Pharmacological characterization of a small‐molecule agonist for the chemokine receptor CXCR3
Scholten, DJ, Canals, M, Wijtmans, M, de Munnik, S, Nguyen, P, Verzijl, D, de Esch, IJP, Vischer, HF, Smit, MJ, Leurs, R
Published in British journal of pharmacology (01.06.2012)
Published in British journal of pharmacology (01.06.2012)
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Journal Article
The histamine H 3 receptor: from gene cloning to H 3 receptor drugs
Leurs, Rob, Bakker, Remko A, Timmerman, Henk, de Esch, Iwan J. P
Published in Nature reviews. Drug discovery (01.02.2005)
Published in Nature reviews. Drug discovery (01.02.2005)
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Journal Article
PSW-Designer: An Open-Source Computational Platform for the Design and Virtual Screening of Photopharmacological Ligands
Simon, Icaro A., Homan, Evert J., Wijtmans, Maikel, Sundström, Michael, Leurs, Rob, De Esch, Iwan J. P., Zarzycka, Barbara A.
Published in Journal of chemical information and modeling (13.11.2023)
Published in Journal of chemical information and modeling (13.11.2023)
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Journal Article
Chemical Insights in the Concept of Hybrid Drugs: The Antitumor Effect of Nitric Oxide-Donating Aspirin Involves A Quinone Methide but Not Nitric Oxide nor Aspirin
Hulsman, Niels, Medema, Jan Paul, Bos, Carina, Jongejan, Aldo, Leurs, Rob, Smit, Martine J, de Esch, Iwan J. P, Richel, Dick, Wijtmans, Maikel
Published in Journal of medicinal chemistry (17.05.2007)
Published in Journal of medicinal chemistry (17.05.2007)
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Journal Article
N-substituted piperidinyl alkyl imidazoles: Discovery of methimepip as a potent and selective histamine H-3 receptor agonist
Kitbunnadaj, R, Hashimoto, T, Poli, E, Zuiderveld, OP, Menozzi, A, Hidaka, R, de Esch, IJP, Bakker, RA, Menge, WMPB, Yamatodani, A, Coruzzi, G, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (24.03.2005)
Published in Journal of medicinal chemistry (24.03.2005)
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Journal Article
Synthesis and structure-activity relationships of conformationally constrained histamine H-3 receptor agonists
Kitbunnadaj, R, Zuiderveld, OP, De Esch, IJP, Vollinga, RC, Bakker, R, Lutz, M, Spek, AL, Cavoy, E, Deltent, MF, Menge, WMPB, Timmerman, H, Leurs, R
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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Journal Article
Synthesis and Structure−Activity Relationship of the First Nonpeptidergic Inverse Agonists for the Human Cytomegalovirus Encoded Chemokine Receptor US28
Hulshof, Janneke W, Casarosa, Paola, Menge, Wiro M. P. B, Kuusisto, Leena M. S, van der Goot, Henk, Smit, Martine J, de Esch, Iwan J. P, Leurs, Rob
Published in Journal of medicinal chemistry (06.10.2005)
Published in Journal of medicinal chemistry (06.10.2005)
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Journal Article
Histamine H sub(3) receptor antagonists reach out for the clinic
Celanire, S, Wijtmans, M, Talaga, P, Leurs, R, de Esch, IJP
Published in Drug discovery today (01.12.2005)
Published in Drug discovery today (01.12.2005)
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Journal Article
A chemical switch for the modulation of the functional activity of higher homologues of histamine on the human histamine H-3 receptor: Effect of various substitutions at the primary amino function
Govoni, M, Lim, HD, El-Atmioui, D, Menge, WMPB, Timmerman, H, Bakker, RA, Leurs, R, De Esch, IJP
Published in Journal of medicinal chemistry (20.04.2006)
Published in Journal of medicinal chemistry (20.04.2006)
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Journal Article
Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists
STORELLI, Stefania, VERDIJK, Pauline, VERZIJL, Dennis, TIMMERMAN, Henk, VAN DE STOLPE, Andrea C, TENSEN, Cornelis P, SMIT, Martine J, DE ESCH, Iwan J. P, LEURS, Rob
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article
New high affinity H 3 receptor agonists without a basic side chain
Kitbunnadaj, Ruengwit, Hoffmann, Marcel, Fratantoni, Silvina A., Bongers, Gerold, Bakker, Remko A., Wieland, Kerstin, Jilali, Ahmed el, De Esch, Iwan J.P., Menge, Wiro M.P.B., Timmerman, Henk, Leurs, Rob
Published in Bioorganic & medicinal chemistry (01.12.2005)
Published in Bioorganic & medicinal chemistry (01.12.2005)
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Journal Article
Development of a pharmacophore model for histamine H-3 receptor antagonists, using the newly developed molecular modeling program SLATE
De Esch, IJP, Mills, JEJ, Perkins, TDJ, Romeo, G, Hoffmann, M, Wieland, K, Leurs, R, Menge, WMPB, Nederkoorn, PHJ, Dean, PM, Timmerman, H
Published in Journal of medicinal chemistry (24.05.2001)
Published in Journal of medicinal chemistry (24.05.2001)
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Journal Article
A novel synthetic approach towards 2-guanidinomethyl-4(5)-sulfamoylimidazoles
Price, S, Bull, R, Cramp, S, Gardan, S, van den Heuvel, M, Neighbour, D, Osbourn, SE, de Esch, IJP, Buenemann, CL
Published in Tetrahedron letters (12.07.2004)
Published in Tetrahedron letters (12.07.2004)
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Journal Article
Characterization of the binding site of the histamine H-3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)cyclopropylamine
De Esch, IJP, Vollinga, RC, Goubitz, K, Schenk, H, Appelberg, U, Hacksell, U, Lemstra, S, Zuiderveld, OP, Hoffmann, M, Leurs, R, Menge, WMPB, Timmerman, H
Published in Journal of medicinal chemistry (08.04.1999)
Published in Journal of medicinal chemistry (08.04.1999)
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