Preclinical Development of a Bispecific Antibody that Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia
Buatois, Vanessa, Johnson, Zoë, Salgado-Pires, Susana, Papaioannou, Anne, Hatterer, Eric, Chauchet, Xavier, Richard, Françoise, Barba, Leticia, Daubeuf, Bruno, Cons, Laura, Broyer, Lucile, D'Asaro, Matilde, Matthes, Thomas, LeGallou, Simon, Fest, Thierry, Tarte, Karin, Clarke Hinojosa, Robert K, Genescà Ferrer, Eulàlia, Ribera, José María, Dey, Aditi, Bailey, Katharine, Fielding, Adele K, Eissenberg, Linda, Ritchey, Julie, Rettig, Michael, DiPersio, John F, Kosco-Vilbois, Marie H, Masternak, Krzysztof, Fischer, Nicolas, Shang, Limin, Ferlin, Walter G
Published in Molecular cancer therapeutics (01.08.2018)
Published in Molecular cancer therapeutics (01.08.2018)
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Journal Article
Targeting CEACAM5-positive solid tumors using NILK-2401, a novel CEACAM5xCD47 κλ bispecific antibody
Seckinger, Anja, Buatois, Vanessa, Moine, Valéry, Daubeuf, Bruno, Richard, Françoise, Chatel, Laurence, Viandier, Alizée, Bosson, Nicolas, Rousset, Emeline, Masternak, Krzysztof, Salgado-Pires, Susana, Batista, Claudia, Mougin, Christelle, Juan-Bégeot, Flora, Poitevin, Yves, Hose, Dirk
Published in Frontiers in immunology (24.04.2024)
Published in Frontiers in immunology (24.04.2024)
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Development and characterization of NILK-2301, a novel CEACAM5xCD3 κλ bispecific antibody for immunotherapy of CEACAM5-expressing cancers
Seckinger, Anja, Majocchi, Sara, Moine, Valéry, Nouveau, Lise, Ngoc, Hoang, Daubeuf, Bruno, Ravn, Ulla, Pleche, Nicolas, Calloud, Sebastien, Broyer, Lucile, Cons, Laura, Lesnier, Adeline, Chatel, Laurence, Papaioannou, Anne, Salgado-Pires, Susana, Krämer, Sebastian, Gockel, Ines, Lordick, Florian, Masternak, Krzysztof, Poitevin, Yves, Magistrelli, Giovanni, Malinge, Pauline, Shang, Limin, Kallendrusch, Sonja, Strein, Klaus, Hose, Dirk
Published in Journal of hematology and oncology (12.12.2023)
Published in Journal of hematology and oncology (12.12.2023)
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Journal Article
CD47xCD19 bispecific antibody triggers recruitment and activation of innate immune effector cells in a B-cell lymphoma xenograft model
Chauchet, Xavier, Cons, Laura, Chatel, Laurence, Daubeuf, Bruno, Didelot, Gérard, Moine, Valéry, Chollet, Didier, Malinge, Pauline, Pontini, Guillemette, Masternak, Krzysztof, Ferlin, Walter, Buatois, Vanessa, Shang, Limin
Published in Experimental hematology & oncology (10.05.2022)
Published in Experimental hematology & oncology (10.05.2022)
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Journal Article
TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock
Daubeuf, Bruno, Mathison, John, Spiller, Stephan, Hugues, Stephanie, Herren, Suzanne, Ferlin, Walter, Kosco-Vilbois, Marie, Wagner, Hermann, Kirschning, Carsten J, Ulevitch, Richard, Elson, Greg
Published in The Journal of immunology (1950) (01.11.2007)
Published in The Journal of immunology (1950) (01.11.2007)
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Journal Article
Characterization of a surrogate murine antibody to model anti-human CD3 therapies
Dépis, Fabien, Hatterer, Eric, Ballet, Romain, Daubeuf, Bruno, Cons, Laura, Glatt, Sophie, Reith, Walter, Kosco-Vilbois, Marie, Dean, Yann
Published in mAbs (01.07.2013)
Published in mAbs (01.07.2013)
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Journal Article
Co-engaging CD47 and CD19 with a bispecific antibody abrogates B-cell receptor/CD19 association leading to impaired B-cell proliferation
Hatterer, Eric, Barba, Leticia, Noraz, Nelly, Daubeuf, Bruno, Aubry-Lachainaye, Jean-Pierre, von der Weid, Benoit, Richard, Françoise, Kosco-Vilbois, Marie, Ferlin, Walter, Shang, Limin, Buatois, Vanessa
Published in mAbs (17.02.2019)
Published in mAbs (17.02.2019)
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Journal Article
TLR4-induced IFN-gamma production increases TLR2 sensitivity and drives Gram-negative sepsis in mice
Spiller, Stephan, Elson, Greg, Ferstl, Ruth, Dreher, Stefan, Mueller, Thomas, Freudenberg, Marina, Daubeuf, Bruno, Wagner, Hermann, Kirschning, Carsten J
Published in The Journal of experimental medicine (04.08.2008)
Published in The Journal of experimental medicine (04.08.2008)
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Journal Article
Development and characterization of NILK-2301, a novel CEACAM5xCD3 κ[lambda] bispecific antibody for immunotherapy of CEACAM5-expressing cancers
Seckinger, Anja, Majocchi, Sara, Moine, Valéry, Nouveau, Lise, Ngoc, Hoang, Daubeuf, Bruno, Ravn, Ulla, Pleche, Nicolas, Calloud, Sebastien, Broyer, Lucile, Cons, Laura, Lesnier, Adeline, Chatel, Laurence, Papaioannou, Anne, Salgado-Pires, Susana, Krämer, Sebastian, Gockel, Ines, Lordick, Florian, Masternak, Krzysztof, Poitevin, Yves, Magistrelli, Giovanni, Malinge, Pauline, Shang, Limin, Kallendrusch, Sonja, Strein, Klaus, Hose, Dirk
Published in Journal of hematology and oncology (12.12.2023)
Published in Journal of hematology and oncology (12.12.2023)
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Journal Article
A specific anti-citrullinated protein antibody profile identifies a group of rheumatoid arthritis patients with a toll-like receptor 4-mediated disease
Hatterer, Eric, Shang, Limin, Simonet, Pierre, Herren, Suzanne, Daubeuf, Bruno, Teixeira, Stéphanie, Reilly, James, Elson, Greg, Nelson, Robert, Gabay, Cem, Sokolove, Jeremy, McInnes, Iain B, Kosco-Vilbois, Marie, Ferlin, Walter, Monnet, Emmanuel, De Min, Cristina
Published in Arthritis research & therapy (06.10.2016)
Published in Arthritis research & therapy (06.10.2016)
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Journal Article
Abstract 5293: Preclinical development of NI-3201, a PD-L1xCD28 bispecific antibody mediating CD28 costimulation upon PD-L1 blockade
Majocchi, Sara, Anceriz, Nadia, Viandier, Alizée, Lesnier, Adeline, Cons, Laura, Nouveau, Lise, Pace, Emily A., Millard, Bjorn L., Daubeuf, Bruno, Moine, Valéry, Salgado-Pires, Susana, Saro, José, Shang, Limin, Masternak, Krzysztof, Ferlin, Walter G.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Selective Antibody Intervention of Toll-like Receptor 4 Activation through Fc γ Receptor Tethering
Shang, Limin, Daubeuf, Bruno, Triantafilou, Martha, Olden, Robin, Dépis, Fabien, Raby, Anne-Catherine, Herren, Suzanne, Dos Santos, Anaelle, Malinge, Pauline, Dunn-Siegrist, Irene, Benmkaddem, Sanae, Geinoz, Antoine, Magistrelli, Giovanni, Rousseau, François, Buatois, Vanessa, Salgado-Pires, Susana, Reith, Walter, Monteiro, Renato, Pugin, Jérôme, Leger, Olivier, Ferlin, Walter, Kosco-Vilbois, Marie, Triantafilou, Kathy, Elson, Greg
Published in The Journal of biological chemistry (30.05.2014)
Published in The Journal of biological chemistry (30.05.2014)
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Journal Article
Abstract 5100: Combination of κλ bispecific antibodies targeting innate (CEAxCD47, NILK-2401) and adaptive immunity (CEAxCD3, NILK-2301 and CEAxCD28, NILK-3301) for next generation immunotherapy of CEA-expressing cancers
Seckinger, Anja, Nouveau, Lise, Majocchi, Sara, Moine, Valéry, Buatois, Vanessa, Daubeuf, Bruno, Gueneau, Franck, Ravn, Ulla, Masternak, Krzysztof, Poitevin, Yves, Rousset, Emeline, Magistrelli, Giovanni, Malinge, Pauline, Shang, Limin, Fischer, Nicolas, Strein, Klaus, Ferlin, Walter, Hose, Dirk
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Enhancement of islet engraftment and achievement of long-term islet allograft survival by Toll-like receptor 4 blockade
Giovannoni, Laurianne, Muller, Yannick D, Lacotte, Stéphanie, Parnaud, Géraldine, Borot, Sophie, Meier, Raphaël P H, Lavallard, Vanessa, Bédat, Benoît, Toso, Christian, Daubeuf, Bruno, Elson, Greg, Shang, Limin, Morel, Philippe, Kosco-Vilbois, Marie, Bosco, Domenico, Berney, Thierry
Published in Transplantation (01.01.2015)
Published in Transplantation (01.01.2015)
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Abstract 2951: NI-2901, an affinity-optimized CD47xPD-L1 bispecific antibody for dual immune checkpoint blockade
Chauchet, Xavier, Calloud, Sebastien, LLoveras, Pauline, Bosson, Nicolas, Legrand, Margaux, Chatel, Laurence, Cons, Laura, Lesnier, Adeline, Malinge, Pauline, Pontini, Guillemette, Guillamo, Christophe, Shchelokov, Dmitry, Demin, Oleg, Ravn, Ulla, Moine, Valéry, Daubeuf, Bruno, Magistrelli, Giovanni, Poitevin, Yves, Salgado-Pires, Susana, Shang, Limin, Fischer, Nicolas, Ferlin, Walter, Masternak, Krzysztof
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Pivotal Involvement of Fcγ Receptor IIA in the Neutralization of Lipopolysaccharide Signaling via a Potent Novel Anti-TLR4 Monoclonal Antibody 15C1
Dunn-Siegrist, Irene, Leger, Olivier, Daubeuf, Bruno, Poitevin, Yves, Dépis, Fabien, Herren, Suzanne, Kosco-Vilbois, Marie, Dean, Yann, Pugin, Jérôme, Elson, Greg
Published in The Journal of biological chemistry (30.11.2007)
Published in The Journal of biological chemistry (30.11.2007)
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Journal Article
Bispecific antibody targeting of CD47/CD19 to promote enhanced phagocytosis of patient B lymphoma cells
Johnson, Zoe, Papaioannou, Anne, Bernard, Lucie, Cosimo, Emilio, Daubeuf, Bruno, Richard, Francoise, Chauchet, Xavier, Moine, Valery, Broyer, Lucile, Shang, Limin, Deehan, Maureen, Fischer, Nicolas, Masternak, Krzysztof, Kosco-Vilbois, Marie, Michie, Alison, Ferlin, Walter
Published in Journal of clinical oncology (20.05.2015)
Published in Journal of clinical oncology (20.05.2015)
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Journal Article
Abstract 3428: NI-2901, a CD47xPD-L1 bispecific antibody for dual immune checkpoint blockade with fine-tuned affinity to reduce erythrocyte binding and improve biodistribution
Chauchet, Xavier, Calloud, Sébastien, Legrand, Margaux, Cons, Laura, Chatel, Laurence, Lloveras, Pauline, Burnet-Merlin, Coline, Hellequin, Louis, Bosson, Nicolas, Malinge, Pauline, Pleche, Nicolas, Bourguignon, Jérémie, Pontini, Guillemette, Guillamo, Christophe, Ravn, Ulla, Moine, Valéry, Daubeuf, Bruno, Poitevin, Yves, Magistrelli, Giovanni, Shang, Limin, Ferlin, Walter, Masternak, Krzysztof
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Robust recombinant FcRn production in mammalian cells enabling oriented immobilization for IgG binding studies
Magistrelli, Giovanni, Malinge, Pauline, Anceriz, Nadia, Desmurs, Marjorie, Venet, Sophie, Calloud, Sébastien, Daubeuf, Bruno, Kosco-Vilbois, Marie, Fischer, Nicolas
Published in Journal of immunological methods (31.01.2012)
Published in Journal of immunological methods (31.01.2012)
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