AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity
Fok, Jacqueline H L, Ramos-Montoya, Antonio, Vazquez-Chantada, Mercedes, Wijnhoven, Paul W G, Follia, Valeria, James, Neil, Farrington, Paul M, Karmokar, Ankur, Willis, Sophie E, Cairns, Jonathan, Nikkilä, Jenni, Beattie, David, Lamont, Gillian M, Finlay, M Raymond V, Wilson, Joanne, Smith, Aaron, O'Connor, Lenka Oplustil, Ling, Stephanie, Fawell, Stephen E, O'Connor, Mark J, Hollingsworth, Simon J, Dean, Emma, Goldberg, Frederick W, Davies, Barry R, Cadogan, Elaine B
Published in Nature communications (07.11.2019)
Published in Nature communications (07.11.2019)
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Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors
Sommer, Eeva M, Dry, Hannah, Cross, Darren, Guichard, Sylvie, Davies, Barry R, Alessi, Dario R
Published in Biochemical journal (15.06.2013)
Published in Biochemical journal (15.06.2013)
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A Phase I Open-Label Study to Identify a Dosing Regimen of the Pan-AKT Inhibitor AZD5363 for Evaluation in Solid Tumors and in PIK3CA -Mutated Breast and Gynecologic Cancers
Banerji, Udai, Dean, Emma J, Pérez-Fidalgo, J Alejandro, Batist, Gerald, Bedard, Philippe L, You, Benoit, Westin, Shannon N, Kabos, Peter, Garrett, Michelle D, Tall, Mathew, Ambrose, Helen, Barrett, J Carl, Carr, T Hedley, Cheung, S Y Amy, Corcoran, Claire, Cullberg, Marie, Davies, Barry R, de Bruin, Elza C, Elvin, Paul, Foxley, Andrew, Lawrence, Peter, Lindemann, Justin P O, Maudsley, Rhiannon, Pass, Martin, Rowlands, Vicky, Rugman, Paul, Schiavon, Gaia, Yates, James, Schellens, Jan H M
Published in Clinical cancer research (01.05.2018)
Published in Clinical cancer research (01.05.2018)
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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia
Balachander, Srividya B., Criscione, Steven W., Byth, Kate F., Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W., Kurtz, Stephen E., McWeeney, Shannon K., Varnes, Jeffrey, Diebold, R. Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J., McCoull, William, Saeh, Jamal C., Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Gregory, Gareth P., Newbold, Andrea, Johnstone, Ricky W., Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J. Paul, Davies, Barry R., Fawell, Stephen E., Gibbons, Francis D.
Published in Clinical cancer research (15.12.2020)
Published in Clinical cancer research (15.12.2020)
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The Discovery of 7‑Methyl-2-[(7-methyl[1,2,4]triazolo[1,5‑a]pyridin-6-yl)amino]-9-(tetrahydro‑2H‑pyran-4-yl)-7,9-dihydro‑8H‑purin-8-one (AZD7648), a Potent and Selective DNA-Dependent Protein Kinase (DNA-PK) Inhibitor
Goldberg, Frederick W, Finlay, M. Raymond V, Ting, Attilla K. T, Beattie, David, Lamont, Gillian M, Fallan, Charlene, Wrigley, Gail L, Schimpl, Marianne, Howard, Martin R, Williamson, Beth, Vazquez-Chantada, Mercedes, Barratt, Derek G, Davies, Barry R, Cadogan, Elaine B, Ramos-Montoya, Antonio, Dean, Emma
Published in Journal of medicinal chemistry (09.04.2020)
Published in Journal of medicinal chemistry (09.04.2020)
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AZD2014, an Inhibitor of mTORC1 and mTORC2, Is Highly Effective in ER+ Breast Cancer When Administered Using Intermittent or Continuous Schedules
Guichard, Sylvie M, Curwen, Jon, Bihani, Teeru, D'Cruz, Celina M, Yates, James W T, Grondine, Michael, Howard, Zoe, Davies, Barry R, Bigley, Graham, Klinowska, Teresa, Pike, Kurt G, Pass, Martin, Chresta, Christine M, Polanska, Urszula M, McEwen, Robert, Delpuech, Oona, Green, Stephen, Cosulich, Sabina C
Published in Molecular cancer therapeutics (01.11.2015)
Published in Molecular cancer therapeutics (01.11.2015)
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AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models
Davies, Barry R, Logie, Armelle, McKay, Jennifer S, Martin, Paul, Steele, Samantha, Jenkins, Richard, Cockerill, Mark, Cartlidge, Sue, Smith, Paul D
Published in Molecular cancer therapeutics (01.08.2007)
Published in Molecular cancer therapeutics (01.08.2007)
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Blocked Autophagy Using Lysosomotropic Agents Sensitizes Resistant Prostate Tumor Cells to the Novel Akt Inhibitor AZD5363
LAMOUREUX, Francois, THOMAS, Christian, CRAFTER, Claire, KUMANO, Masafumi, FAN ZHANG, DAVIES, Barry R, GLEAVE, Martin E, ZOUBEIDI, Amina
Published in Clinical cancer research (15.02.2013)
Published in Clinical cancer research (15.02.2013)
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Genetic Alterations in the PI3K/AKT Pathway and Baseline AKT Activity Define AKT Inhibitor Sensitivity in Breast Cancer Patient-derived Xenografts
Gris-Oliver, Albert, Palafox, Marta, Monserrat, Laia, Brasó-Maristany, Fara, Òdena, Andreu, Sánchez-Guixé, Mònica, Ibrahim, Yasir H, Villacampa, Guillermo, Grueso, Judit, Parés, Mireia, Guzmán, Marta, Rodríguez, Olga, Bruna, Alejandra, Hirst, Caroline S, Barnicle, Alan, de Bruin, Elza C, Reddy, Avinash, Schiavon, Gaia, Arribas, Joaquín, Mills, Gordon B, Caldas, Carlos, Dienstmann, Rodrigo, Prat, Aleix, Nuciforo, Paolo, Razavi, Pedram, Scaltriti, Maurizio, Turner, Nicholas C, Saura, Cristina, Davies, Barry R, Oliveira, Mafalda, Serra, Violeta
Published in Clinical cancer research (15.07.2020)
Published in Clinical cancer research (15.07.2020)
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Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy
Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R., Owen, David J., Ashford, Marianne B.
Published in Communications biology (25.01.2021)
Published in Communications biology (25.01.2021)
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MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
Zelceski, Anabel, Francica, Paola, Lingg, Lea, Mutlu, Merve, Stok, Colin, Liptay, Martin, Alexander, John, Baxter, Joseph S., Brough, Rachel, Gulati, Aditi, Haider, Syed, Raghunandan, Maya, Song, Feifei, Sridhar, Sandhya, Forment, Josep V., O’Connor, Mark J., Davies, Barry R., van Vugt, Marcel A.T.M., Krastev, Dragomir B., Pettitt, Stephen J., Tutt, Andrew N.J., Rottenberg, Sven, Lord, Christopher J.
Published in Cell reports (Cambridge) (30.05.2023)
Published in Cell reports (Cambridge) (30.05.2023)
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Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)
HOLT, Sarah V, LOGIE, Armelle, WILKINSON, Robert W, GUICHARD, Sylvie M, SMITH, Paul D, DAVIES, Barry R, ALFEREZ, Denis, RUNSWICK, Sarah, FENTON, Sarah, CHRESTA, Christine M, YI GU, JINGCHUAN ZHANG, WU, Yi-Long
Published in Cancer research (Chicago, Ill.) (01.04.2012)
Published in Cancer research (Chicago, Ill.) (01.04.2012)
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Optimizing the design of population-based patient-derived tumor xenograft studies to better predict clinical response
Floc'h, Nicolas, Guerriero, Maria Luisa, Ramos-Montoya, Antonio, Davies, Barry R, Cairns, Jonathan, Karp, Natasha A
Published in Disease models & mechanisms (01.11.2018)
Published in Disease models & mechanisms (01.11.2018)
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Preclinical anticancer activity of the potent, oral Src inhibitor AZD0530
Green, Tim P., Fennell, Mike, Whittaker, Robin, Curwen, Jon, Jacobs, Vivien, Allen, Jack, Logie, Armelle, Hargreaves, Judith, Hickinson, D. Mark, Wilkinson, Robert W., Elvin, Paul, Boyer, Brigitte, Carragher, Neil, Plé, Patrick A., Bermingham, Alun, Holdgate, Geoffrey A., Ward, Walter H.J., Hennequin, Laurent F., Davies, Barry R., Costello, Gerard F.
Published in Molecular oncology (01.06.2009)
Published in Molecular oncology (01.06.2009)
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Diverse Heterocyclic Scaffolds as Allosteric Inhibitors of AKT
Kettle, Jason G, Brown, Simon, Crafter, Claire, Davies, Barry R, Dudley, Phillippa, Fairley, Gary, Faulder, Paul, Fillery, Shaun, Greenwood, Hannah, Hawkins, Janet, James, Michael, Johnson, Keith, Lane, Clare D, Pass, Martin, Pink, Jennifer H, Plant, Helen, Cosulich, Sabina C
Published in Journal of medicinal chemistry (09.02.2012)
Published in Journal of medicinal chemistry (09.02.2012)
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Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer
Astanehe, Arezoo, Arenillas, David, Wasserman, Wyeth W, Leung, Peter C.K, Dunn, Sandra E, Davies, Barry R, Mills, Gordon B, Auersperg, Nelly
Published in Journal of cell science (01.03.2008)
Published in Journal of cell science (01.03.2008)
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Evaluation of the Therapeutic Potential of the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Gefitinib in Preclinical Models of Bladder Cancer
DOMINGUEZ-ESCRIG, Jose L, KELLY, John D, NEAL, David E, KING, Sonya M, DAVIES, Barry R
Published in Clinical cancer research (15.07.2004)
Published in Clinical cancer research (15.07.2004)
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Combination AZD5363 with Enzalutamide Significantly Delays Enzalutamide-resistant Prostate Cancer in Preclinical Models
Toren, Paul, Kim, Soojin, Cordonnier, Thomas, Crafter, Claire, Davies, Barry R, Fazli, Ladan, Gleave, Martin E, Zoubeidi, Amina
Published in European urology (01.06.2015)
Published in European urology (01.06.2015)
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