Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors
Beyett, Tyler S., To, Ciric, Heppner, David E., Rana, Jaimin K., Schmoker, Anna M., Jang, Jaebong, De Clercq, Dries J. H., Gomez, Gabriel, Scott, David A., Gray, Nathanael S., Jänne, Pasi A., Eck, Michael J.
Published in Nature communications (09.05.2022)
Published in Nature communications (09.05.2022)
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Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor
Jang, Jaebong, Son, Jieun, Park, Eunyoung, Kosaka, Takayuki, Saxon, Jamie A., De Clercq, Dries J. H., Choi, Hwan Geun, Tanizaki, Junko, Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Published in Angewandte Chemie (International ed.) (03.09.2018)
Published in Angewandte Chemie (International ed.) (03.09.2018)
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Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations
Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Published in Angewandte Chemie International Edition (17.08.2020)
Published in Angewandte Chemie International Edition (17.08.2020)
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Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors
De Clercq, Dries J. H, Heppner, David E, To, Ciric, Jang, Jaebong, Park, Eunyoung, Yun, Cai-Hong, Mushajiang, Mierzhati, Shin, Bo Hee, Gero, Thomas W, Scott, David A, Jänne, Pasi A, Eck, Michael J, Gray, Nathanael S
Published in ACS medicinal chemistry letters (14.11.2019)
Published in ACS medicinal chemistry letters (14.11.2019)
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Chemical Dimerizers in Three-Hybrid Systems for Small Molecule–Target Protein Profiling
De Clercq, Dries J. H, Tavernier, Jan, Lievens, Sam, Van Calenbergh, Serge
Published in ACS chemical biology (19.08.2016)
Published in ACS chemical biology (19.08.2016)
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Proteome-scale Binary Interactomics in Human Cells
Lievens, Sam, Van der Heyden, José, Masschaele, Delphine, De Ceuninck, Leentje, Petta, Ioanna, Gupta, Surya, De Puysseleyr, Veronic, Vauthier, Virginie, Lemmens, Irma, De Clercq, Dries J.H., Defever, Dieter, Vanderroost, Nele, De Smet, Anne-Sophie, Eyckerman, Sven, Van Calenbergh, Serge, Martens, Lennart, De Bosscher, Karolien, Libert, Claude, Hill, David E., Vidal, Marc, Tavernier, Jan
Published in Molecular & cellular proteomics (01.12.2016)
Published in Molecular & cellular proteomics (01.12.2016)
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Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor
To, Ciric, Jang, Jaebong, Chen, Ting, Park, Eunyoung, Mushajiang, Mierzhati, De Clercq, Dries J H, Xu, Man, Wang, Stephen, Cameron, Michael D, Heppner, David E, Shin, Bo Hee, Gero, Thomas W, Yang, Annan, Dahlberg, Suzanne E, Wong, Kwok-Kin, Eck, Michael J, Gray, Nathanael S, Jänne, Pasi A
Published in Cancer discovery (01.07.2019)
Published in Cancer discovery (01.07.2019)
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Kinase Substrate Sensor (KISS), a Mammalian In Situ Protein Interaction Sensor
Lievens, Sam, Gerlo, Sarah, Lemmens, Irma, De Clercq, Dries J.H., Risseeuw, Martijn D.P., Vanderroost, Nele, De Smet, Anne-Sophie, Ruyssinck, Elien, Chevet, Eric, Van Calenbergh, Serge, Tavernier, Jan
Published in Molecular & cellular proteomics (01.12.2014)
Published in Molecular & cellular proteomics (01.12.2014)
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A "Clickable" MTX Reagent as a Practical Tool for Profiling Small-Molecule-Intracellular Target Interactions via MASPIT
Risseeuw, Martijn D. P., De Clercq, Dries J. H., Lievens, Sam, Hillaert, Ulrik, Sinnaeve, Davy, Van den Broeck, Freya, Martins, José C., Tavernier, Jan, Van Calenbergh, Serge
Published in ChemMedChem (01.03.2013)
Published in ChemMedChem (01.03.2013)
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Alternative Reagents for Methotrexate as Immobilizing Anchor Moieties in the Optimization of MASPIT: Synthesis and Biological Evaluation
De Clercq, Dries J. H., Risseeuw, Martijn D. P., Karalic, Izet, De Smet, Anne-Sophie, Defever, Dieter, Tavernier, Jan, Lievens, Sam, Van Calenbergh, Serge
Published in Chembiochem : a European journal of chemical biology (23.03.2015)
Published in Chembiochem : a European journal of chemical biology (23.03.2015)
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Journal Article
Mutant‐Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug‐Resistant Mutations
Jang, Jaebong, To, Ciric, De Clercq, Dries J. H., Park, Eunyoung, Ponthier, Charles M., Shin, Bo Hee, Mushajiang, Mierzhati, Nowak, Radosław P., Fischer, Eric S., Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Published in Angewandte Chemie (17.08.2020)
Published in Angewandte Chemie (17.08.2020)
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Journal Article
Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor
Jang, Jaebong, Son, Jieun, Park, Eunyoung, Kosaka, Takayuki, Saxon, Jamie A., De Clercq, Dries J. H., Choi, Hwan Geun, Tanizaki, Junko, Eck, Michael J., Jänne, Pasi A., Gray, Nathanael S.
Published in Angewandte Chemie (03.09.2018)
Published in Angewandte Chemie (03.09.2018)
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Journal Article
A "Clickable" MTX Reagent as a Practical Tool for Profiling Small-MoleculeIntracellular Target Interactions via MASPIT
Risseeuw, Martijn D. P., De Clercq, Dries J. H., Lievens, Sam, Hillaert, Ulrik, Sinnaeve, Davy, Van den Broeck, Freya, Martins, Jose C., Tavernier, Jan, Van Calenbergh, Serge
Published in ChemMedChem (01.03.2013)
Published in ChemMedChem (01.03.2013)
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