Muscle wasting in cancer cachexia: clinical implications, diagnosis, and emerging treatment strategies
Dodson, Shontelle, Baracos, Vickie E, Jatoi, Aminah, Evans, William J, Cella, David, Dalton, James T, Steiner, Mitchell S
Published in Annual review of medicine (18.02.2011)
Published in Annual review of medicine (18.02.2011)
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Effects of enobosarm on muscle wasting and physical function in patients with cancer: a double-blind, randomised controlled phase 2 trial
Dobs, Adrian S, Prof, Boccia, Ralph V, MD, Croot, Christopher C, MD, Gabrail, Nashat Y, MD, Dalton, James T, PhD, Hancock, Michael L, MS, Johnston, Mary A, PharmD, Steiner, Mitchell S, MD
Published in The lancet oncology (01.04.2013)
Published in The lancet oncology (01.04.2013)
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Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials)
Crawford, Jeffrey, Prado, Carla M. M., Johnston, Mary Ann, Gralla, Richard J., Taylor, Ryan P., Hancock, Michael L., Dalton, James T.
Published in Current Oncology Reports (01.06.2016)
Published in Current Oncology Reports (01.06.2016)
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Book Review
Novel Selective Agents for the Degradation of Androgen Receptor Variants to Treat Castration-Resistant Prostate Cancer
Ponnusamy, Suriyan, Coss, Christopher C, Thiyagarajan, Thirumagal, Watts, Kate, Hwang, Dong-Jin, He, Yali, Selth, Luke A, McEwan, Iain J, Duke, Charles B, Pagadala, Jayaprakash, Singh, Geetika, Wake, Robert W, Ledbetter, Christopher, Tilley, Wayne D, Moldoveanu, Tudor, Dalton, James T, Miller, Duane D, Narayanan, Ramesh
Published in Cancer research (Chicago, Ill.) (15.11.2017)
Published in Cancer research (Chicago, Ill.) (15.11.2017)
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TMPRSS2:ERG Gene Fusion Predicts Subsequent Detection of Prostate Cancer in Patients With High-Grade Prostatic Intraepithelial Neoplasia
Park, Kyung, Dalton, James T, Narayanan, Ramesh, Barbieri, Christopher E, Hancock, Michael L, Bostwick, David G, Steiner, Mitchell S, Rubin, Mark A
Published in Journal of clinical oncology (20.01.2014)
Published in Journal of clinical oncology (20.01.2014)
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Selective androgen receptor modulators (SARMs) negatively regulate triple-negative breast cancer growth and epithelial:mesenchymal stem cell signaling
Narayanan, Ramesh, Ahn, Sunjoo, Cheney, Misty D, Yepuru, Muralimohan, Miller, Duane D, Steiner, Mitchell S, Dalton, James T
Published in PloS one (29.07.2014)
Published in PloS one (29.07.2014)
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Estrogen regulates histone deacetylases to prevent cardiac hypertrophy
Pedram, Ali, Razandi, Mahnaz, Narayanan, Ramesh, Dalton, James T, McKinsey, Timothy A, Levin, Ellis R
Published in Molecular biology of the cell (15.12.2013)
Published in Molecular biology of the cell (15.12.2013)
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The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo-controlled phase II trial
Dalton, James T., Barnette, Kester G., Bohl, Casey E., Hancock, Michael L., Rodriguez, Domingo, Dodson, Shontelle T., Morton, Ronald A., Steiner, Mitchell S.
Published in Journal of cachexia, sarcopenia and muscle (01.09.2011)
Published in Journal of cachexia, sarcopenia and muscle (01.09.2011)
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Discovery of 4-Substituted Methoxybenzoyl-aryl-thiazole as Novel Anticancer Agents: Synthesis, Biological Evaluation, and Structure−Activity Relationships
Lu, Yan, Li, Chien-Ming, Wang, Zhao, Ross, Charles R, Chen, Jianjun, Dalton, James T, Li, Wei, Miller, Duane D
Published in Journal of medicinal chemistry (26.03.2009)
Published in Journal of medicinal chemistry (26.03.2009)
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Nonsteroidal Selective Androgen Receptor Modulators (SARMs): Dissociating the Anabolic and Androgenic Activities of the Androgen Receptor for Therapeutic Benefit
Mohler, Michael L, Bohl, Casey E, Jones, Amanda, Coss, Christopher C, Narayanan, Ramesh, He, Yali, Hwang, Dong Jin, Dalton, James T, Miller, Duane D
Published in Journal of medicinal chemistry (25.06.2009)
Published in Journal of medicinal chemistry (25.06.2009)
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FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma
Liu, Qing, Zhao, Xiaobin, Frissora, Frank, Ma, Yihui, Santhanam, Ramasamy, Jarjoura, David, Lehman, Amy, Perrotti, Danilo, Chen, Ching-Shih, Dalton, James T., Muthusamy, Natarajan, Byrd, John C.
Published in Blood (01.01.2008)
Published in Blood (01.01.2008)
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Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia
Phelps, Mitch A., Lin, Thomas S., Johnson, Amy J., Hurh, Eunju, Rozewski, Darlene M., Farley, Katherine L., Wu, Di, Blum, Kristie A., Fischer, Beth, Mitchell, Sarah M., Moran, Mollie E., Brooker-McEldowney, Michelle, Heerema, Nyla A., Jarjoura, David, Schaaf, Larry J., Byrd, John C., Grever, Michael R., Dalton, James T.
Published in Blood (19.03.2009)
Published in Blood (19.03.2009)
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Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design
Bohl, Casey E., Wu, Zengru, Miller, Duane D., Bell, Charles E., Dalton, James T.
Published in The Journal of biological chemistry (04.05.2007)
Published in The Journal of biological chemistry (04.05.2007)
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Structural Basis for Accommodation of Nonsteroidal Ligands in the Androgen Receptor
Bohl, Casey E., Miller, Duane D., Chen, Jiyun, Bell, Charles E., Dalton, James T.
Published in The Journal of biological chemistry (11.11.2005)
Published in The Journal of biological chemistry (11.11.2005)
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MicroRNAs are mediators of androgen action in prostate and muscle
Narayanan, Ramesh, Jiang, Jinmai, Gusev, Yuriy, Jones, Amanda, Kearbey, Jeffrey D, Miller, Duane D, Schmittgen, Thomas D, Dalton, James T
Published in PloS one (27.10.2010)
Published in PloS one (27.10.2010)
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Development of selective androgen receptor modulators (SARMs)
Narayanan, Ramesh, Coss, Christopher C., Dalton, James T.
Published in Molecular and cellular endocrinology (15.04.2018)
Published in Molecular and cellular endocrinology (15.04.2018)
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