Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2+ Breast Cancer
Alwarawrah, Yazan, Hughes, Philip, Loiselle, David, Carlson, David A., Darr, David B., Jordan, Jamie L., Xiong, Jessie, Hunter, Lucas M., Dubois, Laura G., Thompson, J. Will, Kulkarni, Manjusha M., Ratcliff, Annette N., Kwiek, Jesse J., Haystead, Timothy A.J.
Published in Cell chemical biology (23.06.2016)
Published in Cell chemical biology (23.06.2016)
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A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity
He, Zhijian, Wan, Xiaomeng, Schulz, Anita, Bludau, Herdis, Dobrovolskaia, Marina A, Stern, Stephan T, Montgomery, Stephanie A, Yuan, Hong, Li, Zibo, Alakhova, Daria, Sokolsky, Marina, Darr, David B, Perou, Charles M, Jordan, Rainer, Luxenhofer, Robert, Kabanov, Alexander V
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Dynamic Reprogramming of the Kinome in Response to Targeted MEK Inhibition in Triple-Negative Breast Cancer
Duncan, James S., Whittle, Martin C., Nakamura, Kazuhiro, Abell, Amy N., Midland, Alicia A., Zawistowski, Jon S., Johnson, Nancy L., Granger, Deborah A., Jordan, Nicole Vincent, Darr, David B., Usary, Jerry, Kuan, Pei-Fen, Smalley, David M., Major, Ben, He, Xiaping, Hoadley, Katherine A., Zhou, Bing, Sharpless, Norman E., Perou, Charles M., Kim, William Y., Gomez, Shawn M., Chen, Xin, Jin, Jian, Frye, Stephen V., Earp, H. Shelton, Graves, Lee M., Johnson, Gary L.
Published in Cell (13.04.2012)
Published in Cell (13.04.2012)
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Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy
ROBERTS, Patrick J, BISI, John E, STRUM, Jay C, COMBEST, Austin J, DARR, David B, USARY, Jerry E, ZAMBONI, William C, WONG, Kwok-Kin, PEROU, Charles M, SHARPLESS, Norman E
Published in JNCI : Journal of the National Cancer Institute (21.03.2012)
Published in JNCI : Journal of the National Cancer Institute (21.03.2012)
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New Mechanisms of Resistance to MEK Inhibitors in Melanoma Revealed by Intravital Imaging
Brighton, Hailey E, Angus, Steven P, Bo, Tao, Roques, Jose, Tagliatela, Alicia C, Darr, David B, Karagoz, Kubra, Sciaky, Noah, Gatza, Michael L, Sharpless, Norman E, Johnson, Gary L, Bear, James E
Published in Cancer research (Chicago, Ill.) (15.01.2018)
Published in Cancer research (Chicago, Ill.) (15.01.2018)
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A nanoparticle-incorporated STING activator enhances antitumor immunity in PD-L1-insensitive models of triple-negative breast cancer
Cheng, Ning, Watkins-Schulz, Rebekah, Junkins, Robert D, David, Clément N, Johnson, Brandon M, Montgomery, Stephanie A, Peine, Kevin J, Darr, David B, Yuan, Hong, McKinnon, Karen P, Liu, Qi, Miao, Lei, Huang, Leaf, Bachelder, Eric M, Ainslie, Kristy M, Ting, Jenny P-Y
Published in JCI insight (15.11.2018)
Published in JCI insight (15.11.2018)
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Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma
Burd, Christin E, Liu, Wenjin, Huynh, Minh V, Waqas, Meriam A, Gillahan, James E, Clark, Kelly S, Fu, Kailing, Martin, Brit L, Jeck, William R, Souroullas, George P, Darr, David B, Zedek, Daniel C, Miley, Michael J, Baguley, Bruce C, Campbell, Sharon L, Sharpless, Norman E
Published in Cancer discovery (01.12.2014)
Published in Cancer discovery (01.12.2014)
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Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex
Zawistowski, Jon S, Bevill, Samantha M, Goulet, Daniel R, Stuhlmiller, Timothy J, Beltran, Adriana S, Olivares-Quintero, Jose F, Singh, Darshan, Sciaky, Noah, Parker, Joel S, Rashid, Naim U, Chen, Xin, Duncan, James S, Whittle, Martin C, Angus, Steven P, Velarde, Sara Hanna, Golitz, Brian T, He, Xiaping, Santos, Charlene, Darr, David B, Gallagher, Kristalyn, Graves, Lee M, Perou, Charles M, Carey, Lisa A, Earp, H Shelton, Johnson, Gary L
Published in Cancer discovery (01.03.2017)
Published in Cancer discovery (01.03.2017)
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Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer
Tanioka, Maki, Mott, Kevin R, Hollern, Daniel P, Fan, Cheng, Darr, David B, Perou, Charles M
Published in Genome medicine (30.11.2018)
Published in Genome medicine (30.11.2018)
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The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor
Pfefferle, Adam D, Darr, David B, Calhoun, Benjamin C, Mott, Kevin R, Rosen, Jeffrey M, Perou, Charles M
Published in Disease models & mechanisms (01.07.2019)
Published in Disease models & mechanisms (01.07.2019)
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Obesity-mediated regulation of HGF/c-Met is associated with reduced basal-like breast cancer latency in parous mice
Sundaram, Sneha, Freemerman, Alex J, Galanko, Joseph A, McNaughton, Kirk K, Bendt, Katharine M, Darr, David B, Troester, Melissa A, Makowski, Liza
Published in PloS one (29.10.2014)
Published in PloS one (29.10.2014)
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Weight Loss Reversed Obesity-Induced HGF/c-Met Pathway and Basal-Like Breast Cancer Progression
Sundaram, Sneha, Le, Trinh L, Essaid, Luma, Freemerman, Alex J, Huang, Megan J, Galanko, Joseph A, McNaughton, Kirk K, Bendt, Katharine M, Darr, David B, Troester, Melissa A, Makowski, Liza
Published in Frontiers in oncology (08.07.2014)
Published in Frontiers in oncology (08.07.2014)
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Monitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model
Burd, Christin E, Sorrentino, Jessica A, Clark, Kelly S, Darr, David B, Krishnamurthy, Janakiraman, Deal, Allison M, Bardeesy, Nabeel, Castrillon, Diego H, Beach, David H, Sharpless, Norman E
Published in Cell (17.01.2013)
Published in Cell (17.01.2013)
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Coexistent ARID1A–PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling
Chandler, Ronald L., Damrauer, Jeffrey S., Raab, Jesse R., Schisler, Jonathan C., Wilkerson, Matthew D., Didion, John P., Starmer, Joshua, Serber, Daniel, Yee, Della, Xiong, Jessie, Darr, David B., de Villena, Fernando Pardo-Manuel, Kim, William Y., Magnuson, Terry
Published in Nature communications (27.01.2015)
Published in Nature communications (27.01.2015)
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Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy
Bhatt, Aadra P., Pellock, Samuel J., Biernat, Kristen A., Walton, William G., Wallace, Bret D., Creekmore, Benjamin C., Letertre, Marine M., Swann, Jonathan R., Wilson, Ian D., Roques, Jose R., Darr, David B., Bailey, Sean T., Montgomery, Stephanie A., Roach, Jeffrey M., Azcarate-Peril, M. Andrea, Sartor, R. Balfour, Gharaibeh, Raad Z., Bultman, Scott J., Redinbo, Matthew R.
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (31.03.2020)
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Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model
Burd, Christin E., Sorrentino, Jessica A., Clark, Kelly S., Darr, David B., Krishnamurthy, Janakiraman, Deal, Allison M., Bardeesy, Nabeel, Castrillon, Diego H., Beach, David H., Sharpless, Norman E.
Published in Cell (17.01.2013)
Published in Cell (17.01.2013)
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Poly(2-oxazoline) based micelles with high capacity for 3rd generation taxoids: Preparation, in vitro and in vivo evaluation
He, Zhijian, Schulz, Anita, Wan, Xiaomeng, Seitz, Joshua, Bludau, Herdis, Alakhova, Daria Y., Darr, David B., Perou, Charles M., Jordan, Rainer, Ojima, Iwao, Kabanov, Alexander V., Luxenhofer, Robert
Published in Journal of controlled release (28.06.2015)
Published in Journal of controlled release (28.06.2015)
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Docetaxel-Loaded PLGA Nanoparticles Improve Efficacy in Taxane-Resistant Triple-Negative Breast Cancer
Bowerman, Charles J, Byrne, James D, Chu, Kevin S, Schorzman, Allison N, Keeler, Amanda W, Sherwood, Candice A, Perry, Jillian L, Luft, James C, Darr, David B, Deal, Allison M, Napier, Mary E, Zamboni, William C, Sharpless, Norman E, Perou, Charles M, DeSimone, Joseph M
Published in Nano letters (11.01.2017)
Published in Nano letters (11.01.2017)
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Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research
Sigmon, John Sebastian, Blanchard, Matthew W, Baric, Ralph S, Bell, Timothy A, Brennan, Jennifer, Brockmann, Gudrun A, Burks, A Wesley, Calabrese, J Mauro, Caron, Kathleen M, Cheney, Richard E, Ciavatta, Dominic, Conlon, Frank, Darr, David B, Faber, James, Franklin, Craig, Gershon, Timothy R, Gralinski, Lisa, Gu, Bin, Gaines, Christiann H, Hagan, Robert S, Heimsath, Ernest G, Heise, Mark T, Hock, Pablo, Ideraabdullah, Folami, Jennette, J Charles, Kafri, Tal, Kashfeen, Anwica, Kulis, Mike, Kumar, Vivek, Linnertz, Colton, Livraghi-Butrico, Alessandra, Lloyd, K C Kent, Lutz, Cathleen, Lynch, Rachel M, Magnuson, Terry, Matsushima, Glenn K, McMullan, Rachel, Miller, Darla R, Mohlke, Karen L, Moy, Sheryl S, Murphy, Caroline E Y, Najarian, Maya, O’Brien, Lori, Palmer, Abraham A, Philpot, Benjamin D, Randell, Scott H, Reinholdt, Laura, Ren, Yuyu, Rockwood, Steve, Rogala, Allison R, Saraswatula, Avani, Sassetti, Christopher M, Schisler, Jonathan C, Schoenrock, Sarah A, Shaw, Ginger D, Shorter, John R, Smith, Clare M, St. Pierre, Celine L, Tarantino, Lisa M, Threadgill, David W, Valdar, William, Vilen, Barbara J, Wardwell, Keegan, Whitmire, Jason K, Williams, Lucy, Zylka, Mark J, Ferris, Martin T, McMillan, Leonard, Manuel de Villena, Fernando Pardo
Published in Genetics (Austin) (01.12.2020)
Published in Genetics (Austin) (01.12.2020)
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Identification of harmine and β-carboline analogs from a high-throughput screen of an approved drug collection; profiling as differential inhibitors of DYRK1A and monoamine oxidase A and for in vitro and in vivo anti-cancer studies
Tarpley, Michael, Oladapo, Helen O., Strepay, Dillon, Caligan, Thomas B., Chdid, Lhoucine, Shehata, Hassan, Roques, Jose R., Thomas, Rhashad, Laudeman, Christopher P., Onyenwoke, Rob U., Darr, David B., Williams, Kevin P.
Published in European journal of pharmaceutical sciences (01.07.2021)
Published in European journal of pharmaceutical sciences (01.07.2021)
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