Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death
Kapralov, Alexandr A, Yang, Qin, Dar, Haider H, Tyurina, Yulia Y, Anthonymuthu, Tamil S, Kim, Rina, St Croix, Claudette M, Mikulska-Ruminska, Karolina, Liu, Bing, Shrivastava, Indira H, Tyurin, Vladimir A, Ting, Hsiu-Chi, Wu, Yijen L, Gao, Yuan, Shurin, Galina V, Artyukhova, Margarita A, Ponomareva, Liubov A, Timashev, Peter S, Domingues, Rosario M, Stoyanovsky, Detcho A, Greenberger, Joel S, Mallampalli, Rama K, Bahar, Ivet, Gabrilovich, Dmitry I, Bayır, Hülya, Kagan, Valerian E
Published in Nature chemical biology (01.03.2020)
Published in Nature chemical biology (01.03.2020)
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Autodeubiquitination Protects the Tumor Suppressor BAP1 from Cytoplasmic Sequestration Mediated by the Atypical Ubiquitin Ligase UBE2O
Mashtalir, Nazar, Daou, Salima, Barbour, Haithem, Sen, Nadine N., Gagnon, Jessica, Hammond-Martel, Ian, Dar, Haider H., Therrien, Marc, Affar, El Bachir
Published in Molecular cell (08.05.2014)
Published in Molecular cell (08.05.2014)
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PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells
Zhao, Jinming, Dar, Haider H., Deng, Yanhan, St. Croix, Claudette M., Li, Zhipeng, Minami, Yoshinori, Shrivastava, Indira H., Tyurina, Yulia Y., Etling, Emily, Rosenbaum, Joel C., Nagasaki, Tadao, Trudeau, John B., Watkins, Simon C., Bahar, Ivet, Bayır, Hülya, VanDemark, Andy P., Kagan, Valerian E., Wenzel, Sally E.
Published in Proceedings of the National Academy of Sciences - PNAS (23.06.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (23.06.2020)
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Journal Article
Empowerment of 15-Lipoxygenase Catalytic Competence in Selective Oxidation of Membrane ETE-PE to Ferroptotic Death Signals, HpETE-PE
Anthonymuthu, Tamil S, Kenny, Elizabeth M, Shrivastava, Indira, Tyurina, Yulia Y, Hier, Zachary E, Ting, Hsiu-Chi, Dar, Haider H, Tyurin, Vladimir A, Nesterova, Anastasia, Amoscato, Andrew A, Mikulska-Ruminska, Karolina, Rosenbaum, Joel C, Mao, Gaowei, Zhao, Jinming, Conrad, Marcus, Kellum, John A, Wenzel, Sally E, VanDemark, Andrew P, Bahar, Ivet, Kagan, Valerian E, Bayır, Hülya
Published in Journal of the American Chemical Society (26.12.2018)
Published in Journal of the American Chemical Society (26.12.2018)
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Journal Article
Resolving the paradox of ferroptotic cell death: Ferrostatin-1 binds to 15LOX/PEBP1 complex, suppresses generation of peroxidized ETE-PE, and protects against ferroptosis
Anthonymuthu, Tamil S., Tyurina, Yulia Y., Sun, Wan-Yang, Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Tyurin, Vladimir A., Cinemre, Fatma B., Dar, Haider H., VanDemark, Andrew P., Holman, Theodore R., Sadovsky, Yoel, Stockwell, Brent R., He, Rong-Rong, Bahar, Ivet, Bayır, Hülya, Kagan, Valerian E.
Published in Redox biology (01.01.2021)
Published in Redox biology (01.01.2021)
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Journal Article
A new thiol-independent mechanism of epithelial host defense against Pseudomonas aeruginosa: iNOS/NO• sabotage of theft-ferroptosis
Dar, Haider H., Anthonymuthu, Tamil S., Ponomareva, Liubov A., Souryavong, Austin B., Shurin, Galina V., Kapralov, Alexandr O., Tyurin, Vladimir A., Lee, Janet S., Mallampalli, Rama K., Wenzel, Sally E., Bayir, Hülya, Kagan, Valerian E.
Published in Redox biology (01.09.2021)
Published in Redox biology (01.09.2021)
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Journal Article
Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators
Dar, Haider H, Mikulska-Ruminska, Karolina, Tyurina, Yulia Y, Luci, Diane K, Yasgar, Adam, Samovich, Svetlana N, Kapralov, Alexander A, Souryavong, Austin B, Tyurin, Vladimir A, Amoscato, Andrew A, Epperly, Michael W, Shurin, Galina V, Standley, Melissa, Holman, Theodore R, St Croix, Claudette M, Watkins, Simon C, VanDemark, Andrew P, Rana, Sandeep, Zakharov, Alexey V, Simeonov, Anton, Marugan, Juan, Mallampalli, Rama K, Wenzel, Sally E, Greenberger, Joel S, Rai, Ganesha, Bayir, Hülya, Bahar, Ivet, Kagan, Valerian E
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (20.06.2023)
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Journal Article
Inactivation of RIP3 kinase sensitizes to 15LOX/PEBP1-mediated ferroptotic death
Lamade, Andrew M., Wu, Limin, Dar, Haider H., Mentrup, Heather L., Shrivastava, Indira H., Epperly, Michael W., St Croix, Claudette M., Tyurina, Yulia Y., Anthonymuthu, Tamil S., Yang, Qin, Kapralov, Aleksandr A., Huang, Zhentai, Mao, Gaowei, Amoscato, Andrew A., Hier, Zachary E., Artyukhova, Margarita A., Shurin, Galina, Rosenbaum, Joel C., Gough, Peter J., Bertin, John, VanDemark, Andrew P., Watkins, Simon C., Mollen, Kevin P., Bahar, Ivet, Greenberger, Joel S., Kagan, Valerian E., Whalen, Michael J., Bayır, Hülya
Published in Redox biology (01.04.2022)
Published in Redox biology (01.04.2022)
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Journal Article
Nanoemitters and innate immunity: the role of surfactants and bio-coronas in myeloperoxidase-catalyzed oxidation of pristine single-walled carbon nanotubes
Chiu, Cheuk Fai, Dar, Haider H, Kapralov, Alexandr A, Robinson, Renã A S, Kagan, Valerian E, Star, Alexander
Published in Nanoscale (14.05.2017)
Published in Nanoscale (14.05.2017)
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Journal Article
P. aeruginosa augments irradiation injury via 15-lipoxygenase-catalyzed generation of 15-HpETE-PE and induction of theft-ferroptosis
Dar, Haider H, Epperly, Michael W, Tyurin, Vladimir A, Amoscato, Andrew A, Anthonymuthu, Tamil S, Souryavong, Austin B, Kapralov, Alexander A, Shurin, Galina V, Samovich, Svetlana N, St Croix, Claudette M, Watkins, Simon C, Wenzel, Sally E, Mallampalli, Rama K, Greenberger, Joel S, Bayır, Hülya, Kagan, Valerian E, Tyurina, Yulia Y
Published in JCI insight (22.02.2022)
Published in JCI insight (22.02.2022)
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Journal Article
PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals
Wenzel, Sally E., Tyurina, Yulia Y., Zhao, Jinming, St. Croix, Claudette M., Dar, Haider H., Mao, Gaowei, Tyurin, Vladimir A., Anthonymuthu, Tamil S., Kapralov, Alexandr A., Amoscato, Andrew A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Kenny, Elizabeth M., Yang, Qin, Rosenbaum, Joel C., Sparvero, Louis J., Emlet, David R., Wen, Xiaoyan, Minami, Yoshinori, Qu, Feng, Watkins, Simon C., Holman, Theodore R., VanDemark, Andrew P., Kellum, John A., Bahar, Ivet, Bayır, Hülya, Kagan, Valerian E.
Published in Cell (19.10.2017)
Published in Cell (19.10.2017)
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Journal Article
Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal
Sun, Wan-Yang, Tyurin, Vladimir A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Anthonymuthu, Tamil S., Zhai, Yu-Jia, Pan, Ming-Hai, Gong, Hai-Biao, Lu, Dan-Hua, Sun, Jie, Duan, Wen-Jun, Korolev, Sergey, Abramov, Andrey Y., Angelova, Plamena R., Miller, Ian, Beharier, Ofer, Mao, Gao-Wei, Dar, Haider H., Kapralov, Alexandr A., Amoscato, Andrew A., Hastings, Teresa G., Greenamyre, Timothy J., Chu, Charleen T., Sadovsky, Yoel, Bahar, Ivet, Bayır, Hülya, Tyurina, Yulia Y., He, Rong-Rong, Kagan, Valerian E.
Published in Nature chemical biology (01.04.2021)
Published in Nature chemical biology (01.04.2021)
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Journal Article
PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
Yang, Xin, Wang, Zhe, Samovich, Svetlana N., Kapralov, Alexander A., Amoscato, Andrew A., Tyurin, Vladimir A., Dar, Haider H., Li, Zhiming, Duan, Shoufu, Kon, Ning, Chen, Delin, Tycko, Benjamin, Zhang, Zhiguo, Jiang, Xuejun, Bayir, Hülya, Stockwell, Brent R., Kagan, Valerian E., Gu, Wei
Published in Cell metabolism (02.04.2024)
Published in Cell metabolism (02.04.2024)
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Journal Article
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
Samovich, Svetlana N., Mikulska‐Ruminska, Karolina, Dar, Haider H., Tyurina, Yulia Y., Tyurin, Vladimir A., Souryavong, Austin B., Kapralov, Alexander A., Amoscato, Andrew A., Beharier, Ofer, Karumanchi, S. Ananth, St Croix, Claudette M., Yang, Xin, Holman, Theodore R., VanDemark, Andrew P., Sadovsky, Yoel, Mallampalli, Rama K., Wenzel, Sally E., Gu, Wei, Bunimovich, Yuri L., Bahar, Ivet, Kagan, Valerian E., Bayir, Hülya
Published in Angewandte Chemie International Edition (26.02.2024)
Published in Angewandte Chemie International Edition (26.02.2024)
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Journal Article
"Only a Life Lived for Others Is Worth Living": Redox Signaling by Oxygenated Phospholipids in Cell Fate Decisions
Tyurina, Yulia Y, Shrivastava, Indira, Tyurin, Vladimir A, Mao, Gaowei, Dar, Haider H, Watkins, Simon, Epperly, Michael, Bahar, Ivet, Shvedova, Anna A, Pitt, Bruce, Wenzel, Sally E, Mallampalli, Rama K, Sadovsky, Yoel, Gabrilovich, Dmitry, Greenberger, Joel S, Bayır, Hülya, Kagan, Valerian E
Published in Antioxidants & redox signaling (01.11.2018)
Published in Antioxidants & redox signaling (01.11.2018)
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Journal Article
Redox (phospho)lipidomics of signaling in inflammation and programmed cell death
Tyurina, Yulia Y., St. Croix, Claudette M., Watkins, Simon C., Watson, Alan M., Epperly, Michael W., Anthonymuthu, Tamil S., Kisin, Elena R., Vlasova, Irina I., Krysko, Olga, Krysko, Dmitri V., Kapralov, Alexandr A., Dar, Haider H., Tyurin, Vladimir A., Amoscato, Andrew A., Popova, Elena N., Bolevich, Sergey B., Timashev, Peter S., Kellum, John A., Wenzel, Sally E., Mallampalli, Rama K., Greenberger, Joel S., Bayir, Hulya, Shvedova, Anna A., Kagan, Valerian E.
Published in Journal of leukocyte biology (01.07.2019)
Published in Journal of leukocyte biology (01.07.2019)
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Journal Article
Pseudomonas aeruginosa utilizes host polyunsaturated phosphatidylethanolamines to trigger theft-ferroptosis in bronchial epithelium
Dar, Haider H, Tyurina, Yulia Y, Mikulska-Ruminska, Karolina, Shrivastava, Indira, Ting, Hsiu-Chi, Tyurin, Vladimir A, Krieger, James, St Croix, Claudette M, Watkins, Simon, Bayir, Erkan, Mao, Gaowei, Armbruster, Catherine R, Kapralov, Alexandr, Wang, Hong, Parsek, Matthew R, Anthonymuthu, Tamil S, Ogunsola, Abiola F, Flitter, Becca A, Freedman, Cody J, Gaston, Jordan R, Holman, Theodore R, Pilewski, Joseph M, Greenberger, Joel S, Mallampalli, Rama K, Doi, Yohei, Lee, Janet S, Bahar, Ivet, Bomberger, Jennifer M, Bayır, Hülya, Kagan, Valerian E
Published in The Journal of clinical investigation (01.10.2018)
Published in The Journal of clinical investigation (01.10.2018)
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Journal Article
Strikingly High Activity of 15‐Lipoxygenase Towards Di‐Polyunsaturated Arachidonoyl/Adrenoyl‐Phosphatidylethanolamines Generates Peroxidation Signals of Ferroptotic Cell Death
Samovich, Svetlana N., Mikulska‐Ruminska, Karolina, Dar, Haider H., Tyurina, Yulia Y., Tyurin, Vladimir A., Souryavong, Austin B., Kapralov, Alexander A., Amoscato, Andrew A., Beharier, Ofer, Karumanchi, S. Ananth, St Croix, Claudette M., Yang, Xin, Holman, Theodore R., VanDemark, Andrew P., Sadovsky, Yoel, Mallampalli, Rama K., Wenzel, Sally E., Gu, Wei, Bunimovich, Yuri L., Bahar, Ivet, Kagan, Valerian E., Bayir, Hülya
Published in Angewandte Chemie (26.02.2024)
Published in Angewandte Chemie (26.02.2024)
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Journal Article
Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome
Kagan, Valerian E, Tyurina, Yulia Y, Mikulska-Ruminska, Karolina, Damschroder, Deena, Vieira Neto, Eduardo, Lasorsa, Alessia, Kapralov, Alexander A, Tyurin, Vladimir A, Amoscato, Andrew A, Samovich, Svetlana N, Souryavong, Austin B, Dar, Haider H, Ramim, Abu, Liang, Zhuqing, Lazcano, Pablo, Ji, Jiajia, Schmidtke, Michael W, Kiselyov, Kirill, Korkmaz, Aybike, Vladimirov, Georgy K, Artyukhova, Margarita A, Rampratap, Pushpa, Cole, Laura K, Niyatie, Ammanamanchi, Baker, Emma-Kate, Peterson, Jim, Hatch, Grant M, Atkinson, Jeffrey, Vockley, Jerry, Kühn, Bernhard, Wessells, Robert, van der Wel, Patrick C A, Bahar, Ivet, Bayir, Hülya, Greenberg, Miriam L
Published in Nature metabolism (01.12.2023)
Published in Nature metabolism (01.12.2023)
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Journal Article
Nano Emitters and Innate Immunity: The Role of Surfactants and Bio-Coronas in Myeloperoxidase-catalyzed Oxidation of Pristine Single-Walled Carbon Nanotubes
Chiu, Cheuk Fai, Dar, Haider H., Kapralov, Alexandr A., Robinson, Renã A. S., Kagan, Valerian E., Star, Alexander
Published in Nanoscale (11.05.2017)
Published in Nanoscale (11.05.2017)
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