A first-in-man phase 1 study of the DNA-dependent protein kinase inhibitor peposertib (formerly M3814) in patients with advanced solid tumours
van Bussel, Mark T. J., Awada, Ahmad, de Jonge, Maja J. A., Mau-Sørensen, Morten, Nielsen, Dorte, Schöffski, Patrick, Verheul, Henk M. W., Sarholz, Barbara, Berghoff, Karin, El Bawab, Samer, Kuipers, Mirjam, Damstrup, Lars, Diaz-Padilla, Ivan, Schellens, Jan H. M.
Published in British journal of cancer (16.02.2021)
Published in British journal of cancer (16.02.2021)
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Journal Article
Epidermal Growth Factor Receptor Activation Induces Nuclear Targeting of Cyclooxygenase-2, Basolateral Release of Prostaglandins, and Mitogenesis in Polarizing Colon Cancer Cells
Coffey, Robert J., Hawkey, Chris J., Damstrup, Lars, Graves-Deal, Ramona, Daniel, Vincent C., Dempsey, Peter J., Chinery, Rebecca, Kirkland, Susan C., DuBois, Raymond N., Jetton, Thomas L., Morrow, Jason D.
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.1997)
Published in Proceedings of the National Academy of Sciences - PNAS (21.01.1997)
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Journal Article
Analysis of the epidermal growth factor receptor specific transcriptome: Effect of receptor expression level and an activating mutation
Pedersen, Mikkel W., Pedersen, Nina, Damstrup, Lars, Villingshøj, Mette, Sønder, Søren U., Rieneck, Klaus, Bovin, Lone F., Spang-Thomsen, Mogens, Poulsen, Hans S.
Published in Journal of cellular biochemistry (01.10.2005)
Published in Journal of cellular biochemistry (01.10.2005)
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Journal Article
A phase Ib dose-escalation and expansion study of the oral MEK inhibitor pimasertib and PI3K/MTOR inhibitor voxtalisib in patients with advanced solid tumours
Schram, Alison M., Gandhi, Leena, Mita, Monica M., Damstrup, Lars, Campana, Frank, Hidalgo, Manuel, Grande, Enrique, Hyman, David M., Heist, Rebecca S.
Published in British journal of cancer (11.12.2018)
Published in British journal of cancer (11.12.2018)
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Clinical development of new drug–radiotherapy combinations
Sharma, Ricky A., Plummer, Ruth, Stock, Julie K., Greenhalgh, Tessa A., Ataman, Ozlem, Kelly, Stephen, Clay, Robert, Adams, Richard A., Baird, Richard D., Billingham, Lucinda, Brown, Sarah R., Buckland, Sean, Bulbeck, Helen, Chalmers, Anthony J., Clack, Glen, Cranston, Aaron N., Damstrup, Lars, Ferraldeschi, Roberta, Forster, Martin D., Golec, Julian, Hagan, Russell M., Hall, Emma, Hanauske, Axel-R., Harrington, Kevin J., Haswell, Tom, Hawkins, Maria A., Illidge, Tim, Jones, Hazel, Kennedy, Andrew S., McDonald, Fiona, Melcher, Thorsten, O'Connor, James P. B., Pollard, John R., Saunders, Mark P., Sebag-Montefiore, David, Smitt, Melanie, Staffurth, John, Stratford, Ian J., Wedge, Stephen R.
Published in Nature reviews. Clinical oncology (01.10.2016)
Published in Nature reviews. Clinical oncology (01.10.2016)
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Conference Proceeding
Extended follow-up of a phase 2 trial of xevinapant plus chemoradiotherapy in high-risk locally advanced squamous cell carcinoma of the head and neck: a randomised clinical trial
TAO, Yungan, Sun, Xu-Shan, Pointreau, Yoann, Le Tourneau, Christophe, Sire, Christian, Kaminsky, Marie-Christine, Coutte, Alexandre, Alfonsi, Marc, Calderon, Benôit, Boisselier, Pierre, Martin, Laurent, Miroir, Jessica, Ramee, Jean-Francois, Delord, Jean-Pierre, Clatot, Florian, Rolland, Frederic, Villa, Julie, Magne, Nicolas, Elicin, Olgun, Gherga, Elisabeta, Nguyen, France, Lafond, Cédrik, Bera, Guillaume, Calugaru, Valentin, Geoffrois, Lionnel, Chauffert, Bruno, Damstrup, Lars, Crompton, Philippa, Ennaji, Abdallah, Gollmer, Kathrin, Nauwelaerts, Heidi, Bourhis, Jean
Published in European journal of cancer (1990) (01.04.2023)
Published in European journal of cancer (1990) (01.04.2023)
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Journal Article
Abstract 4183: A novel selective DNA-PK inhibitor, M3814, as a potential combination partner of Etoposide and Cisplatin in the therapy of lung cancer
Sirrenberg, Christian, Zimmermann, Astrid, Grombacher, Thomas, Vassilev, Lyubomir T., Damstrup, Lars, Zenke, Frank T., Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Gene delivery by an epidermal growth factor/DNA polyplex to small cell lung cancer cell lines expressing low levels of epidermal growth factor receptor
Frederiksen, K S, Abrahamsen, N, Cristiano, R J, Damstrup, L, Poulsen, H S
Published in Cancer gene therapy (01.02.2000)
Published in Cancer gene therapy (01.02.2000)
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Journal Article
Double‐blind, placebo‐controlled, randomized study of chlorhexidine prophylaxis for 5‐fluorouracil‐based chemotherapy‐induced oral mucositis with nonblinded randomized comparison to oral cooling (cryotherapy) in gastrointestinal malignancies
Sorensen, Jens Benn, Skovsgaard, Torben, Bork, Ellen, Damstrup, Lars, Ingeberg, Sten
Published in Cancer (01.04.2008)
Published in Cancer (01.04.2008)
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Journal Article
A phase Ia/Ib trial of the DNA-dependent protein kinase inhibitor (DNA-PKi) M3814 in combination with radiotherapy in patients with advanced solid tumors
Van Triest, Baukelien, Damstrup, Lars, Falkenius, Johan, Budach, Volker, Troost, Esther, Samuels, Michael, Goddemeier, Thomas, Geertsen, Poul F.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
Phase II activity of belinostat (PXD-101), carboplatin, and paclitaxel in women with previously treated ovarian cancer
Dizon, Don S, Damstrup, Lars, Finkler, Neil J, Lassen, Ulrik, Celano, Paul, Glasspool, Ros, Crowley, Elizabeth, Lichenstein, Henri S, Knoblach, Poul, Penson, Richard T
Published in International journal of gynecological cancer (01.07.2012)
Published in International journal of gynecological cancer (01.07.2012)
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Journal Article
Abstract 4198: Highly potent and selective DNA-PK inhibitor M3814 with sustainable anti-tumor activity in combination with radiotherapy
Fuchss, Thomas, Mederski, Werner W., Emde, Ulrich, Buchstallter, Hans-Peter, Zenke, Frank, Zimmermann, Astrid, Sirrenberg, Christian, Vassilev, Lubo, Damstrup, Lars, Urbahns, Klaus, Blaukat, Andree
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
A multicenter phase I trial of the DNA-dependent protein kinase (DNA-PK) inhibitor M3814 in patients with solid tumors
van Bussel, Mark, Mau-Soerensen, Morten, Damstrup, Lars, Nielsen, Dorte, Verheul, Henk M.W., Aftimos, Philippe Georges, De Jonge, Maja J., Berghoff, Karin, Schellens, Jan H.M.
Published in Journal of clinical oncology (20.05.2017)
Published in Journal of clinical oncology (20.05.2017)
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Journal Article
암의 치료를 위한 항-PD-L1 항체 및 DNA-PK 억제제의 병용
DAMSTRUP LARS, SCHROEDER ANDREAS, PROKEIN ANNE KATHRIN, ZIMMERMANN ASTRID
Year of Publication 05.12.2019
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Year of Publication 05.12.2019
Patent
단백질 키나제 억제제 및 추가 화학요법제의 조합물
DAMSTRUP LARS, VASSILEV LYUBOMIR, ZIMMERMANN ASTRID, GROMBACHER THOMAS, SIRRENBERG CHRISTIAN
Year of Publication 26.08.2019
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Year of Publication 26.08.2019
Patent
A phase Ia/Ib trial of the DNA-PK inhibitor M3814 in combination with radiotherapy (RT) in patients (pts) with advanced solid tumors: Dose-escalation results
Van Triest, Baukelien, Damstrup, Lars, Falkenius, Johan, Budach, Volker, Troost, Esther, Samuels, Michael, Debus, Juergen, Sørensen, Morten Mau, Berghoff, Karin, Strotman, Rainer, van Bussel, Mark, Goel, Sanjay, Geertsen, Poul F.
Published in JOURNAL OF CLINICAL ONCOLOGY (20.05.2018)
Published in JOURNAL OF CLINICAL ONCOLOGY (20.05.2018)
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Journal Article
Conference Proceeding
589 Xevinapant plus nivolumab in patients with advanced solid tumors who progressed on prior anti–PD-1/PD-L1 treatment: results of a dose-optimization, exploratory phase 1b/2 trial
Emiliano Calvo Aller, Hanna, Glenn, Maria Vieito Villar, Even, Caroline, Moreno, Victor, Kim, Chul, Gulati, Shuchi, Morgensztern, Daniel, Acuna-Villaorduna, Ana, Cassier, Philippe, Jones, Dennie, Bouisset, Florilene, Sahlender, Daniela, Rouits, Elisabeth, Spaggiari, Dany, Damstrup, Lars, Gomez-Roca, Carlos-Alberto
Published in Journal for immunotherapy of cancer (01.11.2022)
Published in Journal for immunotherapy of cancer (01.11.2022)
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Journal Article
Phase II randomized trial of MEK inhibitor pimasertib or placebo combined with gemcitabine in the first-line treatment of metastatic pancreatic cancer
Van Cutsem, Eric, Hidalgo, Manuel, Bazin, Igor, Canon, Jean-Luc, Poddubskaya, Elena, Manojlovic, Nebojsa, Milella, Michele, Radenkovic, Dejan, Verslype, Chris, Guo, Wei, Damstrup, Lars, Hammel, Pascal
Published in Journal of clinical oncology (20.01.2015)
Published in Journal of clinical oncology (20.01.2015)
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Journal Article
P-0014 A Phase II Study With Oxaliplatin, Leucovorin and Tegafur-Uracil as First-Line Treatment for Metastatic or Locally Advanced, Unresectable Esophageal Cancer
Raaschou-Jensen, Nicoline, Oesterlind, Kell, Yilmaz, Mette, Bentzen, Jens, Damstrup, Lars, Baeksgaard, Lene
Published in Annals of oncology (01.06.2012)
Published in Annals of oncology (01.06.2012)
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