RGX-019-MMAE, a novel MERTK-targeting antibody-drug conjugate (ADC) with robust anti-tumor efficacy in both solid and liquid tumors
Takeda, Shugaku, Lo, PuiChi, Schefer, Daniel, Andreu-Agullo, Celia, Battula, Venkata Lokesh, Maiti, Abhishek, Tavazoie, Masoud, Darst, David Martin, Kurth, Isabel
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Phase 1b study of RGX-202-01, a first-in-class oral inhibitor of the SLC6A8/CKB pathway, in combination with FOLFIRI and bevacizumab (BEV) in second-line advanced colorectal cancer (CRC)
Hendifar, Andrew Eugene, Rosen, Lee S., Cercek, Andrea, McRee, Autumn Jackson, Basu Mallick, Atrayee, Spigel, David R., Tavazoie, Sohail F, Rowinsky, Eric Keith, Szarek, Michael, Gonsalves, Foster, Kurth, Isabel, Andreu, Celia, Busby, Robert, Spector, Scott, Darst, David Martin, Lebaka, Narayan, Bechar, Naftali, Tavazoie, Masoud, Wasserman, Robert, Fakih, Marwan
Published in Journal of clinical oncology (01.06.2022)
Published in Journal of clinical oncology (01.06.2022)
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Abstract B122: 2 for 1: Targeting tumor-associated macrophages and cancer cells with a novel MERTK-targeting antibody-drug conjugate (ADC)
Takeda, Shugaku, Lo, PuiChi, Schefer, Daniel, Siddiqui, Maryam, Tyagi, Anudishi, Battula, Venkata Lokesh, Maiti, Abhishek, Tavazoie, Sohail, Tavazoie, Masoud, Darst, David Martin, Kurth, Isabel
Published in Molecular cancer therapeutics (01.12.2023)
Published in Molecular cancer therapeutics (01.12.2023)
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Phase I monotherapy dose escalation of RGX-202, a first-in-class oral inhibitor of the SLC6a8/CKB pathway, in patients with advanced gastrointestinal (GI) solid tumors
Bendell, Johanna C., Strauss, James Fredric, Fakih, Marwan, McRee, Autumn Jackson, Hendifar, Andrew Eugene, Rosen, Lee S., Cercek, Andrea, Rowinsky, Eric Keith, Szarek, Michael, Gonsalves, Foster, Kurth, Isabel, Andreu, Celia, Busby, Robert, Spector, Scott, Darst, David Martin, Tavazoie, Masoud, Raza, Syed, Lebaka, Narayan, Wasserman, Robert, Janjigian, Yelena Yuriy
Published in Journal of clinical oncology (20.05.2020)
Published in Journal of clinical oncology (20.05.2020)
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Pharmacodynamic and clinical activity of RGX-104, a first-in-class immunotherapy targeting the liver-X nuclear hormone receptor (LXR), in patients with refractory malignancies
Mita, Monica M., Mita, Alain C., Chmielowski, Bartosz, Hamilton, Erika Paige, Pant, Shubham, Waltzman, Roger J., Rowinsky, Eric Keith, Szarek, Michael, Gonsalves, Foster, Kurth, Isabel, Andreu, Celia, Busby, Robert, Darst, David Martin, Tavazoie, Sohail S., Tavazoie, Masoud, Postow, Michael A.
Published in Journal of clinical oncology (20.05.2018)
Published in Journal of clinical oncology (20.05.2018)
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