Synthesis of Highly Functionalized 4-Iodo-7-azaindazoles via Condensation/Diels-Alder/Retro-Diels-Alder Cyclization of Iodoalkynones and 2-Hydrazineylpyrimidines
Swift, Elizabeth C., Sales, Zachary S., Wu, Dongpei, Matviitsuk, Anastassia, Pippel, Daniel J., Lebold, Terry P.
Published in Organic letters (08.12.2023)
Published in Organic letters (08.12.2023)
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Journal Article
Blue Light-Mediated, Photocatalyst-Free Decarboxylative Alkylation of Heteroaryl Sulfinimines
Zhou, Zhe, Sales, Zachary S., Pippel, Daniel J., Qian, Michael, Martin, Connor L.
Published in Journal of organic chemistry (04.11.2022)
Published in Journal of organic chemistry (04.11.2022)
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Journal Article
Design, Synthesis, and Preclinical Evaluation of 3‑Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5‑b]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders
Chrovian, Christa C, Soyode-Johnson, Akinola, Stenne, Brice, Pippel, Daniel J, Schoellerman, Jeffrey, Lord, Brian, Needham, Alexandra S, Xia, Chungfang, Coe, Kevin J, Sepassi, Kia, Schoetens, Freddy, Scott, Brian, Nguyen, Leslie, Jiang, Xiaohui, Koudriakova, Tatiana, Balana, Bartosz, Letavic, Michael A
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Novel Octahydropyrrolo[3,4‑c]pyrroles Are Selective Orexin‑2 Antagonists: SAR Leading to a Clinical Candidate
Letavic, Michael A., Bonaventure, Pascal, Carruthers, Nicholas I., Dugovic, Christine, Koudriakova, Tatiana, Lord, Brian, Lovenberg, Timothy W., Ly, Kiev S., Mani, Neelakandha S., Nepomuceno, Diane, Pippel, Daniel J., Rizzolio, Michele, Shelton, Jonathan E., Shah, Chandra R., Shireman, Brock T., Young, Lana K., Yun, Sujin
Published in Journal of medicinal chemistry (23.07.2015)
Published in Journal of medicinal chemistry (23.07.2015)
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Journal Article
Temperature- and Electrophile-Dependent Stereocontrol: A Structural and Mechanistic Investigation of (−)-Sparteine-Mediated Asymmetric Lithiation−Substitution Sequences of N-Boc-N-(p-Methoxyphenyl)cinnamylamine
Weisenburger, Gerald A, Faibish, Neil C, Pippel, Daniel J, Beak, Peter
Published in Journal of the American Chemical Society (20.10.1999)
Published in Journal of the American Chemical Society (20.10.1999)
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Journal Article
Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793
Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T
Published in ACS medicinal chemistry letters (08.10.2020)
Published in ACS medicinal chemistry letters (08.10.2020)
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Journal Article
Lead Optimization of 5‑Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ‑8
Ravula, Suchitra, Savall, Brad M, Wu, Nyantsz, Lord, Brian, Coe, Kevin, Wang, Kai, Seierstad, Mark, Swanson, Devin M, Ziff, Jeannie, Nguyen, Minh, Leung, Perry, Rynberg, Ray, La, David, Pippel, Daniel J, Koudriakova, Tatiana, Lovenberg, Timothy W, Carruthers, Nicholas I, Maher, Michael P, Ameriks, Michael K
Published in ACS medicinal chemistry letters (09.08.2018)
Published in ACS medicinal chemistry letters (09.08.2018)
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Journal Article
Novel pyrazole derivatives as potent inhibitors of type II topoisomerases. Part 1: Synthesis and preliminary SAR analysis
Gomez, Laurent, Hack, Michael D., Wu, Jiejun, Wiener, John J.M., Venkatesan, Hari, Santillán, Alejandro, Pippel, Daniel J., Mani, Neelakandha, Morrow, Brian J., Motley, S. Timothy, Shaw, Karen Joy, Wolin, Ronald, Grice, Cheryl A., Jones, Todd K.
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
Published in Bioorganic & medicinal chemistry letters (15.05.2007)
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Journal Article
Solid-State Structural Investigation of an Organolithium (−)-Sparteine Complex: η3-N-Boc-N-(p-methoxyphenyl)-3-phenylallyllithium⋅(−)-Sparteine
Pippel, Daniel J., Weisenburger, Gerald A., Wilson, Scott R., Beak, Peter
Published in Angewandte Chemie International Edition (02.10.1998)
Published in Angewandte Chemie International Edition (02.10.1998)
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Journal Article
Complex-Induced Proximity Effects: Stereoselective Carbon−Carbon Bond Formation in Chiral Auxiliary Mediated β-Lithiation−Substitution Sequences of β-Substituted Secondary Carboxamides
Pippel, Daniel J, Curtis, Michael D, Du, Hua, Beak, Peter
Published in Journal of organic chemistry (09.01.1998)
Published in Journal of organic chemistry (09.01.1998)
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Journal Article
Mechanism of Electrophilic Chlorination: Experimental Determination of a Geometrical Requirement for Chlorine Transfer by the Endocyclic Restriction Test
Lee, Suk Joong, Terrazas, Michael S, Pippel, Daniel J, Beak, Peter
Published in Journal of the American Chemical Society (18.06.2003)
Published in Journal of the American Chemical Society (18.06.2003)
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Journal Article
On the coupling reaction of lithium azaenolates of chiral oxazolines with carbonyl compounds
Florio, Saverio, Capriati, Vito, Luisi, Renzo, Abbotto, Alessandro, Pippel, Daniel J
Published in Tetrahedron (30.07.2001)
Published in Tetrahedron (30.07.2001)
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Journal Article
Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102
Yang, Xiaogen, Li, Zhiwen, Xu, Wenwen, Zhu, Guanming, Feng, Xiantong, Zhang, Jun, Zhao, Hongbin, Chen, Yuyin, Kong, Jianshe, Mai, Wanping, Li, Lian-Sheng, Pippel, Daniel J., Ren, Pingda, Deng, Xiaohu
Published in Organic process research & development (20.01.2023)
Published in Organic process research & development (20.01.2023)
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Journal Article
Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRAS G12C Inhibitor ARS-2102
Yang, Xiaogen, Li, Zhiwen, Xu, Wenwen, Zhu, Guanming, Feng, Xiantong, Zhang, Jun, Zhao, Hongbin, Chen, Yuyin, Kong, Jianshe, Mai, Wanping, Li, Lian-Sheng, Pippel, Daniel J., Ren, Pingda, Deng, Xiaohu
Published in Organic process research & development (20.01.2023)
Published in Organic process research & development (20.01.2023)
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Journal Article
Synthesis of a Histamine H-3 Receptor Antagonist-Manipulation of Hydroxyproline Stereochemistry, Desymmetrization of Homopiperazine, and Nonextractive Sodium Triacetoxyborohydride Reaction Workup
Pippel, Daniel J., Young, Lana K., Letavic, Michael A., Ly, Kiev S., Naderi, Bita, Soyode-Johnson, Aki, Stocking, Emily M., Carruthers, Nicholas I., Mani, Neelakandha S.
Published in Journal of organic chemistry (02.07.2010)
Published in Journal of organic chemistry (02.07.2010)
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Journal Article
First, Second, and Third Generation Scalable Syntheses of Two Potent H 3 Antagonists
Pippel, Daniel J., Mills, John E., Pandit, Chennagiri R., Young, Lana K., Zhong, Hua M., Villani, Frank J., Mani, Neelakandha S.
Published in Organic process research & development (20.05.2011)
Published in Organic process research & development (20.05.2011)
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Journal Article
Synthesis of a Histamine H3 Receptor AntagonistManipulation of Hydroxyproline Stereochemistry, Desymmetrization of Homopiperazine, and Nonextractive Sodium Triacetoxyborohydride Reaction Workup
Pippel, Daniel J, Young, Lana K, Letavic, Michael A, Ly, Kiev S, Naderi, Bita, Soyode-Johnson, Aki, Stocking, Emily M, Carruthers, Nicholas I, Mani, Neelakandha S
Published in Journal of organic chemistry (02.07.2010)
Published in Journal of organic chemistry (02.07.2010)
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