Nanoparticle‐Conjugate TLR7/8 Agonist Localized Immunotherapy Provokes Safe Antitumoral Responses
Nuhn, Lutz, De Koker, Stefaan, Van Lint, Sandra, Zhong, Zifu, Catani, João Portela, Combes, Francis, Deswarte, Kim, Li, Yupeng, Lambrecht, Bart N., Lienenklaus, Stefan, Sanders, Niek N., David, Sunil A., Tavernier, Jan, De Geest, Bruno G.
Published in Advanced materials (Weinheim) (01.11.2018)
Published in Advanced materials (Weinheim) (01.11.2018)
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Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands
Zhang, Zhikuan, Ohto, Umeharu, Shibata, Takuma, Taoka, Masato, Yamauchi, Yoshio, Sato, Ryota, Shukla, Nikunj M., David, Sunil A., Isobe, Toshiaki, Miyake, Kensuke, Shimizu, Toshiyuki
Published in Cell reports (Cambridge) (18.12.2018)
Published in Cell reports (Cambridge) (18.12.2018)
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Sterilizing Immunity against SARS‐CoV‐2 Infection in Mice by a Single‐Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist‐Adjuvanted Recombinant Spike Protein Vaccine
Jangra, Sonia, De Vrieze, Jana, Choi, Angela, Rathnasinghe, Raveen, Laghlali, Gabriel, Uvyn, Annemiek, Van Herck, Simon, Nuhn, Lutz, Deswarte, Kim, Zhong, Zifu, Sanders, Niek N., Lienenklaus, Stefan, David, Sunil A., Strohmeier, Shirin, Amanat, Fatima, Krammer, Florian, Hammad, Hamida, Lambrecht, Bart N., Coughlan, Lynda, García‐Sastre, Adolfo, De Geest, Bruno G., Schotsaert, Michael
Published in Angewandte Chemie International Edition (19.04.2021)
Published in Angewandte Chemie International Edition (19.04.2021)
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pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation
Nuhn, Lutz, Vanparijs, Nane, De Beuckelaer, Ans, Lybaert, Lien, Verstraete, Glenn, Deswarte, Kim, Lienenklaus, Stefan, Shukla, Nikunj M., Salyer, Alex C. D., Lambrecht, Bart N., Grooten, Johan, David, Sunil A., De Koker, Stefaan, De Geest, Bruno G.
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (19.07.2016)
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Potent and Prolonged Innate Immune Activation by Enzyme-Responsive Imidazoquinoline TLR7/8 Agonist Prodrug Vesicles
Wang, Bi, Van Herck, Simon, Chen, Yong, Bai, Xiangyang, Zhong, Zifu, Deswarte, Kim, Lambrecht, Bart N, Sanders, Niek N, Lienenklaus, Stefan, Scheeren, Hans W, David, Sunil A, Kiessling, Fabian, Lammers, Twan, De Geest, Bruno G, Shi, Yang
Published in Journal of the American Chemical Society (15.07.2020)
Published in Journal of the American Chemical Society (15.07.2020)
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The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes
Ganapathi, Lakshmi, Van Haren, Simon, Dowling, David J, Bergelson, Ilana, Shukla, Nikunj M, Malladi, Subbalakshmi S, Balakrishna, Rajalakshmi, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A, Levy, Ofer
Published in PloS one (14.08.2015)
Published in PloS one (14.08.2015)
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Squaric Ester-Based, pH-Degradable Nanogels: Modular Nanocarriers for Safe, Systemic Administration of Toll-like Receptor 7/8 Agonistic Immune Modulators
Huppertsberg, Anne, Kaps, Leonard, Zhong, Zifu, Schmitt, Sascha, Stickdorn, Judith, Deswarte, Kim, Combes, Francis, Czysch, Christian, De Vrieze, Jana, Kasmi, Sabah, Choteschovsky, Niklas, Klefenz, Adrian, Medina-Montano, Carolina, Winterwerber, Pia, Chen, Chaojian, Bros, Matthias, Lienenklaus, Stefan, Sanders, Niek N, Koynov, Kaloian, Schuppan, Detlef, Lambrecht, Bart N, David, Sunil A, De Geest, Bruno G, Nuhn, Lutz
Published in Journal of the American Chemical Society (07.07.2021)
Published in Journal of the American Chemical Society (07.07.2021)
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Systemically Administered TLR7/8 Agonist and Antigen-Conjugated Nanogels Govern Immune Responses against Tumors
Stickdorn, Judith, Stein, Lara, Arnold-Schild, Danielle, Hahlbrock, Jennifer, Medina-Montano, Carolina, Bartneck, Joschka, Ziß, Tanja, Montermann, Evelyn, Kappel, Cinja, Hobernik, Dominika, Haist, Maximilian, Yurugi, Hajime, Raabe, Marco, Best, Andreas, Rajalingam, Krishnaraj, Radsak, Markus P, David, Sunil A, Koynov, Kaloian, Bros, Matthias, Grabbe, Stephan, Schild, Hansjörg, Nuhn, Lutz
Published in ACS nano (22.03.2022)
Published in ACS nano (22.03.2022)
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Potent anti-viral vaccine adjuvant based on pH-degradable nanogels with covalently linked small molecule imidazoquinoline TLR7/8 agonist
Nuhn, Lutz, Van Hoecke, Lien, Deswarte, Kim, Schepens, Bert, Li, Yupeng, Lambrecht, Bart N., De Koker, Stefaan, David, Sunil A., Saelens, Xavier, De Geest, Bruno G.
Published in Biomaterials (01.09.2018)
Published in Biomaterials (01.09.2018)
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Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer
Shukla, Nikunj M, Salunke, Deepak B, Balakrishna, Rajalakshmi, Mutz, Cole A, Malladi, Subbalakshmi S, David, Sunil A
Published in PloS one (28.08.2012)
Published in PloS one (28.08.2012)
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Potent Lymphatic Translocation and Spatial Control Over Innate Immune Activation by Polymer–Lipid Amphiphile Conjugates of Small‐Molecule TLR7/8 Agonists
De Vrieze, Jana, Louage, Benoit, Deswarte, Kim, Zhong, Zifu, De Coen, Ruben, Van Herck, Simon, Nuhn, Lutz, Kaas Frich, Camilla, Zelikin, Alexander N., Lienenklaus, Stefan, Sanders, Niek N., Lambrecht, Bart N., David, Sunil A., De Geest, Bruno G.
Published in Angewandte Chemie International Edition (21.10.2019)
Published in Angewandte Chemie International Edition (21.10.2019)
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Lymph-Node-Targeted Immune Activation by Engineered Block Copolymer Amphiphiles–TLR7/8 Agonist Conjugates
Van Herck, Simon, Deswarte, Kim, Nuhn, Lutz, Zhong, Zifu, Portela Catani, Joao Paulo, Li, Yupeng, Sanders, Niek N, Lienenklaus, Stefan, De Koker, Stefaan, Lambrecht, Bart N, David, Sunil A, De Geest, Bruno G
Published in Journal of the American Chemical Society (31.10.2018)
Published in Journal of the American Chemical Society (31.10.2018)
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Control over Imidazoquinoline Immune Stimulation by pH-Degradable Poly(norbornene) Nanogels
Kockelmann, Johannes, Stickdorn, Judith, Kasmi, Sabah, De Vrieze, Jana, Pieszka, Michaela, Ng, David Yuen W, David, Sunil A, De Geest, Bruno G, Nuhn, Lutz
Published in Biomacromolecules (08.06.2020)
Published in Biomacromolecules (08.06.2020)
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Lipid-Polyglutamate Nanoparticle Vaccine Platform
Van Lysebetten, Dorien, Malfanti, Alessio, Deswarte, Kim, Koynov, Kaloian, Golba, Bianka, Ye, Tingting, Zhong, Zifu, Kasmi, Sabah, Lamoot, Alexander, Chen, Yong, Van Herck, Simon, Lambrecht, Bart N, Sanders, Niek N, Lienenklaus, Stefan, David, Sunil A, Vicent, María J, De Koker, Stefaan, De Geest, Bruno G
Published in ACS applied materials & interfaces (10.02.2021)
Published in ACS applied materials & interfaces (10.02.2021)
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Structure–Activity Relationships in Human Toll-like Receptor 8‑Active 2,3-Diamino-furo[2,3‑c]pyridines
Salunke, Deepak B, Yoo, Euna, Shukla, Nikunj M, Balakrishna, Rajalakshmi, Malladi, Subbalakshmi S, Serafin, Katelyn J, Day, Victor W, Wang, Xinkun, David, Sunil A
Published in Journal of medicinal chemistry (27.09.2012)
Published in Journal of medicinal chemistry (27.09.2012)
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Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure–Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
Yoo, Euna, Salunke, Deepak B, Sil, Diptesh, Guo, Xiaoqiang, Salyer, Alex C. D, Hermanson, Alec R, Kumar, Manoj, Malladi, Subbalakshmi S, Balakrishna, Rajalakshmi, Thompson, Ward H, Tanji, Hiromi, Ohto, Umeharu, Shimizu, Toshiyuki, David, Sunil A
Published in Journal of medicinal chemistry (09.10.2014)
Published in Journal of medicinal chemistry (09.10.2014)
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