Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans: Part C: Use of QSAR and an expert system for the estimation of the mechanism of action of drug-induced hepatobiliary and urinary tract toxicities
Matthews, Edwin J., Kruhlak, Naomi L., Daniel Benz, R., Sabaté, David Aragonés, Marchant, Carol A., Contrera, Joseph F.
Published in Regulatory toxicology and pharmacology (01.06.2009)
Published in Regulatory toxicology and pharmacology (01.06.2009)
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Journal Article
Combined Use of MC4PC, MDL-QSAR, BioEpisteme, Leadscope PDM, and Derek for Windows Software to Achieve High-Performance, High-Confidence, Mode of Action-Based Predictions of Chemical Carcinogenesis in Rodents
Matthews, Edwin J., Kruhlak, Naomi L., Benz, R. Daniel, Contrera, Joseph F., Marchant, Carol A., Yang, Chihae
Published in Toxicology mechanisms and methods (01.01.2008)
Published in Toxicology mechanisms and methods (01.01.2008)
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Journal Article
A comprehensive model for reproductive and developmental toxicity hazard identification: II. Construction of QSAR models to predict activities of untested chemicals
Matthews, Edwin J., Kruhlak, Naomi L., Daniel Benz, R., Ivanov, Julian, Klopman, Gilles, Contrera, Joseph F.
Published in Regulatory toxicology and pharmacology (01.03.2007)
Published in Regulatory toxicology and pharmacology (01.03.2007)
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Journal Article
Testing computational toxicology models with phytochemicals
Valerio, Luis G. Jr, Arvidson, Kirk B, Busta, Emily, Minnier, Barbara L, Kruhlak, Naomi L, Benz, R. Daniel
Published in Molecular nutrition & food research (01.02.2010)
Published in Molecular nutrition & food research (01.02.2010)
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Journal Article
A comprehensive model for reproductive and developmental toxicity hazard identification: I. Development of a weight of evidence QSAR database
Matthews, Edwin J., Kruhlak, Naomi L., Daniel Benz, R., Contrera, Joseph F.
Published in Regulatory toxicology and pharmacology (01.03.2007)
Published in Regulatory toxicology and pharmacology (01.03.2007)
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Journal Article
Next generation testing strategy for assessment of genomic damage: A conceptual framework and considerations
Dearfield, Kerry L., Gollapudi, B. Bhaskar, Bemis, Jeffrey C., Benz, R. Daniel, Douglas, George R., Elespuru, Rosalie K., Johnson, George E., Kirkland, David J., LeBaron, Matthew J., Li, Albert P., Marchetti, Francesco, Pottenger, Lynn H., Rorije, Emiel, Tanir, Jennifer Y., Thybaud, Veronique, van Benthem, Jan, Yauk, Carole L., Zeiger, Errol, Luijten, Mirjam
Published in Environmental and molecular mutagenesis (01.06.2017)
Published in Environmental and molecular mutagenesis (01.06.2017)
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Journal Article
Identification of structure-activity relationships for adverse effects of pharmaceuticals in humans: Part B. Use of (Q)SAR systems for early detection of drug-induced hepatobiliary and urinary tract toxicities
Matthews, Edwin J., Ursem, Carling J., Kruhlak, Naomi L., Benz, R. Daniel, Sabaté, David Aragonés, Yang, Chihae, Klopman, Gilles, Contrera, Joseph F.
Published in Regulatory toxicology and pharmacology (01.06.2009)
Published in Regulatory toxicology and pharmacology (01.06.2009)
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Journal Article
New and emerging technologies for genetic toxicity testing
Lynch, Anthony M, Sasaki, Jennifer C, Elespuru, Rosalie, Jacobson-Kram, David, Thybaud, Véronique, De Boeck, Marlies, Aardema, Marilyn J, Aubrecht, Jiri, Benz, R. Daniel, Dertinger, Stephen D, Douglas, George R, White, Paul A, Escobar, Patricia A, Fornace, Albert Jr, Honma, Masamitsu, Naven, Russell T, Rusling, James F, Schiestl, Robert H, Walmsley, Richard M, Yamamura, Eiji, van Benthem, Jan, Kim, James H
Published in Environmental and molecular mutagenesis (01.04.2011)
Published in Environmental and molecular mutagenesis (01.04.2011)
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Journal Article
Comparison of MC4PC and MDL-QSAR rodent carcinogenicity predictions and the enhancement of predictive performance by combining QSAR models
Contrera, Joseph F., Kruhlak, Naomi L., Matthews, Edwin J., Benz, R. Daniel
Published in Regulatory toxicology and pharmacology (01.12.2007)
Published in Regulatory toxicology and pharmacology (01.12.2007)
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Journal Article
Identification of structure–activity relationships for adverse effects of pharmaceuticals in humans. Part A: Use of FDA post-market reports to create a database of hepatobiliary and urinary tract toxicities
Ursem, Carling J., Kruhlak, Naomi L., Contrera, Joseph F., MacLaughlin, Philip M., Benz, R. Daniel, Matthews, Edwin J.
Published in Regulatory toxicology and pharmacology (01.06.2009)
Published in Regulatory toxicology and pharmacology (01.06.2009)
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Journal Article
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: I. Identification of carcinogens using surrogate endpoints
Matthews, Edwin J., Kruhlak, Naomi L., Cimino, Michael C., Benz, R. Daniel, Contrera, Joseph F.
Published in Regulatory toxicology and pharmacology (01.03.2006)
Published in Regulatory toxicology and pharmacology (01.03.2006)
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Journal Article
An analysis of genetic toxicity, reproductive and developmental toxicity, and carcinogenicity data: II. Identification of genotoxicants, reprotoxicants, and carcinogens using in silico methods
Matthews, Edwin J., Kruhlak, Naomi L., Cimino, Michael C., Benz, R. Daniel, Contrera, Joseph F.
Published in Regulatory toxicology and pharmacology (01.03.2006)
Published in Regulatory toxicology and pharmacology (01.03.2006)
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Journal Article
Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
Contrera, Joseph F., Matthews, Edwin J., Kruhlak, Naomi L., Benz, R. Daniel
Published in Regulatory toxicology and pharmacology (01.12.2004)
Published in Regulatory toxicology and pharmacology (01.12.2004)
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Journal Article
Assessment of the health effects of chemicals in humans: I. QSAR estimation of the maximum recommended therapeutic dose (MRTD) and no effect level (NOEL) of organic chemicals based on clinical trial data
Matthews, Edwin J, Kruhlak, Naomi L, Benz, R Daniel, Contrera, Joseph F
Published in Current drug discovery technologies (01.01.2004)
Published in Current drug discovery technologies (01.01.2004)
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Journal Article
In Silico Screening of Chemicals for Genetic Toxicity Using MDL-QSAR, Nonparametric Discriminant Analysis, E-State, Connectivity, and Molecular Property Descriptors
Contrera, Joseph F., Matthews, Edwin J., Kruhlak, Naomi L., Benz, R. Daniel
Published in Toxicology mechanisms and methods (01.01.2008)
Published in Toxicology mechanisms and methods (01.01.2008)
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Journal Article