Expression Profile of BCL-2, BCL-XL, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models
Punnoose, Elizabeth A, Leverson, Joel D, Peale, Franklin, Boghaert, Erwin R, Belmont, Lisa D, Tan, Nguyen, Young, Amy, Mitten, Michael, Ingalla, Ellen, Darbonne, Walter C, Oleksijew, Anatol, Tapang, Paul, Yue, Peng, Oeh, Jason, Lee, Leslie, Maiga, Sophie, Fairbrother, Wayne J, Amiot, Martine, Souers, Andrew J, Sampath, Deepak
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
Tian, Hua, Callahan, Christopher A, DuPree, Kelly J, Darbonne, Walter C, Ahn, Christina P, Scales, Suzie J, de Sauvage, Frederic J
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (17.03.2009)
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Potential mechanisms for thrombocytopenia development with trastuzumab emtansine (T-DM1)
Uppal, Hirdesh, Doudement, Estelle, Mahapatra, Kaushiki, Darbonne, Walter C, Bumbaca, Daniela, Shen, Ben-Quan, Du, Xiaoyan, Saad, Ola, Bowles, Kristin, Olsen, Steve, Lewis Phillips, Gail D, Hartley, Dylan, Sliwkowski, Mark X, Girish, Sandhya, Dambach, Donna, Ramakrishnan, Vanitha
Published in Clinical cancer research (01.01.2015)
Published in Clinical cancer research (01.01.2015)
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Phase I Trial of Hedgehog Pathway Inhibitor Vismodegib (GDC-0449) in Patients with Refractory, Locally Advanced or Metastatic Solid Tumors
LORUSSO, Patricia M, RUDIN, Charles M, GRAHAM, Richard A, ZERIVITZ, Kenn L, LOW, Jennifer A, VON HOFF, Daniel D, REDDY, Josina C, TIBES, Raoul, WEISS, Glen J, BORAD, Mitesh J, HANN, Christine L, BRAHMER, Julie R, CHANG, Ilsung, DARBONNE, Walter C
Published in Clinical cancer research (15.04.2011)
Published in Clinical cancer research (15.04.2011)
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Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma
Von Hoff, Daniel D, LoRusso, Patricia M, Rudin, Charles M, Reddy, Josina C, Yauch, Robert L, Tibes, Raoul, Weiss, Glen J, Borad, Mitesh J, Hann, Christine L, Brahmer, Julie R, Mackey, Howard M, Lum, Bertram L, Darbonne, Walter C, Marsters, James C, de Sauvage, Frederic J, Low, Jennifer A
Published in The New England journal of medicine (17.09.2009)
Published in The New England journal of medicine (17.09.2009)
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Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
Chen, Weiwei, Tang, Tracy, Eastham-Anderson, Jeff, Dunlap, Debra, Alicke, Bruno, Nannini, Michelle, Gould, Stephen, Yauch, Robert, Modrusan, Zora, DuPree, Kelly J, Darbonne, Walter C, Plowman, Greg, de Sauvage, Frederic J, Callahan, Christopher A
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Published in Proceedings of the National Academy of Sciences - PNAS (07.06.2011)
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A Phase I Study of DLYE5953A, an Anti-LY6E Antibody Covalently Linked to Monomethyl Auristatin E, in Patients with Refractory Solid Tumors
Tolaney, Sara M, Do, Khanh T, Eder, Joseph P, LoRusso, Patricia M, Weekes, Colin D, Chandarlapaty, Sarat, Chang, Ching-Wei, Chen, Shang-Chiung, Nazzal, Denise, Schuth, Eva, Brunstein, Flavia, Carrasco-Triguero, Montserrat, Darbonne, Walter C, Giltnane, Jennifer M, Flanagan, William M, Commerford, S Renee, Ungewickell, Alexander, Shapiro, Geoffrey I, Modi, Shanu
Published in Clinical cancer research (01.11.2020)
Published in Clinical cancer research (01.11.2020)
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A Phase I Dose-Escalation Study Evaluating the Safety Tolerability and Pharmacokinetics of CUDC-427, a Potent, Oral, Monovalent IAP Antagonist, in Patients with Refractory Solid Tumors
Tolcher, Anthony W, Bendell, Johanna C, Papadopoulos, Kyriakos P, Burris, Howard A, Patnaik, Amita, Fairbrother, Wayne J, Wong, Harvey, Budha, Nageshwar, Darbonne, Walter C, Peale, Franklin, Mamounas, Michael, Royer-Joo, Stephanie, Yu, Ron, Portera, Chia C, Infante, Jeffrey R
Published in Clinical cancer research (15.09.2016)
Published in Clinical cancer research (15.09.2016)
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A Phase Ib study evaluating MNRP1685A, a fully human anti-NRP1 monoclonal antibody, in combination with bevacizumab and paclitaxel in patients with advanced solid tumors
Patnaik, Amita, LoRusso, Patricia M., Messersmith, Wells A., Papadopoulos, Kyriakos P., Gore, Lia, Beeram, Muralidhar, Ramakrishnan, Vanitha, Kim, Amy H., Beyer, Joseph C., Mason Shih, L., Darbonne, Walter C., Xin, Yan, Yu, Ron, Xiang, Hong, Brachmann, Rainer K., Weekes, Colin D.
Published in Cancer chemotherapy and pharmacology (01.05.2014)
Published in Cancer chemotherapy and pharmacology (01.05.2014)
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Assessment of Clinical Response Following Atezolizumab and Bevacizumab Treatment in Patients With Neuroendocrine Tumors: A Nonrandomized Clinical Trial
Halperin, Daniel M, Liu, Suyu, Dasari, Arvind, Fogelman, David, Bhosale, Priya, Mahvash, Armeen, Estrella, Jeannelyn S, Rubin, Laura, Morani, Ajaykumar C, Knafl, Mark, Overeem, Tim A, Fu, Szu-Chin, Solis, Luisa M, Parra Cuentas, Edwin, Verma, Anuj, Chen, Hong-Lei, Gite, Swati, Subashchandrabose, Priya, Dervin, Shannon, Schulze, Katja, Darbonne, Walter C, Yun, Cindy, Wistuba, Ignacio I, Futreal, P Andrew, Woodman, Scott E, Yao, James C
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Published in JAMA oncology (01.06.2022)
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High-Throughput and Sensitive Quantification of Circulating Tumor DNA by Microfluidic-Based Multiplex PCR and Next-Generation Sequencing
Guan, Yinghui, Mayba, Oleg, Sandmann, Thomas, Lu, Shan, Choi, Younjeong, Darbonne, Walter C., Leveque, Vincent, Ryner, Lisa, Humke, Eric, Tam, Nga W.R., Sujathasarma, Sundari, Cheung, Anna, Bourgon, Richard, Lackner, Mark R., Wang, Yulei
Published in The Journal of molecular diagnostics : JMD (01.11.2017)
Published in The Journal of molecular diagnostics : JMD (01.11.2017)
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Learning and confirming with preclinical studies: modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist
Wong, Harvey, Gould, Stephen E, Budha, Nageshwar, Darbonne, Walter C, Kadel, 3rd, Edward E, La, Hank, Alicke, Bruno, Halladay, Jason S, Erickson, Rebecca, Portera, Chia, Tolcher, Anthony W, Infante, Jeffery R, Mamounas, Michael, Flygare, John A, Hop, Cornelis E C A, Fairbrother, Wayne J
Published in Drug metabolism and disposition (01.12.2013)
Published in Drug metabolism and disposition (01.12.2013)
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Abstract 4257: Gene expression and genomic drift comparative analysis between patient-derived conditionally reprogrammed cells and original tumors
Li, Jessica, Liu, Bonnie, Nakamura, Rin, Savage, Heidi, Ikeda, Shoji, Wilson, Timothy, Sumiyoshi, Teiko, Hampton, Garret, Amler, Lukas, Lackner, Mark, Huang, Shih-Min A., Darbonne, Walter C.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Antitherapeutic antibody-mediated hepatotoxicity of recombinant human Apo2L/TRAIL in the cynomolgus monkey
Zuch de Zafra, Christina L, Ashkenazi, Avi, Darbonne, Walter C, Cheu, Melissa, Totpal, Klara, Ortega, Shirley, Flores, Heather, Walker, Mark D, Kabakoff, Bruce, Lum, Bert L, Mounho-Zamora, Barbara J, Marsters, Scot A, Dybdal, Noël O
Published in Cell death & disease (11.08.2016)
Published in Cell death & disease (11.08.2016)
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Efficacy, Safety, and Biomarker Analysis of Combined PD-L1 (Atezolizumab) and VEGF (Bevacizumab) Blockade in Advanced Malignant Peritoneal Mesothelioma
Raghav, Kanwal, Liu, Suyu, Overman, Michael J, Willett, Anneleis F, Knafl, Mark, Fu, Szu-Chin, Malpica, Anais, Prasad, Seema, Royal, Richard E, Scally, Christopher P, Mansfield, Paul F, Wistuba, Ignacio I, Futreal, Andrew P, Maru, Dipen M, Solis Soto, Luisa M, Parra Cuentas, Edwin R, Chen, Honglei, Villalobos, Pamela, Verma, Anuj, Mahvash, Armeen, Hwu, Patrick, Cortazar, Patricia, McKenna, Edward, Yun, Cindy, Dervin, Shannon, Schulze, Katja, Darbonne, Walter C, Morani, Ajaykumar C, Kopetz, Scott, Fournier, Keith F, Woodman, Scott E, Yao, James C, Varadhachary, Gauri R, Halperin, Daniel M
Published in Cancer discovery (01.11.2021)
Published in Cancer discovery (01.11.2021)
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Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti‐CD40 antibody (SGN‐40) in rodents and non‐human primates
Kelley, Sean K, Gelzleichter, Thomas, Xie, Dong, Lee, Wyne P, Darbonne, Walter C, Qureshi, Ferhan, Kissler, Kim, Oflazoglu, Ezogelin, Grewal, Iqbal S
Published in British journal of pharmacology (01.08.2006)
Published in British journal of pharmacology (01.08.2006)
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Direct histological processing of EUS biopsies enables rapid molecular biomarker analysis for interventional pancreatic cancer trials
Brais, Rebecca J, Davies, Susan E, O’Donovan, Maria, Simpson, Ben W, Cook, Natalie, Darbonne, Walter C, Chilcott, Sian, Lolkema, Martijn P, Neesse, Albrecht, Lockley, Michelle, Corrie, Pippa G, Jodrell, Duncan I, Praseedom, Raaj K, Huguet, Emmanuel L, Jah, Asif, Jamieson, Neville V, de Sauvage, Frederic J, Tuveson, David A, Carroll, Nicholas R
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (2012)
Published in Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] (2012)
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Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysis
Wong, Harvey, Budha, Nageshwar R, West, Kristina, Blackwood, Elizabeth, Ware, Joseph A, Yu, Ron, Darbonne, Walter C, Gould, Stephen E, Steigerwalt, Ronald, Erickson, Rebecca, Hop, Cornelis E A C, LoRusso, Patricia, Eckhardt, S Gail, Wagner, Andrew, Chan, Iris T, Mamounas, Michael, Flygare, John A, Fairbrother, Wayne J
Published in Toxicological sciences (01.11.2012)
Published in Toxicological sciences (01.11.2012)
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Ischemic stroke injury is reduced in mice lacking a functional NADPH oxidase
Walder, C E, Green, S P, Darbonne, W C, Mathias, J, Rae, J, Dinauer, M C, Curnutte, J T, Thomas, G R
Published in Stroke (1970) (01.11.1997)
Published in Stroke (1970) (01.11.1997)
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Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand
de Sauvage, Frederic J, Hass, Philip E, Spencer, Susan D, Malloy, Beth E, Gurney, Austin L, Spencer, Steven A, Darbonne, Walter C, Henzel, William J, Wong, Suzy C, Kuang, Wun-Jing, Oles, Karl J, Hultgren, Bruce, Solberg, Lawrence A, Goeddel, David V, Eaton, Dan L
Published in Nature (London) (16.06.1994)
Published in Nature (London) (16.06.1994)
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