Cardiac Late Sodium Channel Current Is a Molecular Target for the Sodium/Glucose Cotransporter 2 Inhibitor Empagliflozin
Philippaert, Koenraad, Kalyaanamoorthy, Subha, Fatehi, Mohammad, Long, Wentong, Soni, Shubham, Byrne, Nikole J, Barr, Amy, Singh, Jyoti, Wong, Jordan, Palechuk, Taylor, Schneider, Chloe, Darwesh, Ahmed M, Maayah, Zaid H, Seubert, John M, Barakat, Khaled, Dyck, Jason R B, Light, Peter E
Published in Circulation (New York, N.Y.) (01.06.2021)
Published in Circulation (New York, N.Y.) (01.06.2021)
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Journal Article
Genetic Deletion or Pharmacological Inhibition of Soluble Epoxide Hydrolase Ameliorates Cardiac Ischemia/Reperfusion Injury by Attenuating NLRP3 Inflammasome Activation
Darwesh, Ahmed M, Keshavarz-Bahaghighat, Hedieh, Jamieson, K Lockhart, Seubert, John M
Published in International journal of molecular sciences (17.07.2019)
Published in International journal of molecular sciences (17.07.2019)
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Journal Article
Insulin directly stimulates mitochondrial glucose oxidation in the heart
Karwi, Qutuba G, Wagg, Cory S, Altamimi, Tariq R, Uddin, Golam M, Ho, Kim L, Darwesh, Ahmed M, Seubert, John M, Lopaschuk, Gary D
Published in Cardiovascular diabetology (07.12.2020)
Published in Cardiovascular diabetology (07.12.2020)
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Journal Article
Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism
Altamimi, Tariq R, Thomas, Panakkezhum D, Darwesh, Ahmed M, Fillmore, Natasha, Mahmoud, Mohammad U, Zhang, Liyan, Gupta, Abhishek, Al Batran, Rami, Seubert, John M, Lopaschuk, Gary D
Published in Biochemical journal (15.03.2018)
Published in Biochemical journal (15.03.2018)
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Journal Article
A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3-NLRP3 Pathway
Darwesh, Ahmed M, Bassiouni, Wesam, Adebesin, Adeniyi Michael, Mohammad, Abdul Sattar, Falck, John R, Seubert, John M
Published in International journal of molecular sciences (24.07.2020)
Published in International journal of molecular sciences (24.07.2020)
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Journal Article
Loss of PI3Kα Mediates Protection From Myocardial Ischemia-Reperfusion Injury Linked to Preserved Mitochondrial Function
Zhabyeyev, Pavel, McLean, Brent, Bassiouni, Wesam, Valencia, Robert, Paul, Manish, Darwesh, Ahmed M, Seubert, John M, Hazra, Saugata, Oudit, Gavin Y
Published in Journal of the American Heart Association (20.06.2023)
Published in Journal of the American Heart Association (20.06.2023)
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Journal Article
Soluble Epoxide Hydrolase in Aged Female Mice and Human Explanted Hearts Following Ischemic Injury
Jamieson, K Lockhart, Darwesh, Ahmed M, Sosnowski, Deanna K, Zhang, Hao, Shah, Saumya, Zhabyeyev, Pavel, Yang, Jun, Hammock, Bruce D, Edin, Matthew L, Zeldin, Darryl C, Oudit, Gavin Y, Kassiri, Zamaneh, Seubert, John M
Published in International journal of molecular sciences (08.02.2021)
Published in International journal of molecular sciences (08.02.2021)
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Journal Article
Age and Sex Differences in Hearts of Soluble Epoxide Hydrolase Null Mice
Jamieson, K Lockhart, Keshavarz-Bahaghighat, Hedieh, Darwesh, Ahmed M, Sosnowski, Deanna K, Seubert, John M
Published in Frontiers in physiology (07.02.2020)
Published in Frontiers in physiology (07.02.2020)
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Journal Article
Deficiency of Soluble Epoxide Hydrolase Protects Cardiac Function Impaired by LPS-Induced Acute Inflammation
Samokhvalov, Victor, Jamieson, K Lockhart, Darwesh, Ahmed M, Keshavarz-Bahaghighat, Hedieh, Lee, Tim Y T, Edin, Matthew, Lih, Fred, Zeldin, Darryl C, Seubert, John M
Published in Frontiers in pharmacology (14.01.2019)
Published in Frontiers in pharmacology (14.01.2019)
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Journal Article
Changes in the Left Ventricular Eicosanoid Profile in Human Dilated Cardiomyopathy
Sosnowski, Deanna K, Jamieson, K Lockhart, Darwesh, Ahmed M, Zhang, Hao, Keshavarz-Bahaghighat, Hedieh, Valencia, Robert, Viveiros, Anissa, Edin, Matthew L, Zeldin, Darryl C, Oudit, Gavin Y, Seubert, John M
Published in Frontiers in cardiovascular medicine (19.05.2022)
Published in Frontiers in cardiovascular medicine (19.05.2022)
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Journal Article
Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?
Darwesh, Ahmed M., Bassiouni, Wesam, Sosnowski, Deanna K., Seubert, John M.
Published in Pharmacology & therapeutics (Oxford) (01.03.2021)
Published in Pharmacology & therapeutics (Oxford) (01.03.2021)
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Journal Article
Cytochrome P450-derived eicosanoids and heart function
Jamieson, K Lockhart, Endo, Tomoko, Darwesh, Ahmed M, Samokhvalov, Victor, Seubert, John M
Published in Pharmacology & therapeutics (Oxford) (01.11.2017)
Published in Pharmacology & therapeutics (Oxford) (01.11.2017)
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Journal Article
Cardioprotective properties of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids
Kranrod, Joshua, Konkel, Anne, Valencia, Robert, Darwesh, Ahmed M., Fischer, Robert, Schunck, Wolf-Hagen, Seubert, John M.
Published in The Journal of biological chemistry (01.06.2024)
Published in The Journal of biological chemistry (01.06.2024)
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Journal Article
Empagliflozin Blunts Worsening Cardiac Dysfunction Associated With Reduced NLRP3 (Nucleotide-Binding Domain-Like Receptor Protein 3) Inflammasome Activation in Heart Failure
Byrne, Nikole J, Matsumura, Nobutoshi, Maayah, Zaid H, Ferdaoussi, Mourad, Takahara, Shingo, Darwesh, Ahmed M, Levasseur, Jody L, Jahng, James Won Suk, Vos, Dyonne, Parajuli, Nirmal, El-Kadi, Ayman O S, Braam, Branko, Young, Martin E, Verma, Subodh, Light, Peter E, Sweeney, Gary, Seubert, John M, Dyck, Jason R B
Published in Circulation. Heart failure (01.01.2020)
Published in Circulation. Heart failure (01.01.2020)
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Journal Article
Insights into the cardioprotective properties of n-3 PUFAs against ischemic heart disease via modulation of the innate immune system
Darwesh, Ahmed M., Sosnowski, Deanna K., Lee, Tim YT, Keshavarz-Bahaghighat, Hedieh, Seubert, John M.
Published in Chemico-biological interactions (01.08.2019)
Published in Chemico-biological interactions (01.08.2019)
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Journal Article
Chronically Elevating Circulating Ketones Can Reduce Cardiac Inflammation and Blunt the Development of Heart Failure
Byrne, Nikole J., Soni, Shubham, Takahara, Shingo, Ferdaoussi, Mourad, Al Batran, Rami, Darwesh, Ahmed M., Levasseur, Jody L., Beker, Donna, Vos, Dyonne Y., Schmidt, Mya A., Alam, Abrar S., Maayah, Zaid H., Schertzer, Jonathan D., Seubert, John M., Ussher, John R., Dyck, Jason R.B.
Published in Circulation. Heart failure (01.06.2020)
Published in Circulation. Heart failure (01.06.2020)
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Journal Article
Cardioprotective effects of CYP-derived epoxy metabolites of docosahexaenoic acid involve limiting NLRP3 inflammasome activation
Darwesh, Ahmed M, Jamieson, K. Lockhart, Wang, Chuying, Samokhvalov, Victor, Seubert, John M
Published in Canadian journal of physiology and pharmacology (01.06.2019)
Published in Canadian journal of physiology and pharmacology (01.06.2019)
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Journal Article
Cardioprotective Action of a Novel Synthetic 19,20-EDP Analog Is Sirt Dependent
Kranrod, Joshua W, Darwesh, Ahmed M, Bassiouni, Wesam, Huang, Andy, Fang, Liye, Korodimas, Jacob V, Adebesin, Adeniyi Michael, Munnuri, Sailu, Falck, John R, Seubert, John M
Published in Journal of cardiovascular pharmacology (01.01.2024)
Published in Journal of cardiovascular pharmacology (01.01.2024)
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Journal Article
Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis
Gopal, Keshav, Abdualkader, Abdualrahman Mohammed, Li, Xiaobei, Greenwell, Amanda A., Karwi, Qutuba G., Altamimi, Tariq R., Saed, Christina, Uddin, Golam M., Darwesh, Ahmed M., Jamieson, K. Lockhart, Kim, Ryekjang, Eaton, Farah, Seubert, John M., Lopaschuk, Gary D., Ussher, John R., Al Batran, Rami
Published in The Journal of biological chemistry (01.12.2023)
Published in The Journal of biological chemistry (01.12.2023)
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