Neutralization escape of emerging subvariants XBB.1.5/1.9.1 and XBB.2.3 from current therapeutic monoclonal antibodies
Chye, De Hoe, Chew, Charmaine W Y, Yeo, He Ping, Tambyah, Paul A, Young, Barnaby E, Tan, Gladys G Y, Tan, Boon Huan, Vasoo, Shawn, Chan, Conrad E Z
Published in Journal of medical virology (01.09.2023)
Published in Journal of medical virology (01.09.2023)
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The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies
Chan, Conrad En-Zuo, Ng, Ching-Ging, Lim, Angeline Pei-Chew, Seah, Shirley Lay-Kheng, Chye, De-Hoe, Wong, Steven Ka-Khuen, Lim, Jie-Hui, Lim, Vanessa Zi-Yun, Lai, Soak-Kuan, Wong, Pui-San, Leong, Kok-Mun, Liu, Yi-Chun, Sugrue, Richard J., Tan, Boon-Huan
Published in Journal of virology (13.07.2022)
Published in Journal of virology (13.07.2022)
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IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development
Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh T. L., Le, Nguyen, Chan, Conrad E. Z., Desai, Rishi, Ding, Xianting, Hanson, Brendon J., Chow, Edward Kai‐Hua, Ho, Dean
Published in Bioengineering & Translational Medicine (01.01.2021)
Published in Bioengineering & Translational Medicine (01.01.2021)
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The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens
Blasiak, Agata, Truong, Anh T L, Remus, Alexandria, Hooi, Lissa, Seah, Shirley Gek Kheng, Wang, Peter, Chye, De Hoe, Lim, Angeline Pei Chiew, Ng, Kim Tien, Teo, Swee Teng, Tan, Yee-Joo, Allen, David Michael, Chai, Louis Yi Ann, Chng, Wee Joo, Lin, Raymond T P, Lye, David C B, Wong, John Eu-Li, Tan, Gek-Yen Gladys, Chan, Conrad En Zuo, Chow, Edward Kai-Hua, Ho, Dean
Published in NPJ digital medicine (30.06.2022)
Published in NPJ digital medicine (30.06.2022)
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Enhanced neutralizing antibody titers and Th1 polarization from a novel Escherichia coli derived pandemic influenza vaccine
Skibinski, David A G, Hanson, Brendon J, Lin, Yufang, von Messling, Veronika, Jegerlehner, Andrea, Tee, Jason Boon Sern, Chye, De Hoe, Wong, Steven K K, Ng, Amanda A P, Lee, Hui Yin, Au, Bijin, Lee, Bernett T K, Santoso, Lucia, Poidinger, Michael, Fairhurst, Anna-Marie, Matter, Alex, Bachmann, Martin F, Saudan, Philippe, Connolly, John E
Published in PloS one (18.10.2013)
Published in PloS one (18.10.2013)
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IDentif . AI : Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development
Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh T. L., Le, Nguyen, Chan, Conrad E. Z., Desai, Rishi, Ding, Xianting, Hanson, Brendon J., Chow, Edward Kai‐Hua, Ho, Dean
Published in Bioengineering & translational medicine (01.01.2021)
Published in Bioengineering & translational medicine (01.01.2021)
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
Chan, Conrad E. Z, Seah, Shirley G. K, Chye, De Hoe, Massey, Shane, Torres, Maricela, Lim, Angeline P. C, Wong, Steven K. K, Neo, Jacklyn J. Y, Wong, Pui San, Lim, Jie Hui, Loh, Gary S. L, Wang, Dongling, Boyd-Kirkup, Jerome D, Guan, Siyu, Thakkar, Dipti, Teo, Guo Hui, Purushotorman, Kiren, Hutchinson, Paul E, Young, Barnaby E, Low, Jenny G, MacAry, Paul A, Hentze, Hannes, Prativadibhayankara, Venkateshan S, Ethirajulu, Kantharaj, Comer, Jason E, Tseng, Chien-Te K, Barrett, Alan D. T, Ingram, Piers J, Brasel, Trevor, Hanson, Brendon John
Published in PloS one (23.06.2021)
Published in PloS one (23.06.2021)
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IDentif.AI-Omicron: Harnessing an AI-Derived and Disease-Agnostic Platform to Pinpoint Combinatorial Therapies for Clinically Actionable Anti-SARS-CoV‑2 Intervention
Blasiak, Agata, Truong, Anh T. L., Wang, Peter, Hooi, Lissa, Chye, De Hoe, Tan, Shi-Bei, You, Kui, Remus, Alexandria, Allen, David Michael, Chai, Louis Yi Ann, Chan, Conrad E.Z., Lye, David C. B., Tan, Gek-Yen G., Seah, Shirley G. K., Chow, Edward Kai-Hua, Ho, Dean
Published in ACS nano (27.09.2022)
Published in ACS nano (27.09.2022)
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First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults
Prativadibhayankaram, Venkateshan S., Lee, Lawrence Soon-U, Lye, David, Xiaoying, Xu, Nellore, Ranjani, Pendharkar, Vishal, Hentze, Hannes, Guan, Siyu, Ayers, Benjamin J., Seah, Shirley G. K., Chye, De Hoe, Talib, Najwa S. N., Kaliaperumal, Nivashini, Ong, Wei Yee, Wong, Zi Xin, Au, Veonice B., Alok, Anshula, Connolly, John E., Boyd-Kirkup, Jerome D., Ingram, Piers J., Hanson, Brendon J., Ethirajulu, Kantharaj, O’Connell, Damian, Chan, Conrad E. Z.
Published in Infectious diseases and therapy (01.10.2022)
Published in Infectious diseases and therapy (01.10.2022)
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Enhanced Neutralizing Antibody Titers and Th1 Polarization from a Novel Escherichia coli Derived Pandemic Influenza Vaccine: e76571
Skibinski, David AG, Hanson, Brendon J, Lin, Yufang, Messling, Veronika von, Jegerlehner, Andrea, Tee, Jason BoonSern, Chye, De Hoe, Wong, Steven KK, Ng, Amanda AP, Lee, Hui Yin
Published in PloS one (01.10.2013)
Published in PloS one (01.10.2013)
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The cellular characterisation of SARS-CoV-2 spike protein in virus-infected cells using Receptor Binding Domain-binding specific human monoclonal antibodies
Conrad En-Zuo Chan, Ng, Ching-Ging, Lim, Angeline P C, Seah, Shirley Gek-Kheng, De Hoe Chye, Wong, Steven K K, Jie-Hui, Lim, Vanessa Zi-Yun Lim, Lai, Soak Kuan, Wong, Pui-San, Kok-Mun Leong, Liu, Yichun, Sugrue, Richard, Boon Huan Tan
Published in bioRxiv (18.04.2022)
Published in bioRxiv (18.04.2022)
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The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
Conrad Ez Chan, Seah, Shirley Gk, De Hoe Chye, Massey, Shane, Torres, Maricela, Lim, Angeline Pc, Wong, Steven Kk, Neo, Jacklyn Jy, Pui San Wong, Jie Hui Lim, Loh, Gary Sl, Wang, Dong Ling, Boyd-Kirkup, Jerome D, Guan, Siyu, Thakkar, Dipti, Guo Hui Teo, Purushotorman, Kiren, Hutchinson, Paul E, Young, Barnaby E, Lye, David C, Low, Jenny G, Macary, Paul A, Hentze, Hannes, Prativadibhayankara, Venkateshan S, Ethirajulu, Kantharaj, Damian O’connell, Comer, Jason, Tseng, Chien-Te K, Barrett, Alan Dt, Ingram, Piers J, Brasel, Trevor, Hanson, Brendon J
Published in bioRxiv (26.10.2020)
Published in bioRxiv (26.10.2020)
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