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Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2010)
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Target identification and mechanism of action in chemical biology and drug discovery
Schenone, Monica, Dančík, Vlado, Wagner, Bridget K, Clemons, Paul A
Published in Nature chemical biology (01.04.2013)
Published in Nature chemical biology (01.04.2013)
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A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis
Zou, Yilong, Palte, Michael J, Deik, Amy A, Li, Haoxin, Eaton, John K, Wang, Wenyu, Tseng, Yuen-Yi, Deasy, Rebecca, Kost-Alimova, Maria, Dančík, Vlado, Leshchiner, Elizaveta S, Viswanathan, Vasanthi S, Signoretti, Sabina, Choueiri, Toni K, Boehm, Jesse S, Wagner, Bridget K, Doench, John G, Clish, Clary B, Clemons, Paul A, Schreiber, Stuart L
Published in Nature communications (08.04.2019)
Published in Nature communications (08.04.2019)
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Plasticity of ether lipids promotes ferroptosis susceptibility and evasion
Zou, Yilong, Henry, Whitney S, Ricq, Emily L, Graham, Emily T, Phadnis, Vaishnavi V, Maretich, Pema, Paradkar, Sateja, Boehnke, Natalie, Deik, Amy A, Reinhardt, Ferenc, Eaton, John K, Ferguson, Bryan, Wang, Wenyu, Fairman, Joshua, Keys, Heather R, Dančík, Vlado, Clish, Clary B, Clemons, Paul A, Hammond, Paula T, Boyer, Laurie A, Weinberg, Robert A, Schreiber, Stuart L
Published in Nature (London) (24.09.2020)
Published in Nature (London) (24.09.2020)
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Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells
Sundberg, Thomas B., Choi, Hwan Geun, Song, Joo-Hye, Russell, Caitlin N., Hussain, Mahmud M., Graham, Daniel B., Khor, Bernard, Gagnon, John, O'Connell, Daniel J., Narayan, Kavitha, Dančik, Vlado, Perez, Jose R., Reinecker, Hans-Christian, Gray, Nathanael S., Schreiber, Stuart L., Xavier, Ramnik J., Shamji, Alykhan F.
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2014)
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A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9
Maji, Basudeb, Gangopadhyay, Soumyashree A., Lee, Miseon, Shi, Mengchao, Wu, Peng, Heler, Robert, Mok, Beverly, Lim, Donghyun, Siriwardena, Sachini U., Paul, Bishwajit, Dančík, Vlado, Vetere, Amedeo, Mesleh, Michael F., Marraffini, Luciano A., Liu, David R., Clemons, Paul A., Wagner, Bridget K., Choudhary, Amit
Published in Cell (02.05.2019)
Published in Cell (02.05.2019)
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Correlating chemical sensitivity and basal gene expression reveals mechanism of action
Rees, Matthew G, Seashore-Ludlow, Brinton, Cheah, Jaime H, Adams, Drew J, Price, Edmund V, Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E, Jones, Victor L, Bodycombe, Nicole E, Soule, Christian K, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A, Clish, Clary B, Bittker, Joshua A, Palmer, Michelle, Wagner, Bridget K, Clemons, Paul A, Shamji, Alykhan F, Schreiber, Stuart L
Published in Nature chemical biology (01.02.2016)
Published in Nature chemical biology (01.02.2016)
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Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset
Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L
Published in Cancer discovery (01.11.2015)
Published in Cancer discovery (01.11.2015)
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High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases
Bessen, Jeffrey L, Afeyan, Lena K, Dančík, Vlado, Koblan, Luke W, Thompson, David B, Leichner, Chas, Clemons, Paul A, Liu, David R
Published in Nature communications (26.04.2019)
Published in Nature communications (26.04.2019)
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A dataset of images and morphological profiles of 30 000 small-molecule treatments using the Cell Painting assay
Bray, Mark-Anthony, Gustafsdottir, Sigrun M, Rohban, Mohammad H, Singh, Shantanu, Ljosa, Vebjorn, Sokolnicki, Katherine L, Bittker, Joshua A, Bodycombe, Nicole E, Dančík, Vlado, Hasaka, Thomas P, Hon, Cindy S, Kemp, Melissa M, Li, Kejie, Walpita, Deepika, Wawer, Mathias J, Golub, Todd R, Schreiber, Stuart L, Clemons, Paul A, Shamji, Alykhan F, Carpenter, Anne E
Published in Gigascience (01.12.2017)
Published in Gigascience (01.12.2017)
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High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function
Burns, Sean M., Vetere, Amedeo, Walpita, Deepika, Dančík, Vlado, Khodier, Carol, Perez, Jose, Clemons, Paul A., Wagner, Bridget K., Altshuler, David
Published in Cell metabolism (06.01.2015)
Published in Cell metabolism (06.01.2015)
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Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics
Kuo, Szu-Yu, Castoreno, Adam B., Aldrich, Leslie N., Lassen, Kara G., Goel, Gautam, Dančík, Vlado, Kuballa, Petric, Latorre, Isabel, Conway, Kara L., Sarkar, Sovan, Maetzel, Dorothea, Jaenisch, Rudolf, Clemons, Paul A., Schreiber, Stuart L., Shamji, Alykhan F., Xavier, Ramnik J.
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2015)
Published in Proceedings of the National Academy of Sciences - PNAS (04.08.2015)
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Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease
Leshchiner, Elizaveta S., Rush, Jason S., Durney, Michael A., Cao, Zhifang, Dančík, Vlado, Chittick, Benjamin, Wu, Huixian, Petrone, Adam, Bittker, Joshua A., Phillips, Andrew, Perez, Jose R., Shamji, Alykhan F., Kaushik, Virendar K., Daly, Mark J., Graham, Daniel B., Schreiber, Stuart L., Xavier, Ramnik J.
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (24.10.2017)
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Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
Dirice, Ercument, Walpita, Deepika, Vetere, Amedeo, Meier, Bennett C, Kahraman, Sevim, Hu, Jiang, Dančík, Vlado, Burns, Sean M, Gilbert, Tamara J, Olson, David E, Clemons, Paul A, Kulkarni, Rohit N, Wagner, Bridget K
Published in Diabetes (New York, N.Y.) (01.06.2016)
Published in Diabetes (New York, N.Y.) (01.06.2016)
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Knowledge Beacons: Web services for data harvesting of distributed biomedical knowledge
Hannestad, Lance M, Dančík, Vlado, Godden, Meera, Suen, Imelda W, Huellas-Bruskiewicz, Kenneth C, Good, Benjamin M, Mungall, Christopher J, Bruskiewich, Richard M
Published in PloS one (23.03.2021)
Published in PloS one (23.03.2021)
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Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling
Wawer, Mathias J., Li, Kejie, Gustafsdottir, Sigrun M., Ljos, Vebjorn, Bodycombe, Nicole E., Marton, Melissa A., Sokolnicki, Katherine L., Bray, Mark-Anthony, Kemp, Melissa M., Winchester, Ellen, Taylor, Bradley, Grant, George B., Hon, C. Suk-Yee, Duvall, Jeremy R., Wilson, J. Anthony, Bittker, Joshua A., Dančík, Vlado, Narayan, Rajiv, Subramanian, Aravind, Winckler, Wendy, Golub, Todd R., Carpenter, Anne E., Shamji, Alykhan F., Schreiber, Stuart L., Clemons, Paul A.
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (29.07.2014)
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Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections
Clemons, Paul A, Wilson, J. Anthony, DanÄÃk, Vlado, Muller, Sandrine, Carrinski, Hyman A, Wagner, Bridget K, Koehler, Angela N, Schreiber, Stuart L
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (26.04.2011)
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Predicting compound activity from phenotypic profiles and chemical structures
Moshkov, Nikita, Becker, Tim, Yang, Kevin, Horvath, Peter, Dancik, Vlado, Wagner, Bridget K, Clemons, Paul A, Singh, Shantanu, Carpenter, Anne E, Caicedo, Juan C
Published in Nature communications (08.04.2023)
Published in Nature communications (08.04.2023)
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DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets
Hanaford, Allison R, Archer, Tenley C, Price, Antoinette, Kahlert, Ulf D, Maciaczyk, Jarek, Nikkhah, Guido, Kim, Jong Wook, Ehrenberger, Tobias, Clemons, Paul A, Dančík, Vlado, Seashore-Ludlow, Brinton, Viswanathan, Vasanthi, Stewart, Michelle L, Rees, Matthew G, Shamji, Alykhan, Schreiber, Stuart, Fraenkel, Ernest, Pomeroy, Scott L, Mesirov, Jill P, Tamayo, Pablo, Eberhart, Charles G, Raabe, Eric H
Published in Clinical cancer research (01.08.2016)
Published in Clinical cancer research (01.08.2016)
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