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Brown, Matthew, Leon, Alicia, Kedzierska, Katarzyna, Moore, Charlotte, Belnoue-Davis, Hayley L, Flach, Susanne, Lydon, John P, DeMayo, Francesco J, Lewis, Annabelle, Bosse, Tjalling, Tomlinson, Ian, Church, David N
Published in EMBO molecular medicine (11.10.2023)
Published in EMBO molecular medicine (11.10.2023)
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Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.
Published in Nature communications (07.12.2022)
Published in Nature communications (07.12.2022)
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Author Correction: Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features
Flanagan, Dustin J., Amirkhah, Raheleh, Vincent, David F., Gunduz, Nuray, Gentaz, Pauline, Cammareri, Patrizia, McCooey, Aoife J., McCorry, Amy M. B., Fisher, Natalie C., Davis, Hayley L., Ridgway, Rachel A., Lohuis, Jeroen, Leach, Joshua D. G., Jackstadt, Rene, Gilroy, Kathryn, Mariella, Elisa, Nixon, Colin, Clark, William, Hedley, Ann, Markert, Elke K., Strathdee, Douglas, Bartholin, Laurent, Redmond, Keara L., Kerr, Emma M., Longley, Daniel B., Ginty, Fiona, Cho, Sanghee, Coleman, Helen G., Loughrey, Maurice B., Bardelli, Alberto, Maughan, Timothy S., Campbell, Andrew D., Lawler, Mark, Leedham, Simon J., Barry, Simon T., Inman, Gareth J., van Rheenen, Jacco, Dunne, Philip D., Sansom, Owen J.
Published in Nature communications (31.01.2023)
Published in Nature communications (31.01.2023)
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Molecular mechanism of BMP signal control by Twisted gastrulation
Malinauskas, Tomas, Moore, Gareth, Rudolf, Amalie F., Eggington, Holly, Belnoue-Davis, Hayley L., El Omari, Kamel, Griffiths, Samuel C., Woolley, Rachel E., Duman, Ramona, Wagner, Armin, Leedham, Simon J., Baldock, Clair, Ashe, Hilary L., Siebold, Christian
Published in Nature communications (11.06.2024)
Published in Nature communications (11.06.2024)
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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
Vasquez, Ester Gil, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Published in Cell stem cell (04.08.2022)
Published in Cell stem cell (04.08.2022)
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Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.
Published in Nature genetics (01.03.2024)
Published in Nature genetics (01.03.2024)
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Author Correction: Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer
Malla, Sudhir B., Byrne, Ryan M., Lafarge, Maxime W., Corry, Shania M., Fisher, Natalie C., Tsantoulis, Petros K., Mills, Megan L., Ridgway, Rachel A., Lannagan, Tamsin R. M., Najumudeen, Arafath K., Gilroy, Kathryn L., Amirkhah, Raheleh, Maguire, Sarah L., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Grassi, Elena, Viviani, Marco, Rogan, Emily, Redmond, Keara L., Sakhnevych, Svetlana, McCooey, Aoife J., Bull, Courtney, Hoey, Emily, Sinevici, Nicoleta, Hall, Holly, Ahmaderaghi, Baharak, Domingo, Enric, Blake, Andrew, Richman, Susan D., Isella, Claudio, Miller, Crispin, Bertotti, Andrea, Trusolino, Livio, Loughrey, Maurice B., Kerr, Emma M., Tejpar, Sabine, Maughan, Timothy S., Lawler, Mark, Campbell, Andrew D., Leedham, Simon J., Koelzer, Viktor H., Sansom, Owen J., Dunne, Philip D.
Published in Nature genetics (01.06.2024)
Published in Nature genetics (01.06.2024)
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Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia
Gil Vazquez, Ester, Nasreddin, Nadia, Valbuena, Gabriel N., Mulholland, Eoghan J., Belnoue-Davis, Hayley L., Eggington, Holly R., Schenck, Ryan O., Wouters, Valérie M., Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R.M., Flanagan, Dustin J., Najumudeen, Arafath K., Omwenga, Sulochana, McCorry, Amy M.B., Easton, Alistair, Koelzer, Viktor H., East, James E., Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D., Loughrey, Maurice B., Dunne, Philip D., Tsantoulis, Petros, Huels, David J., Tejpar, Sabine, Sansom, Owen J., Leedham, Simon J.
Published in Cell stem cell (03.11.2022)
Published in Cell stem cell (03.11.2022)
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β-Catenin Drives Butyrophilin-like Molecule Loss and γδ T-cell Exclusion in Colon Cancer
Suzuki, Toshiyasu, Kilbey, Anna, Casa-Rodríguez, Nuria, Lawlor, Amy, Georgakopoulou, Anastasia, Hayman, Hannah, Yin Swe, Kyi Lai, Nordin, Anna, Cantù, Claudio, Vantourout, Pierre, Ridgway, Rachel A, Byrne, Ryan M, Chen, Lei, Verzi, Michael P, Gay, David M, Gil Vázquez, Ester, Belnoue-Davis, Hayley L, Gilroy, Kathryn, Køstner, Anne Helene, Kersten, Christian, Thuwajit, Chanitra, Andersen, Ditte K, Wiesheu, Robert, Jandke, Anett, Blyth, Karen, Roseweir, Antonia K, Leedham, Simon J, Dunne, Philip D, Edwards, Joanne, Hayday, Adrian, Sansom, Owen J, Coffelt, Seth B
Published in Cancer immunology research (03.08.2023)
Published in Cancer immunology research (03.08.2023)
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399 Aberrant Epithelial GREM1 Expression Promotes Stem-Cell Plasticity and Ectopic Crypt Formation in the Pathogenesis of Familial and Sporadic Human Polyps
Davis, Hayley L, Irshad, Shazia, Rafferty, Hannah, Boitsova, Tatjana, Jeffery, Rosemary, Richard, Poulsom, Bansal, Mukesh, Wang, Lai M, Rodriguez-Justo, Manuel, Novelli, Marco, Silver, Andrew, East, James E, Tomlinson, Ian, Leedham, Simon
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
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110 Aberrant Epithelial Expression of the BMP Antagonist GREMLIN1 in Human Colorectal Lesions and a Mouse Model of Hereditary Mixed Polyposis Syndrome (HMPS) Acts via Promotion of a Stem-Cell Phenotype
Davis, Hayley L, Cuadrado, Pedro Rodenas, Bardella, Chiara, Lewis, Annabelle, Emma, Jaeger, Mallappa, Sreelakshmi, Clark, Susan K, East, James, Chetty, Runjan, Tomlinson, Ian, Leedham, Simon
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2013)
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Platelets Sequester Extracellular DNA, Capturing Tumour-Derived and Free Fetal DNA
Murphy, Lauren, Inchauspe, Jeanne, Sousos, Nikolaos, Jooss, Natalie, Belnoue-Davis, Hayley L, Holland, Pamela, Li, Rong, Valenzano, Giampiero, Roseman, Fenella, Biswas, Sujata, Clark, Sally-Ann, O'Sullivan, Jennifer, Rimmer, Michael, Khan, Abdullah O, Simoglou Karali, Christina, ONeill, Eric, Nasreddin, Nadia, Hitchcock, Ian, Koupenova, Milka, Vatish, Manu, Rees, Paul, Leedham, Simon, Mead, Adam J, Schuster-Boeckler, Benjamin, Gregory, Christopher, Psaila, Bethan
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Low coverage whole genome sequencing of low-grade dysplasia strongly predicts colorectal cancer risk in ulcerative colitis
Al Bakir, Ibrahim, Curtius, Kit, Cresswell, George D, Grant, Heather E, Nasreddin, Nadia, Smith, Kane, Nowinski, Salpie, Guo, Qingli, Belnoue-Davis, Hayley L, Fisher, Jennifer, Clarke, Theo, Kimberley, Christopher, Mossner, Maximilian, Dunne, Philip D, Loughrey, Maurice B, Speight, Ally, East, James E, Wright, Nicholas A, Rodriguez-Justo, Manuel, Jansen, Marnix, Moorghen, Morgan, Baker, Ann-Marie, Leedham, Simon J, Hart, Ailsa L, Graham, Trevor A
Published in medRxiv : the preprint server for health sciences (08.07.2024)
Published in medRxiv : the preprint server for health sciences (08.07.2024)
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β-catenin obstructs γδ T cell immunosurveillance in colon cancer through loss of BTNL expression
Suzuki, Toshiyasu, Kilbey, Anna, Ridgway, Rachel A, Hayman, Hannah, Byrne, Ryan, Nuria Casa Rodriguez, Georgakopoulou, Anastasia, Chen, Lei, Verzi, Michael, Gay, David M, Vzquez, Ester G, Belnoue-Davis, Hayley L, Gilroy, Kathryn, Kostner, Anne Helene, Kersten, Christian, Thuwajit, Chanitra, Andersen, Ditte, Wiesheu, Robert, Jandke, Anett, Roberts, Natalie, Blyth, Karen, Roseweir, Antonia, Leedham, Simon J, Dunne, Philip D, Edwards, Joanne, Hayday, Adrian, Sansom, Owen J, Coffelt, Seth B
Published in bioRxiv (12.06.2022)
Published in bioRxiv (12.06.2022)
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Molecular phenotyping of colorectal neoplasia shows dynamic and adaptive cancer stem cell population admixture
Ester Gil Vazquez, Nasreddin, Nadia, Valbuena, Gabriel N, Mulholland, Eoghan J, Belnoue-Davis, Hayley L, Eggington, Holly, Schenck, Ryan O, Wouters, Valerie M, Wirapati, Pratyaksha, Gilroy, Kathryn, Lannagan, Tamsin R M, Flanagan, Dustin J, Najumudeen, Arafath K, Omwenga, Sulochana, Mccorry, Amy M B, Easton, Alistair, Koelzer, Viktor H, East, James E, Morton, Dion, Trusolino, Livio, Maughan, Timothy, Campbell, Andrew D, Loughrey, Maurice B, Dunne, Philip D, Tsantoulis, Petros, Huels, David J, Tejpar, Sabine, Sansom, Owen, Leedham, Simon J
Published in bioRxiv (20.08.2022)
Published in bioRxiv (20.08.2022)
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