β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease
Thathiah, Amantha, Horré, Katrien, Snellinx, An, Vandewyer, Elke, Huang, Yunhong, Ciesielska, Marta, De Kloe, Gerdien, Munck, Sebastian, De Strooper, Bart
Published in Nature medicine (01.01.2013)
Published in Nature medicine (01.01.2013)
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Journal Article
Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays
Heus, Ferry, Giera, Martin, de Kloe, Gerdien E, van Iperen, Dick, Buijs, Joost, Nahar, Tariq T, Smit, August B, Lingeman, Henk, de Esch, Iwan J. P, Niessen, Wilfried M. A, Irth, Hubertus, Kool, Jeroen
Published in Analytical and bioanalytical chemistry (01.12.2010)
Published in Analytical and bioanalytical chemistry (01.12.2010)
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Journal Article
Transforming fragments into candidates: small becomes big in medicinal chemistry
de Kloe, Gerdien E., Bailey, David, Leurs, Rob, de Esch, Iwan J.P.
Published in Drug discovery today (01.07.2009)
Published in Drug discovery today (01.07.2009)
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Journal Article
Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein
Stornaiuolo, Mariano, De Kloe, Gerdien E., Rucktooa, Prakash, Fish, Alexander, van Elk, René, Edink, Ewald S., Bertrand, Daniel, Smit, August B., de Esch, Iwan J. P., Sixma, Titia K.
Published in Nature communications (21.05.2013)
Published in Nature communications (21.05.2013)
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Journal Article
Small and colorful stones make beautiful mosaics: fragment-based chemogenomics
de Graaf, Chris, Vischer, Henry F., de Kloe, Gerdien E., Kooistra, Albert J., Nijmeijer, Saskia, Kuijer, Martien, Verheij, Mark H.P., England, Paul J., van Muijlwijk-Koezen, Jacqueline E., Leurs, Rob, de Esch, Iwan J.P.
Published in Drug discovery today (01.04.2013)
Published in Drug discovery today (01.04.2013)
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Journal Article
Online Fluorescence Enhancement Assay for the Acetylcholine Binding Protein with Parallel Mass Spectrometric Identification
Kool, Jeroen, de Kloe, Gerdien E, Bruyneel, Ben, de Vlieger, Jon S, Retra, Kim, Wijtmans, Maikel, van Elk, Rene, Smit, August B, Leurs, Rob, Lingeman, Henk, de Esch, Iwan J.P, Irth, Hubertus
Published in Journal of medicinal chemistry (24.06.2010)
Published in Journal of medicinal chemistry (24.06.2010)
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Journal Article
Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor α7 Ligands
de Kloe, Gerdien E, Retra, Kim, Geitmann, Matthis, Källblad, Per, Nahar, Tariq, van Elk, René, Smit, August B, van Muijlwijk-Koezen, Jacqueline E, Leurs, Rob, Irth, Hubertus, Danielson, U. Helena, de Esch, Iwan J. P
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Journal Article
Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine-Binding Protein
Geitmann, Matthis, Retra, Kim, de Kloe, Gerdien E, Homan, Evert, Smit, August B, de Esch, Iwan J. P, Danielson, U. Helena
Published in Biochemistry (Easton) (21.09.2010)
Published in Biochemistry (Easton) (21.09.2010)
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Journal Article
Nanofractionation Spotter Technology for Rapid Contactless and High-Resolution Deposition of LC Eluent for Further Off-Line Analysis
Kool, Jeroen, de Kloe, Gerdien, Denker, Arnoud D, van Altena, Klaas, Smoluch, Marek, van Iperen, Dick, Nahar, Tariq T, Limburg, Rob J, Niessen, Wilfried M. A, Lingeman, Henk, Leurs, Rob, de Esch, Iwan J. P, Smit, August B, Irth, Hubertus
Published in Analytical chemistry (Washington) (01.01.2011)
Published in Analytical chemistry (Washington) (01.01.2011)
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Journal Article
Small molecules that inhibit Notch signaling
De Kloe, Gerdien E, De Strooper, Bart
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2014)
Published in Methods in molecular biology (Clifton, N.J.) (01.01.2014)
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Journal Article
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A
Verheij, Mark H.P., de Graaf, Chris, de Kloe, Gerdien E., Nijmeijer, Saskia, Vischer, Henry F., Smits, Rogier A., Zuiderveld, Obbe P., Hulscher, Saskia, Silvestri, Linda, Thompson, Andrew J., van Muijlwijk-Koezen, Jacqueline E., Lummis, Sarah C.R., Leurs, Rob, de Esch, Iwan J.P.
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
Published in Bioorganic & medicinal chemistry letters (15.09.2011)
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Journal Article
Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H-4 Receptor Affinity and Subtly Govern H-4/H-3 Subtype Selectivity
Wijtmans, Maikel, de Graaf, Chris, de Kloe, Gerdien, Istyastono, Enade P., Smit, Judith, Lim, Herman, Boonnak, Ratchanok, Nijmeijer, Saskia, Smits, Rogier A., Jongejan, Aldo, Zuiderveld, Obbe, de Esch, Iwan J. P., Leurs, Rob
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Journal Article
[beta]-arrestin 2 regulates A[beta] generation and [gamma]-secretase activity in Alzheimer's disease
Thathiah, Amantha, Horré, Katrien, Snellinx, An, Vandewyer, Elke, Huang, Yunhong, Ciesielska, Marta, De Kloe, Gerdien, Munck, Sebastian, De Strooper, Bart
Published in Nature medicine (01.01.2013)
Published in Nature medicine (01.01.2013)
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Journal Article
Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor alpha 7 Ligands
de Kloe, Gerdien E., Retra, Kim, Geitmann, Matthis, Kallblad, Per, Nahar, Tariq, van Elk, Rene, Smit, August B., van Muijlwijk-Koezen, Jacqueline E., Leurs, Rob, Irth, Hubertus, Danielson, U. Helena, de Esch, Iwan J. P.
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Journal Article
O3–07–01: Beta‐arrestin 2 regulates GPCR dysfunction in Alzheimer's disease
Thathiah, Amantha, Horre, Katrien, Snellinx, An, Vandewyer, Elke, Huang, Yunhong, De Kloe, Gerdien, Munck, Sebastian, De Strooper, Bart
Published in Alzheimer's & dementia (01.07.2013)
Published in Alzheimer's & dementia (01.07.2013)
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Journal Article
Beta-arrestin 2 regulates GPCR dysfunction in Alzheimer's disease
Thathiah, Amantha, Horre, Katrien, Snellinx, An, Vandewyer, Elke, Huang, Yunhong, De Kloe, Gerdien, Munck, Sebastian, De Strooper, Bart
Published in Alzheimer's & dementia (01.07.2013)
Published in Alzheimer's & dementia (01.07.2013)
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Journal Article
β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease
Thathiah, Amantha, Horre, Katrien, Snellinx, An, Vandewyer, Elke, Huang, Yunhong, Ciesielska, Marta, De Kloe, Gerdien, Munck, Sebastian, De Strooper, Bart
Published in Molecular neurodegeneration (13.09.2013)
Published in Molecular neurodegeneration (13.09.2013)
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Journal Article
Triazole Ligands Reveal Distinct Molecular Features That Induce Histamine H4 Receptor Affinity and Subtly Govern H4/H3 Subtype Selectivity
Wijtmans, Maikel, de Graaf, Chris, de Kloe, Gerdien, Istyastono, Enade P, Smit, Judith, Lim, Herman, Boonnak, Ratchanok, Nijmeijer, Saskia, Smits, Rogier A, Jongejan, Aldo, Zuiderveld, Obbe, de Esch, Iwan J. P, Leurs, Rob
Published in Journal of medicinal chemistry (24.03.2011)
Published in Journal of medicinal chemistry (24.03.2011)
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Journal Article
High-Resolution Bioactivity Profiling of Mixtures toward the Acetylcholine Binding Protein Using a Nanofractionation Spotter Technology
Kool, Jeroen, Heus, Ferry, de Kloe, Gerdien, Lingeman, Henk, Smit, August B., Leurs, Rob, Edink, Ewald, De Esch, Iwan J.P., Irth, Hubertus, Niessen, Wilfried M.A.
Published in Journal of biomolecular screening (01.09.2011)
Published in Journal of biomolecular screening (01.09.2011)
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