Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism
Bagnéris, Claire, DeCaen, Paul G., Naylor, Claire E., Pryde, David C., Nobeli, Irene, Clapham, David E., Wallace, B. A.
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (10.06.2014)
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The discovery of potent small molecule activators of human STING
Pryde, David C., Middya, Sandip, Banerjee, Monali, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Yadav, Dharmendra B., Surya, Arjun
Published in European journal of medicinal chemistry (01.01.2021)
Published in European journal of medicinal chemistry (01.01.2021)
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G10 is a direct activator of human STING
Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Pryde, David C, Yadav, Dharmendra B, Surya, Arjun
Published in PloS one (10.09.2020)
Published in PloS one (10.09.2020)
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The discovery of potent small molecule cyclic urea activators of STING
Basu, Sourav, Middya, Sandip, Banerjee, Monali, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Shrivastava, Ritesh, Surya, Arjun
Published in European journal of medicinal chemistry (05.02.2022)
Published in European journal of medicinal chemistry (05.02.2022)
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Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery
Pryde, David C, Dalvie, Deepak, Hu, Qiyue, Jones, Peter, Obach, R. Scott, Tran, Thien-Duc
Published in Journal of medicinal chemistry (23.12.2010)
Published in Journal of medicinal chemistry (23.12.2010)
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Selection of a novel anti-nicotine vaccine: influence of antigen design on antibody function in mice
Pryde, David C, Jones, Lyn H, Gervais, David P, Stead, David R, Blakemore, David C, Selby, Matthew D, Brown, Alan D, Coe, Jotham W, Badland, Matthew, Beal, David M, Glen, Rebecca, Wharton, Yvonne, Miller, Gavin J, White, Phil, Zhang, Ningli, Benoit, Michelle, Robertson, Karen, Merson, James R, Davis, Heather L, McCluskie, Michael J
Published in PloS one (01.10.2013)
Published in PloS one (01.10.2013)
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Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site
LAXTON, Carl, BRADY, Kevin, MOSCHOS, Sterghios, TURNPENNY, Paul, RAWAL, Jaiessh, PRYDE, David C, SIDDERS, Ben, CORBAU, Romu, PICKFORD, Chris, MURRAY, E. J
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
Published in Antimicrobial Agents and Chemotherapy (01.07.2011)
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Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn( tBu) 2 and applications in in situ cross coupling reactions
Blair, Victoria L., Blakemore, David C., Hay, Duncan, Hevia, Eva, Pryde, David C.
Published in Tetrahedron letters (01.09.2011)
Published in Tetrahedron letters (01.09.2011)
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An Imidazopiperidine Series of CCR5 Antagonists for the Treatment of HIV: The Discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide (PF-232798)
Stupple, Paul A, Batchelor, David V, Corless, Martin, Dorr, Patrick K, Ellis, David, Fenwick, David R, Galan, Sébastien R. G, Jones, Rhys M, Mason, Helen J, Middleton, Donald S, Perros, Manos, Perruccio, Francesca, Platts, Michelle Y, Pryde, David C, Rodrigues, Deborah, Smith, Nicholas N, Stephenson, Peter T, Webster, Robert, Westby, Mike, Wood, Anthony
Published in Journal of medicinal chemistry (13.01.2011)
Published in Journal of medicinal chemistry (13.01.2011)
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Practical synthetic routes to carbon-substituted nucleosides
Pryde, David C., Middleton, Donald S., Stephenson, Peter T., Wainwright, Philip, Maddaford, Adrian, Zhang, Xiurong, Leese, David, Glen, Rebecca, Hart, James, Forrest, Neil, Guyot, Thierry
Published in Tetrahedron letters (30.11.2011)
Published in Tetrahedron letters (30.11.2011)
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A pharmacological master key mechanism that unlocks the selectivity filter gate in K + channels
Schewe, Marcus, Sun, Han, Mert, Ümit, Mackenzie, Alexandra, Pike, Ashley C W, Schulz, Friederike, Constantin, Cristina, Vowinkel, Kirsty S, Conrad, Linus J, Kiper, Aytug K, Gonzalez, Wendy, Musinszki, Marianne, Tegtmeier, Marie, Pryde, David C, Belabed, Hassane, Nazare, Marc, de Groot, Bert L, Decher, Niels, Fakler, Bernd, Carpenter, Elisabeth P, Tucker, Stephen J, Baukrowitz, Thomas
Published in Science (American Association for the Advancement of Science) (22.02.2019)
Published in Science (American Association for the Advancement of Science) (22.02.2019)
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Valproic acid interactions with the NavMs voltage-gated sodium channel
Zanatta, Geancarlo, Sula, Altin, Miles, Andrew J., Ng, Leo C. T., Torella, Rubben, Pryde, David C., DeCaen, Paul G., Wallace, B. A.
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (26.12.2019)
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Ion Channels as Therapeutic Targets: A Drug Discovery Perspective
Bagal, Sharan K, Brown, Alan D, Cox, Peter J, Omoto, Kiyoyuki, Owen, Robert M, Pryde, David C, Sidders, Benjamin, Skerratt, Sarah E, Stevens, Edward B, Storer, R. Ian, Swain, Nigel A
Published in Journal of medicinal chemistry (14.02.2013)
Published in Journal of medicinal chemistry (14.02.2013)
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Design and Identification of a Novel, Functionally Subtype Selective GABAA Positive Allosteric Modulator (PF-06372865)
Owen, Robert M, Blakemore, David, Cao, Lishuang, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R, Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A, Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C, Reynolds, David S, Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S, Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation-π Interaction
Rooney, Timothy P. C., Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Cortopassi, Wilian A., Hay, Duncan A., Martin, Sarah, Tumber, Anthony, Rogers, Catherine M., Philpott, Martin, Wang, Minghua, Thompson, Amber L., Heightman, Tom D., Pryde, David C., Cook, Andrew, Paton, Robert S., Müller, Susanne, Knapp, Stefan, Brennan, Paul E., Conway, Stuart J.
Published in Angewandte Chemie International Edition (10.06.2014)
Published in Angewandte Chemie International Edition (10.06.2014)
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TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype
Tseng, Wei Chou, Pryde, David C., Yoger, Katrina E., Padilla, Karen M., Antonio, Brett M., Han, Seungil, Shanmugasundaram, Veerabahu, Gerlach, Aaron C.
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2018)
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Design and Identification of a Novel, Functionally Subtype Selective GABA(A) Positive Allosteric Modulator (PF-06372865)
Owen, Robert M., Blakemore, David, Cao, Lishuan, Flanagan, Neil, Fish, Rebecca, Gibson, Karl R., Gurrell, Rachel, Huh, Chan Woo, Kammonen, Juha, Mortimer-Cassen, Elisabeth, Nickolls, Sarah A., Omoto, Kiyoyuki, Owen, Dafydd, Pike, Andy, Pryde, David C., Reynolds, David S., Roeloffs, Rosemarie, Rose, Colin, Stead, Clara, Takeuchi, Mifune, Warmus, Joseph S., Watson, Christine
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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An Intracellular Allosteric Modulator Binding Pocket in SK2 Ion Channels Is Shared by Multiple Chemotypes
Cho, Lily T.-Y., Alexandrou, Aristos J., Torella, Rubben, Knafels, John, Hobbs, Jake, Taylor, Toni, Loucif, Alex, Konopacka, Agnieszka, Bell, Sigourney, Stevens, Edward B., Pandit, Jay, Horst, Reto, Withka, Jane M., Pryde, David C., Liu, Shenping, Young, Gareth T.
Published in Structure (London) (03.04.2018)
Published in Structure (London) (03.04.2018)
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