IRDiRC Drug Repurposing Guidebook: making better use of existing drugs to tackle rare diseases
Hechtelt Jonker, Anneliene, Day, Simon, Gabaldo, Michela, Stone, Heather, de Kort, Martin, O’Connor, Daniel J., Pasmooij, Anna Maria Gerdina
Published in Nature reviews. Drug discovery (01.12.2023)
Published in Nature reviews. Drug discovery (01.12.2023)
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Journal Article
Drug repurposing for rare: progress and opportunities for the rare disease community
Jonker, Anneliene Hechtelt, O'Connor, Daniel, Cavaller-Bellaubi, Maria, Fetro, Christine, Gogou, Maria, 't Hoen, Peter A C, de Kort, Martin, Stone, Heather, Valentine, Nivedita, Pasmooij, Anna Maria Gerdina
Published in Frontiers in medicine (2024)
Published in Frontiers in medicine (2024)
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Journal Article
Conjugation of ATIII-Binding Pentasaccharides to Extend the Half-Life of Proteins: Long-Acting Insulin
de Kort, Martin, Gianotten, Bas, Wisse, Jeffry A. J., Bos, Ebo S., Eppink, Michel H. M., Mattaar, Ellen, Vogel, Gerard M. T., Dokter, Wim H. A., Honing, Maarten, Vonsovic, Stanislava, Smit, Martin-Jan, Wijkmans, Jac C. H. M., van Boeckel, Constant A. A.
Published in ChemMedChem (18.08.2008)
Published in ChemMedChem (18.08.2008)
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Journal Article
Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type 2 Diabetes
Irwin, Nigel, Patterson, Steven, de Kort, Martin, Moffett, R. Charlotte, Wisse, Jeffry A. J., Dokter, Wim H. A., Bos, Ebo S., Miltenburg, André M. M., Flatt, Peter R.
Published in ChemMedChem (01.08.2015)
Published in ChemMedChem (01.08.2015)
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Journal Article
From heparin to EP217609: the long way to a new pentasaccharide-based neutralisable anticoagulant with an unprecedented pharmacological profile
Petitou, Maurice, Nancy-Portebois, Vanessa, Dubreucq, Guy, Motte, Vincent, Meuleman, Dick, de Kort, Martin, van Boeckel, Constant A A, Vogel, Gerard M T, Wisse, Jeffry A J
Published in Thrombosis and haemostasis (01.11.2009)
Published in Thrombosis and haemostasis (01.11.2009)
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Half‐life prolongation of therapeutic proteins by conjugation to ATIII‐binding pentasaccharides: a first‐in‐human study of CarboCarrier® insulin
Miltenburg, André M. M., Prohn, Marita, Kuijk, Jacqueline H. M., Tiessen, Renger G., Kort, Martin, Berg, Rob J. W.
Published in British journal of clinical pharmacology (01.05.2013)
Published in British journal of clinical pharmacology (01.05.2013)
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Journal Article
Spirophostins: Conformationally Restricted Analogues of Adenophostin A
de Kort, Martin, Regenbogen, Anouk D., Valentijn, A. Rob P. M., Challiss, R. A. John, Iwata, Yoriko, Miyamoto, Shuichi, van der Marel, Gijs A., van Boom, Jacques H.
Published in Chemistry : a European journal (04.08.2000)
Published in Chemistry : a European journal (04.08.2000)
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Journal Article
Synthetic heparin derivatives as new anticoagulant drugs
de Kort, Martin, Buijsman, Rogier C., van Boeckel, Constant A.A.
Published in Drug discovery today (01.06.2005)
Published in Drug discovery today (01.06.2005)
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Journal Article
Half‐life prolongation of therapeutic proteins by conjugation to ATIII ‐binding pentasaccharides: a first‐in‐human study of C arbo C arrier ® insulin
Miltenburg, André M. M., Prohn, Marita, van Kuijk, Jacqueline H. M., Tiessen, Renger G., de Kort, Martin, Berg, Rob J. W.
Published in British journal of clinical pharmacology (01.05.2013)
Published in British journal of clinical pharmacology (01.05.2013)
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Journal Article
Synthesis and Evaluation of a Series of Long-Acting Glucagon-Like Peptide-1 (GLP-1) Pentasaccharide Conjugates for the Treatment of Type2 Diabetes
Irwin, Nigel, Patterson, Steven, deKort, Martin, Moffett, R Charlotte, Wisse, Jeffry A J, Dokter, Wim H A, Bos, Ebo S, Miltenburg, André M M, Flatt, Peter R
Published in ChemMedChem (01.08.2015)
Published in ChemMedChem (01.08.2015)
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Journal Article
Development of a novel ionic support and its application in the ionic liquid phase assisted synthesis of a potent antithrombotic
de Kort, Martin, Tuin, Adriaan W., Kuiper, Suzanne, Overkleeft, Hermen S., van der Marel, Gijs A., Buijsman, Rogier C.
Published in Tetrahedron letters (01.03.2004)
Published in Tetrahedron letters (01.03.2004)
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Journal Article
modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans
Cross, M, Kieft, R, Sabatini, R, Wilm, M, Kort, M. de, Marel, G.A. van der, Boom, J.H. van, Leeuwen, F. van, Borst, P
Published in The EMBO journal (15.11.1999)
Published in The EMBO journal (15.11.1999)
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Journal Article
Chemical and Enzymatic Synthesis of DNA Fragments Containing 5-(β-D-Glucopyranosyloxymethyl)-2′-deoxycytidine − a Modified Nucleoside in T4 Phage DNA
de Kort, Martin, de Visser, Peter C., Kurzeck, Jürgen, Meeuwenoord, Nico J., van der Marel, Gijs A., Rüger, Wolfgang, van Boom, Jacques H.
Published in European journal of organic chemistry (01.06.2001)
Published in European journal of organic chemistry (01.06.2001)
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Journal Article
Synthesis of Oligodeoxynucleotides Containing 5-(β-D-Glucopyranosyloxymethyl)-2′-deoxyuridine, a Modified Nucleoside in the DNA of Trypanosoma Brucei
de Kort, Martin, Ebrahimi, Edwin, Wijsman, Eric R., van der Marel, Gijs A., van Boom, Jacques H.
Published in European journal of organic chemistry (01.09.1999)
Published in European journal of organic chemistry (01.09.1999)
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Journal Article
Synthesis and Biological Evaluation of Cyclophostin: A 5′,6″-Tethered Analog of Adenophostin A
de Kort, Martin, Regenbogen, Anouk D., Overkleeft, Herman S., John Challiss, R.A., Iwata, Yoriko, Miyamoto, Shuichi, van der Marel, Gijs A., van Boom, Jacques H.
Published in Tetrahedron (04.08.2000)
Published in Tetrahedron (04.08.2000)
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Journal Article
Synthesis of Photoaffinity Derivatives of Adenophostin A
de Kort, Martin, Luijendijk, Jaco, van der Marel, Gijs A., van Boom, Jacques H.
Published in European journal of organic chemistry (01.09.2000)
Published in European journal of organic chemistry (01.09.2000)
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Journal Article
Synthesis of Oligodeoxynucleotides Containing 5-(β-D-Glucopyranosyloxymethyl)-2′-deoxyuridine, a Modified Nucleoside in the DNA ofTrypanosoma Brucei
de Kort, Martin, Ebrahimi, Edwin, Wijsman, Eric R., van der Marel, Gijs A., van Boom, Jacques H.
Published in European journal of organic chemistry (01.09.1999)
Published in European journal of organic chemistry (01.09.1999)
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Journal Article
The modified base J is the target for a novelDNA-binding protein in kinetoplastid protozoans
Cross, Mike, Kieft, Rudo, Sabatini, Robert, Wilm, Matthias, de Kort, Martin, van der Marel, Gijs A., van Boom, Jacques H., van Leeuwen, Fred, Borst, Piet
Published in The EMBO journal (15.11.1999)
Published in The EMBO journal (15.11.1999)
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Journal Article