Discovery, Synthesis, And Structure-Based Optimization of a Series of N‑(tert-Butyl)-2‑(N‑arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
Jacobs, Jon, Grum-Tokars, Valerie, Zhou, Ya, Turlington, Mark, Saldanha, S. Adrian, Chase, Peter, Eggler, Aimee, Dawson, Eric S, Baez-Santos, Yahira M, Tomar, Sakshi, Mielech, Anna M, Baker, Susan C, Lindsley, Craig W, Hodder, Peter, Mesecar, Andrew, Stauffer, Shaun R
Published in Journal of medicinal chemistry (24.01.2013)
Published in Journal of medicinal chemistry (24.01.2013)
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Streptomyces coelicolor A3(2) CYP102 Protein, a Novel Fatty Acid Hydroxylase Encoded as a Heme Domain without an N-Terminal Redox Partner
Lamb, David C, Lei, Li, Zhao, Bin, Yuan, Hang, Jackson, Colin J, Warrilow, Andrew G.S, Skaug, Tove, Dyson, Paul J, Dawson, Eric S, Kelly, Steven L, Hachey, David L, Waterman, Michael R
Published in Applied and Environmental Microbiology (01.03.2010)
Published in Applied and Environmental Microbiology (01.03.2010)
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Novel Benzodiazepine Photoaffinity Probe Stereoselectively Labels a Site Deep within the Membrane-Spanning Domain of the Cholecystokinin Receptor
Hadac, Elizabeth M, Dawson, Eric S, Darrow, James W, Sugg, Elizabeth E, Lybrand, Terry P, Miller, Laurence J
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Development of a Selective Small-Molecule Inhibitor of Kir1.1, the Renal Outer Medullary Potassium Channel
Bhave, Gautam, Chauder, Brian A., Liu, Wen, Dawson, Eric S., Kadakia, Rishin, Nguyen, Thuy T., Lewis, L. Michelle, Meiler, Jens, Weaver, C. David, Satlin, Lisa M., Lindsley, Craig W., Denton, Jerod S.
Published in Molecular pharmacology (01.01.2011)
Published in Molecular pharmacology (01.01.2011)
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An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines
de Souza, Andrea, Bittker, Joshua A., Lahr, David L., Brudz, Steve, Chatwin, Simon, Oprea, Tudor I., Waller, Anna, Yang, Jeremy J., Southall, Noel, Guha, Rajarshi, Schürer, Stephan C., Vempati, Uma D., Southern, Mark R., Dawson, Eric S., Clemons, Paul A., Chung, Thomas D.Y.
Published in SLAS discovery (01.06.2014)
Published in SLAS discovery (01.06.2014)
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Optimized Translocator Protein Ligand for Optical Molecular Imaging and Screening
Li, Jun, Smith, Jarrod A, Dawson, Eric S, Fu, Allie, Nickels, Michael L, Schulte, Michael L, Manning, H. Charles
Published in Bioconjugate chemistry (19.04.2017)
Published in Bioconjugate chemistry (19.04.2017)
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A Peptide-Based Positron Emission Tomography Probe for In Vivo Detection of Caspase Activity in Apoptotic Cells
HIGHT, Matthew R, CHEUNG, Yiu-Yin, MANNING, H. Charles, NICKELS, Michael L, DAWSON, Eric S, PING ZHAO, SALEH, Samir, BUCK, Jason R, DEWEI TANG, WASHINGTON, M. Kay, COFFEY, Robert J
Published in Clinical cancer research (15.04.2014)
Published in Clinical cancer research (15.04.2014)
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Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel
Bhave, Gautam, Chauder, Brian A, Liu, Wen, Dawson, Eric S, Kadakia, Rishin, Nguyen, Thuy T, Lewis, L Michelle, Meiler, Jens, Weaver, C David, Satlin, Lisa M, Lindsley, Craig W, Denton, Jerod S
Published in Molecular pharmacology (01.01.2011)
Published in Molecular pharmacology (01.01.2011)
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Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133
Wang, Hao-Ran, Wu, Meng, Yu, Haibo, Long, Shunyou, Stevens, Amy, Engers, Darren W, Sackin, Henry, Daniels, J Scott, Dawson, Eric S, Hopkins, Corey R, Lindsley, Craig W, Li, Min, McManus, Owen B
Published in ACS chemical biology (19.08.2011)
Published in ACS chemical biology (19.08.2011)
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Measurement of Intermolecular Distances for the Natural Agonist Peptide Docked at the Cholecystokinin Receptor Expressed in Situ Using Fluorescence Resonance Energy Transfer
Harikumar, Kaleeckal G, Pinon, Delia I, Wessels, William S, Dawson, Eric S, Lybrand, Terry P, Prendergast, Franklyn G, Miller, Laurence J
Published in Molecular pharmacology (01.01.2004)
Published in Molecular pharmacology (01.01.2004)
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A Model for the Solution Structure of the Rod Arrestin Tetramer
Hanson, Susan M., Dawson, Eric S., Francis, Derek J., Van Eps, Ned, Klug, Candice S., Hubbell, Wayne L., Meiler, Jens, Gurevich, Vsevolod V.
Published in Structure (London) (01.06.2008)
Published in Structure (London) (01.06.2008)
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Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies
Kaufmann, Kristian W., Dawson, Eric S., Henry, L. Keith, Field, Julie R., Blakely, Randy D., Meiler, Jens
Published in Proteins, structure, function, and bioinformatics (15.02.2009)
Published in Proteins, structure, function, and bioinformatics (15.02.2009)
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A Conserved Asparagine Residue in Transmembrane Segment 1 (TM1) of Serotonin Transporter Dictates Chloride-coupled Neurotransmitter Transport
Henry, L. Keith, Iwamoto, Hideki, Field, Julie R., Kaufmann, Kristian, Dawson, Eric S., Jacobs, Miriam T., Adams, Chelsea, Felts, Bruce, Zdravkovic, Igor, Armstrong, Vanessa, Combs, Steven, Solis, Ernesto, Rudnick, Gary, Noskov, Sergei Y., DeFelice, Louis J., Meiler, Jens, Blakely, Randy D.
Published in The Journal of biological chemistry (02.09.2011)
Published in The Journal of biological chemistry (02.09.2011)
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Discovery and Characterization of Novel Subtype-Selective Allosteric Agonists for the Investigation of M 1 Receptor Function in the Central Nervous System
Lebois, Evan P, Bridges, Thomas M, Lewis, L. Michelle, Dawson, Eric S, Kane, Alexander S., Xiang, Zixiu, Jadhav, Satyawan B, Yin, Huiyong, Kennedy, J. Phillip, Meiler, Jens, Niswender, Colleen M., Jones, Carrie K, Conn, P Jeffrey, Weaver, C David, Lindsley, Craig W
Published in ACS chemical neuroscience (17.02.2010)
Published in ACS chemical neuroscience (17.02.2010)
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The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibitor with Robust Effects in STN Neurons and in a Rodent Model of Parkinson’s Disease
Xiang, Zixiu, Thompson, Analisa D, Brogan, John T, Schulte, Michael L, Melancon, Bruce J, Mi, Debbie, Lewis, L. Michelle, Zou, Bende, Yang, Liya, Morrison, Ryan, Santomango, Tammy, Byers, Frank, Brewer, Katrina, Aldrich, Jonathan S, Yu, Haibo, Dawson, Eric S, Li, Min, McManus, Owen, Jones, Carrie K, Daniels, J. Scott, Hopkins, Corey R, Xie, Ximin Simon, Conn, P. Jeffrey, Weaver, C. David, Lindsley, Craig W
Published in ACS chemical neuroscience (21.12.2011)
Published in ACS chemical neuroscience (21.12.2011)
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Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway
Theriault, Jimmy R., Felts, Andrew S., Bates, Brittney S., Perez, Jose R., Palmer, Michelle, Gilbert, Shawn R., Dawson, Eric S., Engers, Julie L., Lindsley, Craig W., Emmitte, Kyle A.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound
Mueller, Ralf, Dawson, Eric S, Meiler, Jens, Rodriguez, Alice L, Chauder, Brian A, Bates, Brittney S, Felts, Andrew S, Lamb, Jeffrey P, Menon, Usha N, Jadhav, Sataywan B, Kane, Alexander S, Jones, Carrie K, Gregory, Karen J, Niswender, Colleen M, Conn, P. Jeffrey, Olsen, Christopher M, Winder, Danny G, Emmitte, Kyle A, Lindsley, Craig W
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
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Discovery of 2-(2-Benzoxazoyl amino)-4-Aryl-5-Cyanopyrimidine as Negative Allosteric Modulators (NAMs) of Metabotropic Glutamate Receptor 5 (mGlu5): From an Artificial Neural Network Virtual Screen to an In Vivo Tool Compound
Mueller, Ralf, Dawson, Eric S., Meiler, Jens, Rodriguez, Alice L., Chauder, Brian A., Bates, Brittney S., Felts, Andrew S., Lamb, Jeffrey P., Menon, Usha N., Jadhav, Sataywan B., Kane, Alexander S., Jones, Carrie K., Gregory, Karen J., Niswender, Colleen M., Conn, P. Jeffrey, Olsen, Christopher M., Winder, Danny G., Emmitte, Kyle A., Lindsley, Craig W.
Published in ChemMedChem (05.03.2012)
Published in ChemMedChem (05.03.2012)
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