Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew
Published in Nature communications (23.10.2020)
Published in Nature communications (23.10.2020)
Get full text
Journal Article
The P522R protective variant of PLCG2 promotes the expression of antigen presentation genes by human microglia in an Alzheimer's disease mouse model
Claes, Christel, England, Whitney E., Danhash, Emma P., Kiani Shabestari, Sepideh, Jairaman, Amit, Chadarevian, Jean Paul, Hasselmann, Jonathan, Tsai, Andy P., Coburn, Morgan A., Sanchez, Jessica, Lim, Tau En, Hidalgo, Jorge L. S., Tu, Christina, Cahalan, Michael D., Lamb, Bruce T., Landreth, Gary E., Spitale, Robert C., Blurton‐Jones, Mathew, Davtyan, Hayk
Published in Alzheimer's & dementia (01.10.2022)
Published in Alzheimer's & dementia (01.10.2022)
Get full text
Journal Article
Author Correction: Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer’s disease
McQuade, Amanda, Kang, You Jung, Hasselmann, Jonathan, Jairaman, Amit, Sotelo, Alexandra, Coburn, Morgan, Shabestari, Sepideh Kiani, Chadarevian, Jean Paul, Fote, Gianna, Tu, Christina H., Danhash, Emma, Silva, Jorge, Martinez, Eric, Cotman, Carl, Prieto, G. Aleph, Thompson, Leslie M., Steffan, Joan S., Smith, Ian, Davtyan, Hayk, Cahalan, Michael, Cho, Hansang, Blurton-Jones, Mathew
Published in Nature communications (02.03.2023)
Published in Nature communications (02.03.2023)
Get full text
Journal Article
Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice
Davtyan, Hayk, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Antonyan, Tatevik, Coburn, Morgan A, Zagorski, Karen, Chailyan, Gor, Petrushina, Irina, Svystun, Olga, Danhash, Emma, Petrovsky, Nikolai, Cribbs, David H, Agadjanyan, Michael G, Blurton-Jones, Mathew, Ghochikyan, Anahit
Published in Alzheimer's research & therapy (17.12.2019)
Published in Alzheimer's research & therapy (17.12.2019)
Get full text
Journal Article
Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease
Claes, Christel, Danhash, Emma Pascal, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, England, Whitney E, Lim, Tau En, Hidalgo, Jorge Luis Silva, Spitale, Robert C, Davtyan, Hayk, Blurton-Jones, Mathew
Published in Molecular neurodegeneration (23.07.2021)
Published in Molecular neurodegeneration (23.07.2021)
Get full text
Journal Article
Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice
Kiani Shabestari, Sepideh, Morabito, Samuel, Danhash, Emma Pascal, McQuade, Amanda, Sanchez, Jessica Ramirez, Miyoshi, Emily, Chadarevian, Jean Paul, Claes, Christel, Coburn, Morgan Alexandra, Hasselmann, Jonathan, Hidalgo, Jorge, Tran, Kayla Nhi, Martini, Alessandra C., Chang Rothermich, Winston, Pascual, Jesse, Head, Elizabeth, Hume, David A., Pridans, Clare, Davtyan, Hayk, Swarup, Vivek, Blurton-Jones, Mathew
Published in Cell reports (Cambridge) (14.06.2022)
Published in Cell reports (Cambridge) (14.06.2022)
Get full text
Journal Article
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
Martini, Alessandra Cadete, Gomez-Arboledas, Angela, Forner, Stefania, Rodriguez-Ortiz, Carlos J., McQuade, Amanda, Danhash, Emma, Phan, Jimmy, Javonillo, Dominic, Ha, Jordan-Vu, Tram, Melanie, Trujillo-Estrada, Laura, da Cunha, Celia, Ager, Rahasson R., Davila, Jose C., Kitazawa, Masashi, Blurton-Jones, Mathew, Gutierrez, Antonia, Baglietto-Vargas, David, Medeiros, Rodrigo, LaFerla, Frank M.
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2019)
Get full text
Journal Article
The first MultiTEP‐based conjugated vaccine targeting pyroglutamated pE3‐Aβ is immunogenic and effective in a 5xFAD animal model
Zagorski, Karen, King, Olga, Hovakimyan, Armine, Antonyan, Tatevik, Petrushina, Irina, Chadarevian, Jean Paul, Danhash, Emma, Cribbs, David H., Davtyan, Hayk, Blurton‐Jones, Mathew, Agadjanyan, Michael G, Ghochikyan, Anahit
Published in Alzheimer's & dementia (01.12.2021)
Published in Alzheimer's & dementia (01.12.2021)
Get full text
Journal Article
The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C
Pluvinage, John V, Sun, Jerry, Claes, Christel, Flynn, Ryan A, Haney, Michael S, Iram, Tal, Meng, Xiangling, Lindemann, Rachel, Riley, Nicholas M, Danhash, Emma, Chadarevian, Jean Paul, Tapp, Emma, Gate, David, Kondapavulur, Sravani, Cobos, Inma, Chetty, Sundari, Pașca, Anca M, Pașca, Sergiu P, Berry-Kravis, Elizabeth, Bertozzi, Carolyn R, Blurton-Jones, Mathew, Wyss-Coray, Tony
Published in Science translational medicine (01.12.2021)
Published in Science translational medicine (01.12.2021)
Get more information
Journal Article
Phospholipase D3 drives microglial response to amyloid pathology in Alzheimer’s disease
Rosene, Matthew J, Danhash, Emma, You, Shih‐Feng, Iyer, Abhirami Kannan, Hsu, Simon, de Sa Lopes, Mariana Acquarone, Brase, Logan, Verbeck, Anthony, Martinez, Rita, Wallace, Clare E, Li, Zeran, Yan, Ping, Drager, Nina, Sattler, Sydney M, Mahan, Thomas E, Macauley, Shannon L, Holtzman, David M., Benitez, Bruno A., Kampmann, Martin, Cruchaga, Carlos, Harari, Oscar, Cirrito, John R, Lee, Jin‐Moo, Goate, Alison, Karch, Celeste M.
Published in Alzheimer's & dementia (01.12.2023)
Published in Alzheimer's & dementia (01.12.2023)
Get full text
Journal Article
Examining the effects of the microglial PLCG2 P522R mutation by transplantation of human stem cell‐derived microglia in chimeric AD mice
Claes, Christel, Danhash, Emma, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, Lim, Tau En, Tu, Christina, Silva, Jorge, Coburn, Morgan A., Jairaman, Amit, Cahalan, Michael, Blurton‐Jones, Mathew, Davtyan, Hayk
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
Get full text
Journal Article
Examining the effects of the microglial PLCG2 P522R mutation by transplantation of human stem cell‐derived microglia in chimeric AD mice: Molecular and cell biology/stem cells, iPS cells
Claes, Christel, Danhash, Emma, Hasselmann, Jonathan, Chadarevian, Jean Paul, Shabestari, Sepideh Kiani, Lim, Tau En, Tu, Christina, Silva, Jorge, Coburn, Morgan A., Jairaman, Amit, Cahalan, Michael, Blurton‐Jones, Mathew, Davtyan, Hayk
Published in Alzheimer's & dementia (01.12.2020)
Published in Alzheimer's & dementia (01.12.2020)
Get full text
Journal Article
Testing a MultiTEP-based combination vaccine to reduce A[beta] and tau pathology in Tau22/5xFAD bigenic mice
Davtyan, Hayk, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Antonyan, Tatevik, Coburn, Morgan A, Zagorski, Karen, Chailyan, Gor, Petrushina, Irina, Svystun, Olga, Danhash, Emma, Petrovsky, Nikolai, Cribbs, David H, Agadjanyan, Michael G, Blurton-Jones, Mathew, Ghochikyan, Anahit
Published in Alzheimer's research & therapy (17.12.2019)
Published in Alzheimer's research & therapy (17.12.2019)
Get full text
Journal Article
Cell autonomous microglia defects in a stem cell model of frontotemporal dementia
Iyer, Abhirami K, Vermunt, Lisa, Mirfakhar, Farzaneh S, Minaya, Miguel, Acquarone, Mariana, Koppisetti, Rama Krishna, Renganathan, Arun, You, Shih-Feng, Danhash, Emma P, Verbeck, Anthony, Galasso, Grant, Lee, Scott M, Marsh, Jacob, Nana, Alissa L, Spina, Salvatore, Seeley, William W, Grinberg, Lea T, Temple, Sally, Teunissen, Charlotte E, Sato, Chihiro, Karch, Celeste M
Published in medRxiv : the preprint server for health sciences (16.05.2024)
Get more information
Published in medRxiv : the preprint server for health sciences (16.05.2024)
Journal Article