Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo
Kuhn, A N, Diken, M, Kreiter, S, Selmi, A, Kowalska, J, Jemielity, J, Darzynkiewicz, E, Huber, C, Türeci, Ö, Sahin, U
Published in Gene therapy (01.08.2010)
Published in Gene therapy (01.08.2010)
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Journal Article
Synthetic m 3 G-CAP attachment necessitates a minimum trinucleotide constituent to be recognised as a nuclear import signal
Honcharenko, M., Bestas, B., Jezowska, M., Wojtczak, B. A., Moreno, P. M. D., Romanowska, J., Bächle, S. M., Darzynkiewicz, E., Jemielity, J., Smith, C. I. E., Strömberg, R.
Published in RSC advances (2016)
Published in RSC advances (2016)
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Journal Article
Weak binding affinity of human 4EHP for mRNA cap analogs
Zuberek, Joanna, Kubacka, Dorota, Jablonowska, Agnieszka, Jemielity, Jacek, Stepinski, Janusz, Sonenberg, Nahum, Darzynkiewicz, Edward
Published in RNA (Cambridge) (01.05.2007)
Published in RNA (Cambridge) (01.05.2007)
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Journal Article
Stopped-flow and Brownian dynamics studies of electrostatic effects in the kinetics of binding of 7-methyl-GpppG to the protein eIF4E
Błachut-Okrasińska, E, Bojarska, E, Niedźwiecka, A, Chlebicka, L, Darzynkiewicz, E, Stolarski, R, St piński, J, Antosiewicz, J M
Published in European biophysics journal (01.01.2000)
Published in European biophysics journal (01.01.2000)
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Journal Article
Kinetics of C. Elegans DcpS Cap Hydrolysis Studied by Fluorescence Spectroscopy
Wierzchowski, J., Pietrzak, M., Stepinski, J., Jemielity, J., Kalek, M., Bojarska, E., Jankowska-Anyszka, M., Davis, R. E., Darzynkiewicz, E.
Published in Nucleosides, nucleotides & nucleic acids (01.01.2007)
Published in Nucleosides, nucleotides & nucleic acids (01.01.2007)
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Journal Article
Synthesis and properties of mRNAs containing the novel “anti-reverse” cap analogs 7-methyl(3′-O-methyl)GpppG and 7-methyl(3′-deoxy)GpppG
STEPINSKI, JANUSZ, WADDELL, CLINT, STOLARSKI, RYSZARD, DARZYNKIEWICZ, EDWARD, RHOADS, ROBERT E.
Published in RNA (Cambridge) (01.10.2001)
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Published in RNA (Cambridge) (01.10.2001)
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Purine nucleoside phosphorylase. Structure-activity relationships for substrate and inhibitor properties of N-1-, N-7-, and C-8-substituted analogues; differentiation of mammalian and bacterial enzymes with N-1-methylinosine and guanosine
Bzowska, A, Kulikowska, E, Darzynkiewicz, E, Shugar, D
Published in The Journal of biological chemistry (05.07.1988)
Published in The Journal of biological chemistry (05.07.1988)
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Journal Article
Molecular recognition of mRNA 5′ cap by 3′ poly(A)-specific ribonuclease (PARN) differs from interactions known for other cap-binding proteins
Niedzwiecka, Anna, Nilsson, Per, Worch, Remigiusz, Stepinski, Janusz, Darzynkiewicz, Edward, Virtanen, Anders
Published in Biochimica et biophysica acta (01.04.2016)
Published in Biochimica et biophysica acta (01.04.2016)
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Journal Article
Novel "anti-reverse" cap analogs with superior translational properties
Jemielity, Jacek, Fowler, Tolvert, Zuberek, Joanna, Stepinski, Janusz, Lewdorowicz, Magdalena, Niedzwiecka, Anna, Stolarski, Ryszard, Darzynkiewicz, Edward, Rhoads, Robert E
Published in RNA (Cambridge) (01.09.2003)
Published in RNA (Cambridge) (01.09.2003)
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Journal Article
Biophysical Studies of eIF4E Cap-binding Protein: Recognition of mRNA 5′ Cap Structure and Synthetic Fragments of eIF4G and 4E-BP1 Proteins
Niedzwiecka, Anna, Marcotrigiano, Joseph, Stepinski, Janusz, Jankowska-Anyszka, Marzena, Wyslouch-Cieszynska, Aleksandra, Dadlez, Michal, Gingras, Anne-Claude, Mak, Pawel, Darzynkiewicz, Edward, Sonenberg, Nahum, Burley, Stephen K., Stolarski, Ryszard
Published in Journal of molecular biology (07.06.2002)
Published in Journal of molecular biology (07.06.2002)
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Journal Article
mRNAs containing the histone 3' stem-loop are degraded primarily by decapping mediated by oligouridylation of the 3' end
Su, Wei, Slepenkov, Sergey V, Slevin, Michael K, Lyons, Shawn M, Ziemniak, Marcin, Kowalska, Joanna, Darzynkiewicz, Edward, Jemielity, Jacek, Marzluff, William F, Rhoads, Robert E
Published in RNA (Cambridge) (01.01.2013)
Published in RNA (Cambridge) (01.01.2013)
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Journal Article
Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation
Wojtczak, Blazej A, Warminski, Marcin, Kowalska, Joanna, Lukaszewicz, Maciej, Honcharenko, Malgorzata, Smith, CIEdvard, Stromberg, Roger, Darzynkiewicz, Edward, Jemielity, Jacek
Published in RSC advances (01.01.2016)
Published in RSC advances (01.01.2016)
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Journal Article
Differential Inhibition of mRNA Degradation Pathways by Novel Cap Analogs
Grudzien, Ewa, Kalek, Marcin, Jemielity, Jacek, Darzynkiewicz, Edward, Rhoads, Robert E.
Published in The Journal of biological chemistry (27.01.2006)
Published in The Journal of biological chemistry (27.01.2006)
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Journal Article
Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract
Honcharenko, Malgorzata, Zytek, Malgorzata, Bestas, Burcu, Moreno, Pedro, Jemielity, Jacek, Darzynkiewicz, Edward, Smith, C.I. Edvard, Strömberg, Roger
Published in Bioorganic & medicinal chemistry (15.12.2013)
Published in Bioorganic & medicinal chemistry (15.12.2013)
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Journal Article
Thermodynamics of mRNA 5‘ Cap Binding by Eukaryotic Translation Initiation Factor eIF4E
Niedzwiecka, Anna, Darzynkiewicz, Edward, Stolarski, Ryszard
Published in Biochemistry (Easton) (26.10.2004)
Published in Biochemistry (Easton) (26.10.2004)
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Journal Article
Influence of Electric Charge Variation at Residues 209 and 159 on the Interaction of eIF4E with the mRNA 5‘ Terminus
Zuberek, Joanna, Jemielity, Jacek, Jablonowska, Agnieszka, Stepinski, Janusz, Dadlez, Michał, Stolarski, Ryszard, Darzynkiewicz, Edward
Published in Biochemistry (Easton) (11.05.2004)
Published in Biochemistry (Easton) (11.05.2004)
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Journal Article
Specificity of recognition of mRNA 5' cap by human nuclear cap-binding complex
Worch, Remigiusz, Niedzwiecka, Anna, Stepinski, Janusz, Mazza, Catherine, Jankowska-Anyszka, Marzena, Darzynkiewicz, Edward, Cusack, Stephen, Stolarski, Ryszard
Published in RNA (Cambridge) (01.09.2005)
Published in RNA (Cambridge) (01.09.2005)
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