Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors
De Vreese, Rob, D'hooghe, Matthias
Published in European journal of medicinal chemistry (28.07.2017)
Published in European journal of medicinal chemistry (28.07.2017)
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Journal Article
Synthesis of Potent and Selective HDAC6 Inhibitors Bearing a Cyclohexane‐ or Cycloheptane‐Annulated 1,5‐Benzothiazepine Scaffold
De Vreese, Rob, Galle, Lisa, Depetter, Yves, Franceus, Jorick, Desmet, Tom, Van Hecke, Kristof, Benoy, Veronick, Van Den Bosch, Ludo, D'hooghe, Matthias
Published in Chemistry : a European journal (01.01.2017)
Published in Chemistry : a European journal (01.01.2017)
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Journal Article
Exploration of thiaheterocyclic hHDAC6 inhibitors as potential antiplasmodial agents
Vreese, Rob De, Kock, Carmen de, Smith, Peter J, Chibale, Kelly, D'hooghe, Matthias
Published in Future Medicinal Chemistry (01.03.2017)
Published in Future Medicinal Chemistry (01.03.2017)
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Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphates
Chen, Chao, Van der Borght, Jef, De Vreese, Rob, D'hooghe, Matthias, Soetaert, Wim, Desmet, Tom
Published in Chemical communications (Cambridge, England) (25.07.2014)
Published in Chemical communications (Cambridge, England) (25.07.2014)
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Converting bulk sugars into prebiotics: semi-rational design of a transglucosylase with controlled selectivity
Verhaeghe, Tom, De Winter, Karel, Berland, Magali, De Vreese, Rob, D'hooghe, Matthias, Offmann, Bernard, Desmet, Tom
Published in Chemical communications (Cambridge, England) (04.03.2016)
Published in Chemical communications (Cambridge, England) (04.03.2016)
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Journal Article
Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models
Depetter, Yves, Geurs, Silke, De Vreese, Rob, Goethals, Sophie, Vandoorn, Elien, Laevens, Alien, Steenbrugge, Jonas, Meyer, Evelyne, Tullio, Pascal, Bracke, Marc, D'hooghe, Matthias, De Wever, Olivier
Published in International journal of cancer (01.08.2019)
Published in International journal of cancer (01.08.2019)
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Synthesis and biological assessment of novel N-(hydroxy/methoxy)alkyl β-enaminone curcuminoids
Theppawong, Atiruj, De Vreese, Rob, Vannecke, Lore, Grootaert, Charlotte, Van Camp, John, D’hooghe, Matthias
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin A
De Vreese, Rob, Verhaeghe, Tom, Desmet, Tom, D'hooghe, Matthias
Published in Chemical communications (Cambridge, England) (08.05.2013)
Published in Chemical communications (Cambridge, England) (08.05.2013)
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Journal Article
Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors
De Vreese, Rob, Van Steen, Nicholas, Verhaeghe, Tom, Desmet, Tom, Bougarne, Nadia, De Bosscher, Karolien, Benoy, Veronick, Haeck, Wanda, Van Den Bosch, Ludo, D'hooghe, Matthias
Published in Chemical communications (Cambridge, England) (18.06.2015)
Published in Chemical communications (Cambridge, England) (18.06.2015)
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Synthesis of novel curcuminoids accommodating a central β-enaminone motif and their impact on cell growth and oxidative stress
De Vreese, Rob, Grootaert, Charlotte, D’hoore, Sander, Theppawong, Atiruj, Van Damme, Sam, Van Bogaert, Maarten, Van Camp, John, D’hooghe, Matthias
Published in European journal of medicinal chemistry (10.11.2016)
Published in European journal of medicinal chemistry (10.11.2016)
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Journal Article
Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors
De Vreese, Rob, Depetter, Yves, Verhaeghe, Tom, Desmet, Tom, Benoy, Veronick, Haeck, Wanda, Van Den Bosch, Ludo, D′hooghe, Matthias
Published in Organic & biomolecular chemistry (01.01.2016)
Published in Organic & biomolecular chemistry (01.01.2016)
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Converting bulk sugars into prebiotics: semi-rational design of a transglucosylase with controlled selectivityElectronic supplementary information (ESI) available: Mutagenesis, screening, ProSAR modelling, ligand docking, product analysis, production and downstream processing. See DOI: 10.1039/c5cc09940d
Verhaeghe, Tom, De Winter, Karel, Berland, Magali, De Vreese, Rob, D'hooghe, Matthias, Offmann, Bernard, Desmet, Tom
Year of Publication 23.02.2016
Year of Publication 23.02.2016
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Journal Article
Synthesis of bis-8-hydroxyquinolines via an imination or a Suzuki-Miyaura coupling approach
De Vreese, Rob, Muylaert, Koen, Maton, Cedric, Dereu, Lise, Taillieu, Frederique, Harth, Thomas, Van Deun, Rik, Vrielinck, Henk, Stevens, Christian V., D'hooghe, Matthias
Published in Tetrahedron letters (04.10.2017)
Published in Tetrahedron letters (04.10.2017)
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Journal Article
Potent and selective HDAC6 inhibitory activity of N-(4-hydroxycarbamoylbenzyl)-1,2,4,9-tetrahydro-3-thia-9-azafluorenes as novel sulfur analogues of Tubastatin AElectronic supplementary information (ESI) available: Synthetic procedures and spectral data of compounds 3, 4, 5, 6, 7 and 8, and bioassay results. See DOI: 10.1039/c3cc41422a
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Journal Article
Engineering the specificity of trehalose phosphorylase as a general strategy for the production of glycosyl phosphatesElectronic supplementary information (ESI) available: Methods and supporting data. See DOI: 10.1039/c4cc02202e
Chen, Chao, Van der Borght, Jef, De Vreese, Rob, D'hooghe, Matthias, Soetaert, Wim, Desmet, Tom
Year of Publication 24.06.2014
Year of Publication 24.06.2014
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Journal Article
Exploration of thiaheterocyclic
Vreese, Rob De, Kock, Carmen de, Smith, Peter J, Chibale, Kelly, D'hooghe, Matthias
Published in Future medicinal chemistry (01.03.2017)
Published in Future medicinal chemistry (01.03.2017)
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Journal Article
Exploration of Thiaheterocyclic H Hdac6 Inhibitors as Potential Antiplasmodial Agents
Vreese, Rob De, Kock, Carmen de, Smith, Peter J, Chibale, Kelly, D'hooghe, Matthias
Published in Future medicinal chemistry (01.03.2017)
Published in Future medicinal chemistry (01.03.2017)
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