrik, Thuret, Sandrine, Fiers, Mark, Frigerio, Carlo Sala, De Strooper, Bart, Salta, Evgenia
Published in Cell stem cell (07.10.2021)
Published in Cell stem cell (07.10.2021)
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