Dual Plasmepsin-Targeting Antimalarial Agents Disrupt Multiple Stages of the Malaria Parasite Life Cycle
Favuzza, Paola, de Lera Ruiz, Manuel, Thompson, Jennifer K., Triglia, Tony, Ngo, Anna, Steel, Ryan W.J., Vavrek, Marissa, Christensen, Janni, Healer, Julie, Boyce, Christopher, Guo, Zhuyan, Hu, Mengwei, Khan, Tanweer, Murgolo, Nicholas, Zhao, Lianyun, Penington, Jocelyn Sietsma, Reaksudsan, Kitsanapong, Jarman, Kate, Dietrich, Melanie H., Richardson, Lachlan, Guo, Kai-Yuan, Lopaticki, Sash, Tham, Wai-Hong, Rottmann, Matthias, Papenfuss, Tony, Robbins, Jonathan A., Boddey, Justin A., Sleebs, Brad E., Sabroux, Hélène Jousset, McCauley, John A., Olsen, David B., Cowman, Alan F.
Published in Cell host & microbe (08.04.2020)
Published in Cell host & microbe (08.04.2020)
Get full text
Journal Article
Histamine H3 Receptor as a Drug Discovery Target
Berlin, Michael, Boyce, Christopher W, de Lera Ruiz, Manuel
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
Get full text
Journal Article
Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption
Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.
Published in ChemMedChem (01.02.2015)
Published in ChemMedChem (01.02.2015)
Get full text
Journal Article
Histamine H 3 Receptor as a Drug Discovery Target
Berlin, Michael, Boyce, Christopher W., de Lera Ruiz, Manuel
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
Get full text
Journal Article
Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax
Hodder, Anthony N, Christensen, Janni, Scally, Stephen, Triglia, Tony, Ngo, Anna, Birkinshaw, Richard W, Bailey, Brodie, Favuzza, Paola, Dietrich, Melanie H, Tham, Wai-Hong, Czabotar, Peter E, Lowes, Kym, Guo, Zhuyan, Murgolo, Nicholas, Lera Ruiz, Manuel de, McCauley, John A, Sleebs, Brad E, Olsen, David, Cowman, Alan F
Published in Structure (London) (07.07.2022)
Published in Structure (London) (07.07.2022)
Get full text
Journal Article
Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3‑Fluoro-4-aminopiperidine
Molinaro, Carmela, Phillips, Eric M, Xiang, Bangping, Milczek, Erika, Shevlin, Michael, Balsells, Jaume, Ceglia, Scott, Chen, Jiahui, Chen, Lu, Chen, Qinghao, Fei, Zhongbo, Hoerrner, Scott, Qi, Ji, de Lera Ruiz, Manuel, Tan, Lushi, Wan, Baoqiang, Yin, Jingjun
Published in Journal of organic chemistry (21.06.2019)
Published in Journal of organic chemistry (21.06.2019)
Get full text
Journal Article
The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria
de Lera Ruiz, Manuel, Favuzza, Paola, Guo, Zhuyan, Zhao, Lianyun, Hu, Bin, Lei, Zhiyu, Zhan, Dongmei, Murgolo, Nicholas, Boyce, Christopher W., Vavrek, Marissa, Thompson, Jennifer, Ngo, Anna, Jarman, Kate E., Robbins, Johnathan, Boddey, Justin, Sleebs, Brad E., Lowes, Kym N., Cowman, Alan F., Olsen, David B., McCauley, John A.
Published in ACS medicinal chemistry letters (10.11.2022)
Published in ACS medicinal chemistry letters (10.11.2022)
Get full text
Journal Article
Careful Navigation of the Crystallographic Landscape of MK-8970: A Racemic Acetal Carbonate Prodrug of Raltegravir
Tsou, Nancy, Shultz, C. Scott, Andreani, Teresa, Ball, Richard G, Brunskill, Andrew, Balsells, Jaume, Cohen, Ryan D, DaSilva, Jimmy, Li, Jing, Reamer, Robert A, de Lera Ruiz, Manuel, Variankaval, Narayan, Varsolona, Richard J, Yasuda, Nobuyoshi, York, Gregory
Published in Organic process research & development (18.12.2015)
Published in Organic process research & development (18.12.2015)
Get full text
Journal Article
Exploration of conjugate addition routes to advanced tricyclic components of mangicol A
Pichlmair, Stefan, de Lera Ruiz, Manuel, Vilotijevic, Ivan, Paquette, Leo A.
Published in Tetrahedron (12.06.2006)
Published in Tetrahedron (12.06.2006)
Get full text
Journal Article
Adenosine A2A Receptor as a Drug Discovery Target
de Lera Ruiz, Manuel, Lim, Yeon-Hee, Zheng, Junying
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
Get full text
Journal Article
Invention of MK-7845, a SARS-CoV‑2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic
Shurtleff, Valerie W., Layton, Mark E., Parish, Craig A., Perkins, James J., Schreier, John D., Wang, Yunyi, Adam, Gregory C., Alvarez, Nadine, Bahmanjah, Soheila, Bahnck-Teets, Carolyn M., Boyce, Christopher W., Burlein, Christine, Cabalu, Tamara D., Campbell, Brian T., Carroll, Steven S., Chang, Wonsuk, de Lera Ruiz, Manuel, Dolgov, Enriko, Fay, John F., Fox, Nicholas G., Goh, Shih Lin, Hartingh, Timothy J., Hurzy, Danielle M., Kelly, Michael J., Klein, Daniel J., Klingler, Franca-Maria, Krishnamurthy, Harini, Kudalkar, Shalley, Mayhood, Todd W., McKenna, Philip M., Murray, Edward M., Nahas, Debbie, Nawrat, Christopher C., Park, Steven, Qian, Dongming, Roecker, Anthony J., Sharma, Vijeta, Shipe, William D., Su, Jing, Taggart, Robert V., Truong, Quang, Wu, Yin, Zhou, Xiaoyan, Zhuang, Ningning, Perlin, David S., Olsen, David B., Howe, John A., McCauley, John A.
Published in Journal of medicinal chemistry (14.03.2024)
Published in Journal of medicinal chemistry (14.03.2024)
Get full text
Journal Article
Adenosine A 2A Receptor as a Drug Discovery Target
de Lera Ruiz, Manuel, Lim, Yeon-Hee, Zheng, Junying
Published in Journal of medicinal chemistry (08.05.2014)
Published in Journal of medicinal chemistry (08.05.2014)
Get full text
Journal Article
Bicyclic and tricyclic heterocycle derivatives as histamine H-3 receptor antagonists for the treatment of obesity
Ruiz, Manuel de Lera, Zheng, Junying, Berlin, Michael Y., McCormick, Kevin D., Aslanian, Robert G., West, Robert, Hwa, Joyce, Lachowicz, Jean, van Heek, Margaret
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Get full text
Journal Article
Bicyclic and tricyclic heterocycle derivatives as histamine H3 receptor antagonists for the treatment of obesity
de Lera Ruiz, Manuel, Zheng, Junying, Berlin, Michael Y., McCormick, Kevin D., Aslanian, Robert G., West, Robert, Hwa, Joyce, Lachowicz, Jean, van Heek, Margaret
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Get full text
Journal Article
Evaluation of possible intramolecular [4+2] cycloaddition routes for assembling the central tetracyclic core of the potent marine antiinflammatory agent mangicol A
Pichlmair, Stefan, de Lera Ruiz, Manuel, Basu, Kallol, Paquette, Leo A.
Published in Tetrahedron (29.05.2006)
Published in Tetrahedron (29.05.2006)
Get full text
Journal Article
Evaluation of possible intramolecular [4+2] cycloaddition routes for assembling the central tetracyclic core of the potent marine antfinflammatory agent mangicol A
Pichlmair, Stefan, de Lera Ruiz, Manuel, Basu, Kallol, Paquette, Leo A.
Published in Tetrahedron (29.05.2006)
Published in Tetrahedron (29.05.2006)
Get full text
Journal Article
Cover Picture: Discovery of MK-8970: An Acetal Carbonate Prodrug of Raltegravir with Enhanced Colonic Absorption (ChemMedChem 2/2015)
Walji, Abbas M., Sanchez, Rosa I., Clas, Sophie-Dorothee, Nofsinger, Rebecca, de Lera Ruiz, Manuel, Li, Jing, Bennet, Amrithraj, John, Christopher, Bennett, David Jonathan, Sanders, John M., Di Marco, Christina N., Kim, Somang Hope, Balsells, Jaume, Ceglia, Scott S., Dang, Qun, Manser, Kimberly, Nissley, Becky, Wai, John S., Hafey, Michael, Wang, Junying, Chessen, Gene, Templeton, Allen, Higgins, John, Smith, Ronald, Wu, Yunhui, Grobler, Jay, Coleman, Paul J.
Published in ChemMedChem (01.02.2015)
Published in ChemMedChem (01.02.2015)
Get full text
Journal Article