Retargeting azithromycin analogues to have dual-modality antimalarial activity
Burns, Amy L, Sleebs, Brad E, Siddiqui, Ghizal, De Paoli, Amanda E, Anderson, Dovile, Liffner, Benjamin, Harvey, Richard, Beeson, James G, Creek, Darren J, Goodman, Christopher D, McFadden, Geoffrey I, Wilson, Danny W
Published in BMC biology (29.09.2020)
Published in BMC biology (29.09.2020)
Get full text
Journal Article
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
Giannangelo, Carlo, Siddiqui, Ghizal, De Paoli, Amanda, Anderson, Bethany M, Edgington-Mitchell, Laura E, Charman, Susan A, Creek, Darren J
Published in PLoS pathogens (01.06.2020)
Published in PLoS pathogens (01.06.2020)
Get full text
Journal Article
A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum–infected red blood cell proteome
Siddiqui, Ghizal, De Paoli, Amanda, MacRaild, Christopher A, Sexton, Anna E, Boulet, Coralie, Shah, Anup D, Batty, Mitchell B, Schittenhelm, Ralf B, Carvalho, Teresa G, Creek, Darren J
Published in Gigascience (07.03.2022)
Published in Gigascience (07.03.2022)
Get full text
Journal Article
Ultraviolet/Visible and Near-Infrared Dual Spectroscopic Method for Detection and Quantification of Low-Level Malaria Parasitemia in Whole Blood
Adegoke, John A, De Paoli, Amanda, Afara, Isaac O, Kochan, Kamila, Creek, Darren J, Heraud, Philip, Wood, Bayden R
Published in Analytical chemistry (Washington) (05.10.2021)
Published in Analytical chemistry (Washington) (05.10.2021)
Get full text
Journal Article
Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase‐5 in human monocytes
Bitto, Natalie J, Baker, Paul J, Dowling, Jennifer K, Wray‐McCann, Georgie, De Paoli, Amanda, Tran, Le Son, Leung, Pak Ling, Stacey, Katryn J, Mansell, Ashley, Masters, Seth L, Ferrero, Richard L
Published in Immunology and cell biology (01.11.2018)
Published in Immunology and cell biology (01.11.2018)
Get full text
Journal Article
Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum
Birrell, Geoffrey W., Challis, Matthew P., De Paoli, Amanda, Anderson, Dovile, Devine, Shane M., Heffernan, Gavin D., Jacobus, David P., Edstein, Michael D., Siddiqui, Ghizal, Creek, Darren J.
Published in Molecular & cellular proteomics (01.02.2020)
Published in Molecular & cellular proteomics (01.02.2020)
Get full text
Journal Article
Discovery and development of 2-aminobenzimidazoles as potent antimalarials
Devine, Shane M., Challis, Matthew P., Kigotho, Jomo K., Siddiqui, Ghizal, De Paoli, Amanda, MacRaild, Christopher A., Avery, Vicky M., Creek, Darren J., Norton, Raymond S., Scammells, Peter J.
Published in European journal of medicinal chemistry (05.10.2021)
Published in European journal of medicinal chemistry (05.10.2021)
Get full text
Journal Article
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
Priebbenow, Daniel L, Mathiew, Mitch, Shi, Da-Hua, Harjani, Jitendra R, Beveridge, Julia G, Chavchich, Marina, Edstein, Michael D, Duffy, Sandra, Avery, Vicky M, Jacobs, Robert T, Brand, Stephen, Shackleford, David M, Wang, Wen, Zhong, Longjin, Lee, Given, Tay, Erin, Barker, Helena, Crighton, Elly, White, Karen L, Charman, Susan A, De Paoli, Amanda, Creek, Darren J, Baell, Jonathan B
Published in Journal of medicinal chemistry (08.04.2021)
Published in Journal of medicinal chemistry (08.04.2021)
Get full text
Journal Article
NOD1 is required for Helicobacter pylori induction of IL‐33 responses in gastric epithelial cells
Tran, Le Son, Tran, Darren, De Paoli, Amanda, D'Costa, Kimberley, Creed, Sarah J., Ng, Garrett Z., Le, Lena, Sutton, Philip, Silke, J., Nachbur, U., Ferrero, Richard L.
Published in Cellular microbiology (01.05.2018)
Published in Cellular microbiology (01.05.2018)
Get full text
Journal Article
The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite
Ellis, Katherine M, Lucantoni, Leonardo, Chavchich, Marina, Abraham, Matthew, De Paoli, Amanda, Luth, Madeline R, Zeeman, Anne-Marie, Delves, Michael J, Terán, Fernando Sánchez-Román, Straschil, Ursula, Baum, Jake, Kocken, Clemens H M, Ralph, Stuart A, Winzeler, Elizabeth A, Avery, Vicky M, Edstein, Michael D, Baell, Jonathan B, Creek, Darren J
Published in Antimicrobial agents and chemotherapy (18.10.2021)
Published in Antimicrobial agents and chemotherapy (18.10.2021)
Get full text
Journal Article
Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells
Siddiqui, Ghizal, Giannangelo, Carlo, De Paoli, Amanda, Schuh, Anna Katharina, Heimsch, Kim C, Anderson, Dovile, Brown, Timothy G, MacRaild, Christopher A, Wu, Jianbo, Wang, Xiaofang, Dong, Yuxiang, Vennerstrom, Jonathan L, Becker, Katja, Creek, Darren J
Published in ACS infectious diseases (14.01.2022)
Published in ACS infectious diseases (14.01.2022)
Get full text
Journal Article
Complete genome sequence of Helicobacter pylori B128 7.13 and a single‐step method for the generation of unmarked mutations
Dawson, Emma M., Dunne, Karl A., Richardson, Emily J., Praszkier, Judyta, Alfawaz, Dana, Woelfel, Simon, De Paoli, Amanda, Chaudhry, Hassan, Henderson, Ian R., Ferrero, Richard L., Rossiter, Amanda E.
Published in Helicobacter (Cambridge, Mass.) (01.08.2019)
Published in Helicobacter (Cambridge, Mass.) (01.08.2019)
Get full text
Journal Article
Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum
Birrell, Geoffrey W, Challis, Matthew P, De Paoli, Amanda, Anderson, Dovile, Devine, Shane M, Heffernan, Gavin D, Jacobus, David P, Edstein, Michael D, Siddiqui, Ghizal, Creek, Darren J
Published in Molecular & cellular proteomics (01.02.2020)
Get full text
Published in Molecular & cellular proteomics (01.02.2020)
Journal Article
Peroxide antimalarial drugs target redox homeostasis in Plasmodium falciparum infected red blood cells
Siddiqui, Ghizal, Giannangelo, Carlo, De Paoli, Amanda E, Schuh, Anna Katharina, Heimsch, Kim, Anderson, Dovile, Brown, Timothy G, Macraild, Christopher A, Wu, Jianbo, Wang, Xiaofang, Dong, Yuxiang, Vennerstrom, Jonathan L, Becker, Katja, Creek, Darren J
Published in bioRxiv (11.09.2021)
Published in bioRxiv (11.09.2021)
Get full text
Paper
NOD1 mediates non-canonical inflammasome processing of interleukin-18 in epithelial cells to Helicobacter pylori infection
Le Son Tran, Le, Ying, D'costa, Kimberley, Wray-Mccann, Georgie, Kerr, Genevieve, Le, Lena, Allison, Cody C, Ferrand, Jonathan, Chaudhry, Hassan, Emery, Jack, De Paoli, Amanda, Creed, Sarah, Kaparakis-Liaskos, Maria, Como, Julia, Dowling, Jennifer, Johanesen, Priscilla A, Kufer, Thomas A, Pedersen, John S, Mansell, Ashley, Philpott, Dana J, Elgass, Kirstin, Abud, Helen E, Nachbur, Ueli, Croker, Ben A, Masters, Seth L, Ferrero, Richard Louis
Published in bioRxiv (24.03.2019)
Published in bioRxiv (24.03.2019)
Get full text
Paper