Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay
DE RYCKER, Manu, HALLYBURTON, Irene, FAIRLAMB, Alan H, GRAY, David W, THOMAS, John, CAMPBELL, Lorna, WYLLIE, Susan, JOSHI, Dhananjay, CAMERON, Scott, GILBERT, Ian H, WYATT, Paul G, FREARSON, Julie A
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
Published in Antimicrobial Agents and Chemotherapy (01.07.2013)
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Journal Article
Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade
De Rycker, Manu, Thomas, John, Riley, Jennifer, Brough, Stephen J, Miles, Tim J, Gray, David W
Published in PLoS neglected tropical diseases (15.04.2016)
Published in PLoS neglected tropical diseases (15.04.2016)
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Journal Article
Identification of a potent and selective LAPTc inhibitor by RapidFire-Mass Spectrometry, with antichagasic activity
Izquierdo, Maikel, Lin, De, O'Neill, Sandra, Webster, Lauren A, Paterson, Christy, Thomas, John, Aguado, Mirtha Elisa, Colina Araújo, Enrique, Alpízar-Pedraza, Daniel, Joji, Halimatu, MacLean, Lorna, Hope, Anthony, Gray, David W, Zoltner, Martin, Field, Mark C, González-Bacerio, Jorge, De Rycker, Manu
Published in PLoS neglected tropical diseases (01.02.2024)
Published in PLoS neglected tropical diseases (01.02.2024)
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Journal Article
The R Enantiomer of the Antitubercular Drug PA-824 as a Potential Oral Treatment for Visceral Leishmaniasis
PATTERSON, Stephen, WYLLIE, Susan, STOJANOVSKI, Laste, PERRY, Meghan R, SIMEONS, Frederick R. C, NORVAL, Suzanne, OSUNA-CABELLO, Maria, DE RYCKER, Manu, READ, Kevin D, FAIRLAMB, Alan H
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
Published in Antimicrobial Agents and Chemotherapy (01.10.2013)
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Journal Article
Challenges and recent progress in drug discovery for tropical diseases
De Rycker, Manu, Baragaña, Beatriz, Duce, Suzanne L., Gilbert, Ian H.
Published in Nature (London) (01.07.2018)
Published in Nature (London) (01.07.2018)
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Journal Article
Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis
Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.
Published in Nature (London) (01.08.2018)
Published in Nature (London) (01.08.2018)
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Journal Article
Validation of Trypanosoma cruzi inactivation techniques for laboratory use
MacLean, Lorna M, Ariyanayagam, Mark, Sastry, Lalitha, Paterson, Christy, De Rycker, Manu, Fairlamb, Alan H
Published in PloS one (18.04.2024)
Published in PloS one (18.04.2024)
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Journal Article
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas' disease drug discovery
MacLean, Lorna M, Thomas, John, Lewis, Michael D, Cotillo, Ignacio, Gray, David W, De Rycker, Manu
Published in PLoS neglected tropical diseases (12.07.2018)
Published in PLoS neglected tropical diseases (12.07.2018)
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Journal Article
Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration
Lachmann, Sylvie, Jevons, Amy, De Rycker, Manu, Casamassima, Adele, Radtke, Simone, Collazos, Alejandra, Parker, Peter J
Published in PloS one (06.07.2011)
Published in PloS one (06.07.2011)
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Journal Article
Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase
Torrie, Leah S, Zuccotto, Fabio, Robinson, David A, Gray, David W, Gilbert, Ian H, De Rycker, Manu
Published in PloS one (31.05.2019)
Published in PloS one (31.05.2019)
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Journal Article
Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides
Russell, Stephanie, Rahmani, Raphaël, Jones, Amy J, Newson, Harriet L, Neilde, Kevin, Cotillo, Ignacio, Rahmani Khajouei, Marzieh, Ferrins, Lori, Qureishi, Sana, Nguyen, Nghi, Martinez-Martinez, Maria S, Weaver, Donald F, Kaiser, Marcel, Riley, Jennifer, Thomas, John, De Rycker, Manu, Read, Kevin D, Flematti, Gavin R, Ryan, Eileen, Tanghe, Scott, Rodriguez, Ana, Charman, Susan A, Kessler, Albane, Avery, Vicky M, Baell, Jonathan B, Piggott, Matthew J
Published in Journal of medicinal chemistry (10.11.2016)
Published in Journal of medicinal chemistry (10.11.2016)
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Journal Article
Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity
Nühs, Andrea, De Rycker, Manu, Manthri, Sujatha, Comer, Eamon, Scherer, Christina A, Schreiber, Stuart L, Ioset, Jean-Robert, Gray, David W
Published in PLoS neglected tropical diseases (01.09.2015)
Published in PLoS neglected tropical diseases (01.09.2015)
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Journal Article
A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes
De Rycker, Manu, O'Neill, Sandra, Joshi, Dhananjay, Campbell, Lorna, Gray, David W, Fairlamb, Alan H
Published in PLoS neglected tropical diseases (01.11.2012)
Published in PLoS neglected tropical diseases (01.11.2012)
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Journal Article
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library
Woodland, Andrew, Thompson, Stephen, Cleghorn, Laura A. T., Norcross, Neil, De Rycker, Manu, Grimaldi, Raffaella, Hallyburton, Irene, Rao, Bhavya, Norval, Suzanne, Stojanovski, Laste, Brun, Reto, Kaiser, Marcel, Frearson, Julie A., Gray, David W., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H.
Published in ChemMedChem (01.11.2015)
Published in ChemMedChem (01.11.2015)
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Journal Article
Anti-trypanosomatid drug discovery: progress and challenges
De Rycker, Manu, Wyllie, Susan, Horn, David, Read, Kevin D., Gilbert, Ian H.
Published in Nature reviews. Microbiology (01.01.2023)
Published in Nature reviews. Microbiology (01.01.2023)
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Journal Article
Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
Field, Mark C., Horn, David, Fairlamb, Alan H., Ferguson, Michael A. J., Gray, David W., Read, Kevin D., De Rycker, Manu, Torrie, Leah S., Wyatt, Paul G., Wyllie, Susan, Gilbert, Ian H.
Published in Nature reviews. Microbiology (01.04.2017)
Published in Nature reviews. Microbiology (01.04.2017)
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Journal Article